个人简介
Selected Published Books ：
Huang Jinhai (chief editor), Principles of Molecular Biology & Practical Application. China Atomic Press.2015.12
Changxin Wu, et.al., 10000 Selected Problems in Sciences—Agriculture Ssciences. China Science Press.2011.
Wang Jiaxin, Qin Aijian, Huang Jinhai, et. al., Immunology, China Agriculture Press.2009.
Diao Enjie, Xu Baocheng, Huang Jinhai. et. al., Food Safety and Quality Management. Chemistry Industry Press.2008.
Li Zhirong, Ding Shuangyang, Huang Jinhai. et. al., Detection Techniques of Veterinary Drug Residues. Tianjin Science and Technology Press.2008.
Shi Zhicheng, Wang Jianhua, Huang Jinhai. et. al., Animal Toxiology, China Agriculture Press.2002.
Research Projects：
“Biosythesis of Key proteins used in veterinary medicine”(TSBICIP-KJGG-014)，supported by Synthetic biotechnology innovation capability improvement project.
R&D of multi-valent avian influenza vaccine based on Saccharomyces cerevisiae chassis”(20YFZCSN00340)., supported by underprop project of Tianjin Science and Technology committee in Tianjin,China.
“Molecular mechanism of multisystem inflammation syndrome caused by staphylococcal enterotoxins”，supported by National Science Fund in China (31272540）
“Study on the virus-like particle vaccine of porcine circovirus type 2 using self-designed S. cerevisiae system”, supported by underprop project of Tianjin Science and Technology committee in Tianjin (16YFZCNC00640)
“ Techniques of cell suspension culture in animal vaccine preparation”, Tianjin science and technology support key project plan(13ZCZDNC08800)
“ Immobiltzation of Recombinant Chitinase with Magnetic Carrier and Analysis on Structure and Effect”(31101362)，supported by National Science Fund in China
“Development of genotyping method and high-output detection kits of staphylococcal enterotoxins in food”(08JCZDJC22600) , supported by a grant from the application basement & advanced technology project of Tianjin Science and Technology committee in Tianjin ,China.
“R&D of a recombinant of porcine antimicrobial Peptide”(07ZCKFNC00600)., supported by underprop project of Tianjin Science and Technology committee in Tianjin,China.
“Study on pathogen variation and control measure of procine productive and respiratory syndrome in Tianjin region ” (08JCZDJC22900), supported by a grant from the application basement & advanced technology project of Tianjin Science and Technology committee in Tianjin ,China.
“Molecular mechanisms of immune response of goats infected with caprine arthritis encephalitis virus”，supported by national Science fund (30771613) in China.
“Research on the protein-chip for diagnosis of some important bovine infectious diseases”, 06YFGZSH02100, supported by Tianjin Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China.
“Study on of the molecular diagnosis kits for diagnosis of caprine arthritis encephalitis virus ”supported by General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China.
“Construction of recombinant plasmid of chicken Marek's disease virus and preparation of major protective antigen protein”, 2013GKF-0482, Beijing academy of agriculture science.
“Rapid detection of Foot and mouth disease virus, avian influenza virus by Helicase-dependent Isothermal DNA Amplification(HAD) techniques”, 2009IK021,Beijing Administration of Quality Supervision, inspection and Quarantine of the People's Republic of China.
“Diagnosis & control key techniques of animal epidemic diseases”, a collaboration plan of foreign expert, supported by Tianjin government.
Honors and Awards：
2012: "Key technologies in modern pig breeding integrated demonstration and promotion", the third prize of Tianjin progress prize in scientific and collective technology by Tianjin government.
2011: “Research & development of a recombinant antibacterial peptide”, the first prize of Dongli District progress prize in scientific and collective technology by Dongli District government of Tianjin.
2012: "Noval estrus suppository used for cattle and goats ", the second Invention prize of Tianjin Binhai district of Tianjin.
2011: “Development of diagnosis kits in genotype identification and high-throughput detection in staphylococcal enterotoxin”, Tianjin scientific and technological achievements in 2011.
2016: “Techniques of cell suspension culture in animal vaccine preparation” , Tianjin scientific and technological achievements in 2016.
2001: “The pathogen isolation and vaccine development of main poultry infectious diseases in Tianjin region”. the second prize of Tianjin progress prize in scientific and collective technology by Tianjin government.
2000："The comprehensive prevention and control technology research——the heterologous cell inactivated vaccine and diagnostic kit for chicken infectious bursal disease"，the first prize of Tianjin progress prize in scientific and collective technology by Shaanxi province government.
2017: "The good supervisor in my mind "(Tenth session), Tianjin University.
2015: The best teacher in 2015 of School of Life Sciences, Tianjin University.
2014: Individual advanced teaching and education award of Tianjin University.
近期论文
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Han Zhang, Zexing Li, Huixia Zhang, Yanyu Guo, Xinyi Zhang, Lilin Zhang, Liu Yang, Shujun Li, Changyan Li, Daqing Cui, Ruyu Xie, Yongqing Li， Jinhai Huang*，Recombinant hemagglutinin displaying on yeast reshapes congenital lymphocyte subsets to prompt optimized systemic immune-protection against avian influenza infection. Front. Microbiol. 2023.115392
Xiaoyang Li, Ruiqi Sun, Yanyu Guo, Huixia Zhang, Ruyu Xie, Xubin Fu, Lei Zhang, Lilin Zhang, Zexing Li*, Jinhai Huang*, N-Acetyltransferase 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Proliferation by N-Terminal Acetylation of the Structural Protein GP5. Microbiology Spectrum, 2023, e02442-22. l Tan Z, Zhai H, Sun R, Sun Z, Xie R, Zhang L, Li Z, Huang J*. Complete genome sequence and phylogenetic analysis of a goose astrovirus isolate in China. Braz J Microbiol. 2023 Mar;54(1):427-434.
Yuanfang Li , Ruiqi Sun , Shujun Li , Zheng Tan , Zexing Li , Yebin Liu,* , Yanyu Guo,* , Jinhai Huang*, ASFV proteins presented at the surface of T7 phages induce strong antibody responses in mice. Journal of Virological Methods,2023, 316:114725.
Ruyu Xie,Huixia Zhang,Han Zhang, Changyan Li,Daqing Cui,Shujun Li, Zexing Li, Hualei Liu*, Jinhai Huang*, Hemagglutinin expressed by yeast reshapes immune microenvironment and gut microbiota to trigger diverse anti-infection response in infected birds. Frontiers in Immunology, 2023. e1125190
Huixia Zhang, Ruyu Xie, Han Zhang, Ruiqi Sun, Shujun Li, Chuandao Xia, Zexing Li, Lilin Zhang,Yanyu Guo*, Jinhai Huang*, Recombinant hemagglutinin protein and DNA-RNA-combined nucleic acid vaccines harbored by yeast elicit protective immunity against H9N2 avian influenza infection. Poultry Science 2023, 102:102662.
Ruiqi Sun, Yanyu Guo, Xiaoyang Li, Ruiqiao Li, Jingxuan Shi, Zheng Tan, Lilin Zhang, Lei Zhang,Jun Han*, Jinhai Huang*，PRRSV Non-Structural Proteins Orchestrate Porcine E3 Ubiquitin Ligase RNF122 to Promote PRRSV Proliferation. Viruses 2022, 14, 424.v14020424.
Hongwei Cao, Deping Hua, Han Zhang, Huixia Zhang, Na Liu, Zhehan Feng, Huliang Li, Baiping Zhao, Lilin Zhang, Yanyu Guo, Jinhai Huang *, Lei Zhang，Oral immunization of recombinant Saccharomyces cerevisiae expressing fiber-2 of fowl adenovirus serotype 4 induces protective immunity against homologous infection. Veterinary Microbiology 271 (2022) 109490.
Lilin Zhang, Lan Yao, Yanyu Guo, Xiaoyang Li, Li Ma, Ruiqi Sun, Xueqing Han, Jing Liu*, Jinhai Huang*, Oral SARS-CoV-2 Spike Protein Recombinant Yeast Candidate Prompts Specific Antibody and Gut Microbiota Reconstruction in Mice. Frontiers in Microbiology |2022, Vol 13. 792532
Linjia Su , Zhe Sun , Fangzheng Qi , Huishan Su , Luomeng Qian, Jing Li , Liang Zuo, Jinhai Huang, Zhilin Yu, Jinping Li, Zhinan Chen, Sihe Zhang*，GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca2+ nanoparticles underlies distinct gene therapy effect in ovarian cancer. J Nanobiotechnology. 2022 Jul 20;20(1):340. doi: 10.1186/s12951-022-01530-6.
Yinna Song1#, Yanyu Guo1#, Xiaoyang Li#, Ruiqi Sun, Min Zhu, Jingxuan Shi,Zhen Tan, Lilin Zhang*, Jinhai Huang*， RBM39 alters phosphorylation of c-Jun and binds to viral RNA to promote PRRSV proliferation. Frontiers in Immunology, 2021.12.1-15.
Zhe Sun#, Jinhai Huang#, Linjia Su, Jing Li, Fangzheng Qi, Huishan Su, Yanan Chen, Qing Zhang, Qiangzhe Zhang, Zongjin Li, Sihe Zhang, Arf6-mediated macropinocytosis-enhanced suicide gene therapy of C16TAB-condensed Tat/ pDNA nanoparticles in ovarian cancer. Nanoscale, 2021.1-14.
Hui Zhai#, Jingxuan Shi#, Ruiqi Sun, Zheng Tan, Umm E Swaiba, Wanqing Li, Lilin Zhang, Lei Zhang，Yanyu Guo*, Jinhai Huang*，The Superposition Anti-viral Activity of Porcine Tri-subtype Interferon Expressed by Saccharomyces cerevisiae. Veterinary microbiology. 2021
Min Zhu#, Xiaoyang Li#, Yinna Song, Peidian Shi, Aiping Cao, Lilin Zhang, yanyu Guo*, Jinhai Huang*, The C/EBPβ-Dependent Induction of TFDP2 Facilitates Porcine Reproductive and Respiratory Syndrome Virus Proliferation. Virologica Sinica, 2021.6,1-11.
Jingxuan Shi #, Heng Chi#, Aiping Cao, Min Zhu, Linlin Zhang, Fuzhou Xu*, Jinhai Huang*，Development of IMBs-qPCR Detection Method for Yersinia enterocolitica Based on the foxA Gene. Archives of Microbiology. 2021, 1-10.
Xiaoyang Li#, Yanyu Guo#, Yinna Song#, Ruiqi Sun, Min Zhu, Zheng Tan, Umm E Swaiba, Lilin Zhang, Jinhai Huang*,The Glycosyltransferase ST3GAL2 Modulate the Proliferation and Inflammation Response in PRRSV Infection，Archives of Virology, 2021,1-10.
Chen Chen#, Deping Hua#, Jingxuan Shi, Zheng Tan, Min Zhu, Kun Tan, Lilin Zhang, Jinhai Huang*，Porcine immunoglobulin Fc fused P30/P54 protein of African swine fever virus displaying on surface of S. cerevisiae elicit strong antibody production in swine. Virologica Sinica, 2021;36 (2):207-219.
Min Zhu, Heng Chi, Xiaoyang Li, Yinna Song, Jingxuan Shi, Jiashun Wang, Jinhai Huang*, The dUTPase of caprine arthritis encephalitis virus negatively regulates interferon signaling pathway, Archives of microbiology, 2021
Aiping Cao, Heng Chi, Jingxuan Shi ,Ruiqi Sun, Kang Du, Yinna Song,Min Zhu, Lilin Zhang, Jinhai Huang* Visual detection of Clostridium perfringens alpha toxin by combining nanometer microspheres with smart phones. Microorganisms 2020,8 (12),1865.
Jiaqi Wu#, HengChi#, Yanyu Guo, Aiping Cao, Jingxuan Shi, Min Zhu, Lilin Zhang, DepingHua*, Jinhai Huang*, Antiviral Protein Viperin Modulate N protein to Inhibit Porcine Epidemic Diarrhea Virus proliferation. Archives of Virology, 2020, 165:2279–2289
Peidian Shi, Yanyu Guo, Yanxin Su, Min Zhu, Yali Fu, Heng Chi, Jiaqi Wu, Jinhai Huang*，SUMOylation of DDX39A alters binding & export of antiviral transcripts to control innate immunity. Journal of Immunology, 2020, 205(1):168-180.
Yanyu Guo, Ruiqiao Li, Zheng Tan, Jingxuan Shi, Yali Fu, Yinna Song, Min Zhu, Lei Zhang, Jinhai Huang*，E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis. Molecular Immunology. 2020, 121, 195-203.
Yali Fu, Dong Lu,· Yanxin Su,, Heng Chi, Jiashun Wang, Jinhai Huang*，Vif Protein of Caprine Arthritis Encephalitis Virus Inhibits Interferon Production, Archives of Virology. 2020, 1-11.
Xiao Xiao,Wentao Zhang, Deping Hua, Lilin Zhang, Wei Meng, Jinhai Huang*, Lei Zhang*, Cold-inducible RNA-binding protein (CIRBP) promotes porcine reproductive and respiratory syndrome virus (PRRSV)-induced inflammatory response. International Immunopharmacology. 2020, 86:106728.
Ruiqiao Li#, Chen Chen#, Jing He, Lilin Zhang, Lei Zhang, Yanyu Guo, Jinhai Huang*, E3 Ligase ASB8 Promotes PRRSV Proliferation and Function via Stabilizing of Nsp 1α and Degrading of IKK. Virology, 2019，532：55–68.
Xiao Xiao,Wentao Zhang, Deping Hua, Lilin Zhang, Wei Meng, Jinhai Huang*, Lei Zhang*, Cold-inducible RNA-binding protein (CIRBP) promotes porcine reproductive and respiratory syndrome virus (PRRSV)-induced inflammatory response. International Immunopharmacology. 2020, 86:106728.
Chengxue Zhao#, Chen Chen#, Ying Li, Shuren Dong, Kun Tan,,Yuhui Tian,,Lilin Zhang, Jinhai Huang*, Lei Zhang*, Genomic characterization of a novel recombinant porcine astrovirus isolated in northeastern China. Archives of Virology, 2019, 164(3): 1469-1473.
Peidian shi#; Yanxin Su#; Yi Li#; Lilin Zhang; Dong Lu; Ruiqiao Li; Lei Zhang; Jinhai Huang*，The alternatively spliced porcine FcγRI regulated PRRSV-ADE infection and proinflammatory cytokine production. Developmental and Comparative Immunology, 2019, 90: 186~196.
Peidian Shi1#, Yanxin Su1#, Ruiqiao Li1, Zhixuan Liang, Shuren Dong, Jinhai Huang*，PEDV nsp16 negatively regulates innate immunity to promote viral proliferation. Virus Research, 2019, 265，57–66.
Yanxin Su(#); Peidian Shi(#); Lilin Zhang; Dong Lu; Chengxue Zhao; Ruiqiao Li; Lei Zhang*; Jinhai Huang*,The Superimposed Deubiquitination Effect of OTULIN and PRRSV Nsp11 Promoted the Multiplication of PRRSV. Journal of Virology, 2018.2.12, 92(9): 1-17.
Peidian Shi(#); Yanxin Su(#); Ruiqiao Li; Lei Zhang; Chen Chen; Lilin Zhang; Kay Faaberg*; Jinhai Huang*, Dual Regulation of Host TRAIP Post-translation and Nuclear/Plasma Distribution by Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 1a Promotes Viral Proliferation. Frontiers in Immunology, 2018.12.6, 9(3023): 1~18.
Peidian Shi(#); Lilin Zhang(#); Jiashun Wang(#); Dong Lu; Yi Li; Jie Ren; Menglu Shen; Lei Zhang; Jinhai Huang*, Porcine FceRI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction. Virologica Sinica (2018) 33:249–260.
Chen Pei(#); Zhang Lei(#); Chang Na; Shi Peidian; Gao Tian; Zhang Lilin*, Huang Jinhai*, Preparation of virus-like particles for porcine circovirus type 2 by YeastFab Assembly. Virus Genes, 2018.4, 54(2): 246~255.
Lei Zhang#; Jie Ren#; Peidian Shi; Dong Lu; Chengxue Zhao; Yanxin Su; Lilin Zhang; Jinhai Huang*, The Immunological Regulation Roles of Porcine b-1, 4 Galactosyltransferase V (B4GALT5) in PRRSV Infection. Frontiers in Cellular and Infection Microbiology, 2018.2.9, 8(48): 1~13.
Ruiqiao Li, Xuefeng Qi,Xueying Han,Caihong Liu, Jing Wang, Ruichun Wang, Jingyu Wang*, Jinhai Huang*,Deterioration of eggshell quality is related to calbindin in laying hens infected with velogenic genotype VIId Newcastle disease virus. Theriogenology.2017,91(3):62-68. IF: 2.288, Q1, 26/142.
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