个人简介
Education Background：
Ph.D. | Tianjin University | Biochemical Engineering | 2003
Master | Tianjin Medical University | Endocrinology | 1999
Bachelor | Tianjin Medical University | Pharmaceutical | 1994
Positions & Employments：
2006.1-Now Tianjin University
学术成就:
高等教育国家级教学成果奖二等奖，2009
中国科技论文在线优秀评审专家，2010
中国药学会科学技术奖一等奖，2017
北京市科学技术进步奖二等奖，2020
第一发明人授权专利：
ZL201210465441.X 针对乏氧诱导因子-1a的纳米抗体及其编码序列
ZL201310293868.0 一种萤火虫荧光素酶及其编码基因及获取方法
ZL201310318276.X 靶向性重组PF4及其表达系统
ZL201520121594.1 乳腺癌早期预报家庭三联卡胶体金试剂盒
ZL201510665921.4 一种突变型Sus scrofa猪源胰蛋白酶及其编码基因及获取方法和应用
ZL201510176123.5 靶向性重组PF4及其表达系统
研究领域
药物合成生物学：
1. 合成生物肠道菌（群）体系构建及应用
2. 纳米抗体等功能生物大分子的理性设计及高效制备
3. 肠道微生态平衡与人体健康
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Single-cell microfluidics enabled dynamic evaluation of drug combinations on antibiotic resistance bacteria
Talanta
2023-12 | Journal article
DOI: 10.1016/j.talanta.2023.124814
CONTRIBUTORS: Xiaobo Li; Yanqing Song; Xiuzhao Chen; Jianan Yin; Ping Wang; He Huang; Huabing Yin
Breaking through the therapeutic ceiling of inflammatory bowel disease: Dual-targeted therapies
Biomedicine & Pharmacotherapy
2023-02 | Journal article
DOI: 10.1016/j.biopha.2022.114174
CONTRIBUTORS: Zelin Feng; Guangbo Kang; Jiewen Wang; Xingjie Gao; Xiaoli Wang; Yulin Ye; Limin Liu; Jingwen Zhao; Xinjuan Liu; He Huang et al.
Positive Interventional Effect of Engineered Butyrate-Producing Bacteria on Metabolic Disorders and Intestinal Flora Disruption in Obese Mice
Microbiology Spectrum
2022-04-27 | Journal article
DOI: 10.1128/spectrum.01147-21
CONTRIBUTORS: Lina Wang; Xiaoming Cheng; Liang Bai; Mengxue Gao; Guangbo Kang; Xiaocang Cao; He Huang; Cheng-Yuan Kao
Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development
Acta Pharmaceutica Sinica B
2021 | Journal article
DOI: 10.1016/j.apsb.2021.03.004
EID: 2-s2.0-85108117359
Part of ISSN: 22113843 22113835
CONTRIBUTORS: Wang, Y.; Zhang, X.; Wang, Y.; Zhao, W.; Li, H.; Zhang, L.; Li, X.; Zhang, T.; Zhang, H.; Huang, H. et al.
VHH212 nanobody targeting the hypoxia-inducible factor 1α suppresses angiogenesis and potentiates gemcitabine therapy in pancreatic cancer in vivo
Cancer Biology and Medicine
2021 | Journal article
DOI: 10.20892/j.issn.2095-3941.2020.0568
Part of ISSN: 2095-3941
Current Status of Mining, Modification, and Application of Cellulases in Bioactive Substance Extraction
Current Issues in Molecular Biology
2021-07 | Journal article | Author
DOI: 10.3390/cimb43020050
CONTRIBUTORS: Yawei Hu; Guangbo Kang; Lina Wang; Mengxue Gao; Ping Wang; Dong Yang; He Huang
A Potential Combination Therapy of Berberine Hydrochloride With Antibiotics Against Multidrug-Resistant Acinetobacter baumannii
Frontiers in Cellular and Infection Microbiology
2021-03-25 | Journal article
DOI: 10.3389/fcimb.2021.660431
Part of ISSN: 2235-2988
Effect of Humanizing Mutations on the Stability of the Llama Single-Domain Variable Region
Biomolecules
2021-01-26 | Journal article
DOI: 10.3390/biom11020163
Part of ISSN: 2218-273X
A Smoothing Newton Method with a Mixed Line Search for Monotone Weighted Complementarity Problems
Mathematical Problems in Engineering
2020 | Journal article
DOI: 10.1155/2020/7986351
EID: 2-s2.0-85088702916
Part of ISSN: 15635147 1024123X
CONTRIBUTORS: Jiang, X.; Huang, H.
A sound strategy for homology modeling-based affinity maturation of a HIF-1α single-domain intrabody
bioRxiv
2020 | Other
DOI: 10.1101/2020.05.14.096149
EID: 2-s2.0-85098898379
Part of ISSN: 26928205
CONTRIBUTORS: Hu, M.; Kang, G.; Cheng, X.; Wang, J.; Li, R.; Bai, Z.; Yang, D.; Huang, H.
Attach importance to research and development of Chinese materia medica based on prevention and control needs of SARS-CoV-2 infection,基于新型冠状病毒感染防控需求，重视中药科学研发与应用
Chinese Traditional and Herbal Drugs
2020 | Journal article
DOI: 10.7501/j.issn.0253-2670.2020.06.001
EID: 2-s2.0-85084855035
Part of ISSN: 02532670
CONTRIBUTORS: Liu, C.-X.; Wang, Y.-L.; Zhang, H.-B.; Tian, C.-W.; Huang, H.; Zhang, T.-J.
Engineered butyrate-producing bacteria prevents high fat diet-induced obesity in mice
Microbial Cell Factories
2020-12 | Journal article
DOI: 10.1186/s12934-020-01350-z
Part of ISSN: 1475-2859
In vitro affinity maturation to improve the efficacy of a hypoxia-inducible factor 1α single-domain intrabody
Biochemical and Biophysical Research Communications
2020-09 | Journal article
DOI: 10.1016/j.bbrc.2020.06.097
Part of ISSN: 0006-291X
Comparative genomics analysis of Acinetobacter haemolyticus isolates from sputum samples of respiratory patients
Genomics
2020-07 | Journal article
DOI: 10.1016/j.ygeno.2020.03.016
Part of ISSN: 0888-7543
学术兼职
国家现代中药创新中心技术专委会副主委
中国抗癌协会肿瘤精准治疗专委会委员
中国生物物理学会肠道菌群分会委员
热心肠智库专家
国家自然科学基金及部分省市自然科学基金评审专家
Frontiers工程益生菌专刊客座主编，Elsevier、Wiley旗下部分期刊审稿人
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