Yan, Elsa - Yale University - Department of Chemistry

个人简介

Sir Edward Youde Memorial Scholarship, Hong Kong, 1994 First Class Honors for B.Sci., Chinese University of Hong Kong, Hong Kong, 1995 Distinction for Ph.D., Columbia University, New York, 2000 Pegram Award for graduate research, Columbia University, New York, 2000 Petroleum Research Fund Award, American Chemical Society, 2009-2011 Starter Grant Award, Spectroscopy Society of Pittsburgh, 2009-2010 NSF CAREER Award, National Science Foundation, 2010-2015 Tour speaker, Society of Applied Spectroscopy, 2011 The Greer Memorial Prize for Achievement in Research in Nature Sciences, Yale University, 2011 Early Excellent in Physical Organic Chemistry, Journal of Physical Organic Chemistry, 2012 Elected Vice Chair, Gordon Research Conference: Vibrational Spectroscopy, 2014 Elected Chair, Gordon Research Conference: Vibrational Spectroscopy, 2016

研究领域

Biophysical Chemistry/Physical Chemistry/Chemical Biology

近期论文

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Liu, Y.†; Cai, Y.†; Liu, W.; Li, X. H.; Rhoades, E.; Yan, E. C. Y.*"Triblock Peptide-Linker-Lipid Molecular Design Improves Potency of Peptide Ligands Targeting Family B G Protein-Coupled Receptors" Chem. Comm. 2015. Yan, E. C. Y.*; Wang, Z.; Fu, L. "Proteins at Interfaces Probed by Chiral Sum Frequency Generation Spectroscopy" J. Phys. Chem. B 119, 2769, 2015. Guo, Y.; Skharan, S.; Liu, J.; Batista, V. S.; Tully, J. C.*; Yan, E. C. Y.* "Role of Unusual Temperature-Dependent Kinetics of Thermal Reactions of Rhodopsin in Vertebrate Dim-Light Vision" Proc. Natl. Acad. Sci. U.S.A. 108, 26111, 2014. Mooney, V.; Skharan, S.; Liu, J.; Guo, Y.; Batista, V. S.; Yan, E. C. Y.* "Kinetics of Thermal Activation of an Ultraviolet Cone Pigment" J. Am. Chem. Soc. 137, 307, 2014. Fu, L.; Wang, Z.; Yan, E. C. Y.* "N-H Stretching Modes Around 3300 Wavenumber From Peptide Backbones Observed by Chiral Sum Frequency Generation Vibrational Spectroscopy" Chirality 22, 306, 2014. Yan, E. C. Y.*; Fu, L.; Wang, Z.; Liu, W. "Biological Macromolecules at Interfaces Probed by Chiral Sum Frequency Generation Spectroscopy" Special Thematic Issue: Aqueous Interfaces, Chem. Rev. 114, 8471, 2014. Sekharan, S.*; Mooney, V.; Rivalta, I.; Kazmi, M. A.; Neitz, M.; Neitz, J.; Sakmar, T. P.; Yan, E. C. Y.*, Batista, V. B.* "Spectral Tuning of Ultraviolet Cone Pigments: An Interhelical Lock Mechanism" J. Am. Chem. Soc. 135, 19064, 2013. Liu, W.; Wang, Z.; Fu, L.; Leblanc, R. M.; Yan, E. C. Y.* "Lipid Compositions Modulate Fluidity and Stability of Bilayers: Characterization by Surface Pressure and Sum Frequency Generation Spectroscopy" Langmuir 29,15022, 2013. Guo, Y.; Young, K.; Yan, E. C. Y.* Book Chapter: "Guided Inquiry and Project-Based Learning in Biophysical Spectroscopy" in Teaching Bioanalytical Chemistry , Edited by Harvey J. M. Hou, ACS Books, Chapter 13, p261-291, 2013. Liu, M. Y.#; Liu, J.; Mehrotra, D.#; Liu, Y.; Guo, Y.; Baldera-Aguayo, P. A.; Mooney, V.; Nour, A. M.; Yan, E. C. Y.* "Thermal Stability of Rhodopsin and Progression of Retinitis Pigmentosa: A Comparison of S186W and D190N Rhodopsin Mutants" J. Biol. Chem. 288, 17698, 2013. Wang, Z.; Fu, L.; Yan, E. C. Y.* "C–H Stretch for Probing Kinetics of Self-Assembly into Macromolecular Chiral Structures at Interfaces by Chiral Sum Frequency Generation Spectroscopy" Langmuir 29, 4077, 2013. Fu, L.†; Xiao, D. Q.†; Wang, Z.; Batista, V. S.*; Yan, E. C. Y.* "Chiral Sum Frequency Generation for In Situ Probing Proton Exchange in Antiparallel β-Sheets at Interfaces" J. Am. Chem. Soc. 135, 3592, 2013. Mitra, N.†; Liu, Y.†; Liu, J.; Serebryany, E.; Mooney, V.; DeVree, B. T.; Sunahara, R. K.; Yan, E. C. Y.* "Calcium-Dependent Ligand Binding and G-protein Signaling of Family B GPCR Parathyroid Hormone 1 Receptor Purified in Nanodiscs" ACS Chem. Biol. 8, 617, 2013. Zhu, G. A.#; Serebryany, E.#; Yan, E. C. Y.* "Rational Design of Supramolecular Lipid/Detergent Assemblies for Purification of G Protein-Coupled Receptors" Invited Submission, Encyclopedia of Supramolecular Chemistry, 2012. Mooney, V.; Szundi, I.; Lewis, J. W.; Yan, E. C. Y.*; Kliger, D. S.* "Schiff Base Protonation Changes in Siberian Hamster Ultraviolet Cone Pigment Photointermediates" Biochemistry 51, 2630, 2012. You, Y. M.†; Bloomfield, A.†; Liu, J.; Fu, L.; Herzon, S.*; Yan, E. C. Y.* "Real-Time Kinetics of Surfactant Molecules Transfer between Emulsion Particles Probed by In Situ Second Harmonic Generation Spectroscopy" J. Am. Chem. Soc. 134, 4264, 2012. Xiao, D. Q.†; Fu, L.†; Liu, J.; Batista, V. S.*; Yan, E. C. Y.* "Amphiphilic Adsorption of Human Islet Amyloid Polypeptide Aggregates to Lipid/Aqueous Interfaces" J. Mol. Biol. 421, 537, 2012. Serebryany, E.#; Zhu, G. A.#; Yan, E. C. Y.* "Artificial membrane-like environments for in vitro studies of purified G-protein coupled receptors" Invited Review, BBA-Biomembrane 1818, 225, 2012. Fu, L.; Wang, Z.; Yan, E. C. Y.* "Chiral Vibrational Structures of Proteins at Interfaces Probed by Sum Frequency Generation Spectroscopy" Invited Submission, Special Issue: Applications of Circular Dichroism, Int. J. Mol. Sci. 12, 9404, 2011. Liu, J; Liu, M. Y.#; Fu, L.; Zhu, G. A.#; Yan, E. C. Y.* "Chemical Kinetic Analysis of Thermal Decay of Rhodopsin Reveals Unusual Energetics of Thermal Isomerization and Hydrolysis of Schiff Base" J. Biol. Chem. 286, 38408, 2011.