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个人简介

Education: Bachelor (B. Eng.) – 2003, Tsinghua University, Beijing, China (Chem. Eng.) Doctor (Dr. Eng.) – 2008, Tsinghua University, Beijing, China (Chem. Eng.) Research Experience: 2016.06-Present Professor, Sch. of Chem. Eng., Tianjin University. 2010.11-2016.06 Associate Professor, Sch. of Chem. Eng., Tianjin University. 2015.01-2016.01 Visiting Scholar, Dept. of Chem. Eng., University of Washington. 2008.08-2010.10 Post doctor, Sch. of Chem. Eng., Tianjin University. 2003.09-2008.07 Ph.D. candidate, Dept. of Chem. Eng., Tsinghua University. 2006.03-2006.09 Visiting researcher, University of California at Riverside, U.S.A. 2002.09-2003.07 Undergraduate, Dept. of Chem. Eng., Tsinghua University. 学术成就: 第三届国家自然科学基金委化学工程青年科学家学术交流研讨会优秀学术报告奖(2013) 天津大学北洋学者-青年骨干教师(2013) 天津大学化工学院青年教讲课比赛第一名(2013) 天津大学第十届青年教师讲课大赛二等奖(2014) 天津大学化工学院第一届“我身边的好老师”荣誉称号(2016) 天津大学教书育人青年先进工作者荣誉称号(2017) 主持科研项目: 1) 新型多酶自组装系统的构建及其催化二氧化碳转化反应的基础研究,国家自然科学基金重点研究计划项目(编号91534119),2016.1-2018.12,80万 2) “智能”溶栓策略探索——多尺度分子动力学模拟,国家自然科学基金青年项目(编号21006069),2011.1-2013.12,20万 3) 病毒样颗粒高效自组装方法研究,天津市自然科学基金重点项目(编号13JCZDJC31100),2013.4-2016.3,20万 4) 疏水电荷诱导色谱过程的分子模拟及其机理解析,中国博士后科学基金面上项目(编号20080440679),2008-2010,3万 5) 蛋白质界面行为,天津大学自主创新基金(北洋青骨),2014.1-2015.12,经费卡110-60301040, 10万 6) 疏水电荷诱导置换色谱的界面过程与分子机理研究,天津大学自主创新基金,2010.1-2011.12,5万 7) 血栓形成过程解析及其抑制多肽设计,天津大学自主创新基金,2011.6-2012.6,5万 8) 蛋白质界面行为的多尺度研究,2011年化工学院优秀青年教师重点培育基金,2011.6-2012.9,10万 专利: 张麟,董晓燕,李艳英,刘晓丹,孙彦,鼠多瘤病毒衣壳粒的新型亲和肽配基及其设计筛选方法,中国发明专利,申请号201410276200X,已授权 张麟,董晓燕,李艳英,刘晓丹,孙彦,鼠多瘤病毒衣壳粒的新型亲和肽配基及其设计筛选方法,PCT,申请号PCT/CN2014/090715 张麟,孙彦,张超,针对血栓形成过程中胶原蛋白-整联蛋白α2β1相互作用的纳米抑制剂及制备方法和应用,中国发明专利,申请号201510176072.6 孙彦,张麟,张超, 胶原蛋白-整联蛋白α2β1相互作用的多肽抑制剂及筛选方法, 中国发明专利,申请号201410151205X

研究领域

蛋白质表界面设计与调控: 以蛋白质表界面行为研究为核心,以蛋白质药物开发及其递送过程的关键问题为导向,综合运用分子模拟和实验研究,建立蛋白质表界面设计与调控方法,系统考察蛋白质、溶剂和表面与蛋白质间的微观相互作用,深入考察病毒样颗粒自组装过程,剖析蛋白质吸附过程,解析血栓形成机理,应用于新型病毒样颗粒疫苗开发,蛋白质色谱界面设计,以及新型血栓抑制剂的仿生设计。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Rational Design of Disulfide Bridges in BbPETaseCD for Enhancing the Enzymatic Performance in PET Degradation Molecules 2023-04-17 | Journal article DOI: 10.3390/molecules28083528 CONTRIBUTORS: Dongjian Huang; Lin Zhang; Yan Sun Development of antithrombotic peptides based on the molecular interactions between von Willebrand factor and GPIbα Chen Ran,Zheng Si,Zhang Lin Page:22670-22678 ISSN:1463-9076 2022 Container-title:Physical Chemistry Chemical Physics Defect engineering of enzyme-embedded metal–organic frameworks for smart cargo release Feng Yi,Cao Xun,Zhang Lin,Li Jingyi,Cui Shitong,Bai Yunxiu,Chen Kequan,Ge Jun Page:135736 ISSN:1385-8947 2022 Container-title:Chemical Engineering Journal Development of the Antithrombotic Peptide LEKNSTY Targeting the Collagen Surface: II. Improvement of Plasma Stability Zheng Si,Ye Zhao,Ji Yufan,Li Nanxing,Zhang Lin Page:7114-7120 ISSN:0743-7463 2022 Container-title:Langmuir Development of the Antithrombotic Peptide LEKNSTY Targeting the Collagen Surface: I. Design and Validation Zheng Si,Hao Tanyi,Zhang Lin Page:7107-7113 ISSN:0743-7463 2022 Container-title:Langmuir Cooperative catalysis by a single-atom enzyme-metal complex Li Xiaoyang,Cao Yufei,Luo Kai,Zhang Lin,Bai Yunxiu,Xiong Jiarong,Zare Richard N.,Ge Jun ISSN:2041-1723 2022 Container-title:Nature Communications N Sun#, Z Ye#, T-Y Hao, S Zheng, Y Sun, Y-C Zhang*, L Zhang*: Inhibition of arterial thrombus formation by blocking exposed collagen surface using LWWNSYY-poly (L-glutamic acid) nanoconjugates. Langmuir, 2021, 37 (22), 6792−6799. L-J Wang, L Zhang*, F-F Liu, Y Sun*: Molecular energetics of doxorubicin pumping by human P-glycoprotein. Journal of Chemical Information and Modeling, 2019, 59, 3889−3898. L Zhang, Y Sun*: Molecular simulation on interfacial behaviors of protein at chromatographic surface. CIESC Journal, 2018, 69 (1): 156–169. Z-Q Jiang, X-Y Dong*, X Yan, Y Liu, L Zhang, Y Sun*: Nanogels of dual inhibitor-modified hyaluronic acid function as a potent inhibitor of amyloid β-protein aggregation and cytotoxicity. Scientific Reports, 2018, 8: 3505. L Zhang, Y Sun*: Molecular simulation on interfacial behaviors of protein at chromatographic surface. CIESC Journal, 2018, 69 (1): 156–169. F-F You, Y Sun, L Zhang*: Design of biomimetic surface for fabrication of monodispersed silver nanoparticles with high catalytic activity. Materials Letters, 2018, 229: 316–319. L Zhang, Y Sun*: Charged Surface Regulates the Molecular Interactions of Electrostatically Repulsive Peptides by Inducing Oriented Alignment. Langmuir, 2018, 34(14): 4390–4397.

学术兼职

Journal of Chromatography A、Langmuir、Chemical Engineering Science、Biochemical Engineering Journal、Applied Catalysis A-General、Journal of Membrane Science、Biosensors and Bioelectronics、Vaccine、化工学报等期刊审稿人,美国化学工程师协会(AIChE)高级会员,Bioresources and Bioprocessing助理编辑。

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