Ziegler, Frederick E. - Yale University

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NIH Career Development Award, 1973-78 NIH Medicinal Chemistry A Study Section, 1979-83 Naito (Japan) Memorial Fellow, 1986 Greater Manchester (UK) Lecturer, 1994

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Ziegler, F. E.; Sarpong, M. A., Radical Cyclization Studies Directed Toward the Synthesis of BMS-200475 "Entecavir": The Carbocyclic Core, Tetrahedron (Symposium-in-Print), 2003, 59, 9013. Ziegler, F. E. ; Kover, R. X.; Yee, N. N. K., Studies Directed Toward the Synthesis of FS-2: Observations on the Fragmentation of Cyclobutylcarbinyl Radicals, Tetrahedron Lett., 2000, 41, 5155. Ziegler, F. E.; Berlin, M. Y.; Lee, K.; Looker, A. R., Formation of 9,10-Unsaturation in the Mitomycins: Facile Fragmentation of b-Alkyl-β-aryl-α-oxo-γ-butyrolactones , Organic Lett., 2000, 2, 3619. Ziegler, F. E.; Wang, Y. Free Radical Studies and Solutions to the Synthesis of (+)-Cyclophellitol, J. Org. Chem., 1998, 63, 7920. Ziegler, F. E.; Berlin, M. Y. A Synthesis of (+)-9a-Desmethoxymitomycin A via Aziridinyl Radical Cyclization, Tetrahedron Lett., 1998, 39, 2455. Ziegler, F. E.; Wang, Y. A Synthesis of (+)-Cyclophellitol from D-Xylose, J. Org. Chem., 1998, 63, 426. Ziegler, F. E.; Belema, M. Aziridinyl Radicals: An Application to the Synthesis of the Core Nucleus of FR-900482, J. Org. Chem., 1997, 62, 1083. Ziegler, F. E.; Wang, Y. Carbon-Carbon Bond Forming Reactions with Oxiranyl Radicals, Tetrahedron Letters, 1996, 37, 6299. Ziegler, F. E.; Petersen, A. K. Tandem Cyclopropylcarbinyl/Oxiranylcarbinyl Radical Rearrangements: An Entry into the Prostaglandin B1 Series, Tetrahedron Letters, 1996, 37, 809. Ziegler, F. E.; Wallace, O. B. The Total Synthesis of (±)-Scopadulcic Acids A and B and ( ±)-Scopadulciol, J. Org. Chem. , 1995, 60, 3626. Ziegler, F. E.; Harran, P. G. A Synthesis of Naturally Occurring (1S,2S,3R)-4-Hydroxymethylcyclopent-4-ene-1,2,3-triol Utilizing the Cyclization of a Dioxolanyl Radical, Syn. Lett., 1995, 493. Ziegler, F. E.; Petersen, A. K. Allyloxy Radicals are Formed Reversibly from Oxiranylcarbinyl Radicals: A Kinetic Study, J. Org. Chem. , 1995, 60, 2666. Ziegler, F. E.; Belema, M. The Cyclization of Chiral Carbon-Centered Aziridinyl Radicals: A New Route to Azirino[2',3':3,4]pyrrolo[1,2-a]indoles , J. Org. Chem., 1994, 59, 7962. Ziegler, F. E.; Petersen, A. K. Tandem Fragmentation of Cyclopropylcarbinyl/Oxiranylcarbinyl Radicals, J. Org. Chem. 1994, 59, 2707. Ziegler, F. E.; Harran, P. G. A Route to Chiral Epoxypyrroloindoles via Oxiranyl Radical Cyclization, Tetrahedron Lett. 1993, 34, 4505. Ziegler, F. E.; Kim, H. A Selective Baeyer-Villiger Oxidation: A Total Synthesis of (-)-Acetomycin, Tetrahedron Lett. 1993, 34, 7669. Ziegler, F. E.; Harran, P. G. A Route to Chiral Epoxypyrroloindoles via Oxiranyl Radical Cyclization, Tetrahedron Lett. 1993, 34, 4505. Ziegler, F. E.; Harran, P. G. Intramolecular Addition of a Dioxolanyl Radical to the Indole Nucleus: Preparation of Enantiomerically Pure, Oxygenated Perhydro-3H-pyrrolo[1,2-a]indoles, J. Org. Chem., 1993, 58, 2768. Ziegler, F. E.; Metcalf III, C. A.; Nangia, A.; Schulte, G.The Structure and Total Synthesis of Sporol and Neosporol, J. Am. Chem. Soc., 1993, 115, 2581. Ziegler, F. E.; Metcalf III, C. A.; Schulte, G. Confirmation by Total Synthesis of the Revised Structure of Sporol: An Application of Cyclic Thionocarbonate-initiated Radical Cyclization, Tetrahedron Lett., 1992, 33, 3117. Ziegler, F. E. Consecutive Rearrangements in Comprehensive Organic Synthesis, vol. 5, pg. 875; ed. B. M. Trost; Pergamon Press, 1991. Ziegler, F. E.; Tung, J. S. Synthetic Studies on the Macrodiolide Elaiophylin, J. Org. Chem., 1991, 56, 6530. Ziegler, F. E.; Jeroncic, L. O. A New Route to 9,9a-3H-Pyrrolo[1,2-a]indoles via Radical Cyclization, J. Org. Chem., 1991, 56, 3479. Ziegler, F. E.; Brown, E. G.; Sobolov, S. B. Single Step Removal of the Allyl Ether Protecting Group with (Ph3P) RhH and Trifluoroacetic Acid, J. Org. Chem., 1990, 55, 3691. Ziegler, F. E.; Becker, M. T. The Total Synthesis of (-)-Denticulatins A and B: Marine Polypropionates from Siphonaria denticulata, J. Org. Chem., 1990, 55, 2800. Ziegler, F. E.; Zheng, Z. The Selective Homolytic Cleavage of Primary Over Secondary Carbon-Oxygen Bonds in Cyclic Thionocarbonates: The Effect of Angle Strain Energy, J. Org. Chem., 1990, 55, 1416. Ziegler, F. E.; Sobolov, S. B. The Synthesis of a Highly Functionalized Carbon Ring Skeleton for the Trichothecene Anguidine, J. Am. Chem. Soc., 1990, 112, 2749. Ziegler, F. E. The 3-Methyl-γ-butyrolactone Route to Polypropionate Natural Products: Strategy and Applications, Proc. 2nd Int. Sym. on Recent Advances in Natural Product Research, Oct. 12-14, 1989 Seoul, Korea; p. 269. Ziegler, F. E.; Cain, W. T. A Formal Synthesis of (-)-Calcimycin (A-23187) via the 3-Methyl-γ-butyrolactone Approach, J. Org. Chem., 1989, 54, 3347. Ziegler, F. E., The Thermal, Aliphatic Claisen Rearrangement, Chem. Rev., 1988, 88, 1423. Ziegler, F. E.; Cain, W. T.; Kneisley, A., Stirchak, E. P.; Wester, R. T., Applications of the 3-Methyl-γ-butyrolactone Strategy to the Synthesis of Polypropionates: The Prelog-Djerassi Lactonic Ester, ent‑Invictolide, and the C19-C27 Fragment of Rifamycin S, J. Am. Chem. Soc., 1988, 110, 5442. Ziegler, F. E.; Kneisley, A.; Thottathil, J. K.; Wester, R. T., 3-Methyl-γ-butyrolactone as a Template for the Synthesis of Polypropionates: The Basic Strategy, J. Am. Chem. Soc., 1988, 110, 5434. Ziegler, F. E.; Jaynes, B. H. Formation of (+)-Forskolin via a Cuprate Addition to a Synthetic Dihydropyran‑4‑one, Tetrahedron Lett., 1988, 29, 2031. Ziegler, F. E.; Nangia, A.; Schulte, G., The Synthesis of Neosporol: A Trichothecene in Search of a Natural Product, Tetrahedron Lett., 1988, 29, 1669. Ziegler, F. E.; Nangia, A.; Tempesta, M. S., Sporol: A Structure Revision, Tetrahedron Lett., 1988, 29, 1665. Ziegler, F. E.; Jaynes, B. H.; Saindane, M. T., A Synthetic Route to Forskolin, J. Am. Chem. Soc. 1987, 109, 8115.

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