程景胜 - 天津大学

个人简介

程景胜，男，博士，副教授，硕士生导师，教育部新世纪优秀人才计划获得者。天津市细胞生物学会理事。1995年西南大学获学士学位，2002年天津师范大学获硕士学位，2006年毕业于天津大学获博士学位，从事细胞培养和细胞信号转导的研究。2006年至今，天津大学工作，主要研究方向是系统生物技术与生物制药工程。2010年在美国麻省理工学院生物信息学与代谢工程实验室做访问学者。科研项目: (1) 主持国家自然科学基金 5项； (2) 主持国家重点研发计划项目课题 1项； (3) 主持973计划子课题 2 项； (4) 主持教育部新世纪优秀人才支持计划 1项； (5) 主持天津市自然科学基金（重点项目）1项； (6) 主持科技部农业科技成果转化项目 1项。学术成就: 2011年，教育部新世纪优秀人才计划获得者； 2009年，获国家留学基金委资助，作为天津大学青年骨干教师（访问学者）2010.9-2011.10年在美国麻省理工学院化工系 Gregory Stephanopoulos 院士Bioinformatics & Metabolic Engineering实验室进行交流访问一年；研究工作集中于微生物制药，针对"微生物细胞对环境的适应性及产物合成的高效性”问题，①运用系统生物学方法从蛋白和代谢物水平揭示工业酵母菌接种密度的依赖性和真空环境适应性响应机制，发现高密度接种导致细胞代谢途径间转换的特性；②采用工程策略调节多粘芽孢杆菌胞外氧化还原态势，结合外源还原剂调节显著提高2,3-丁二醇产量和产率。③建立了提高次生代谢物产量的新策略，为新型抗生素合成调节提供理论依据；有助于运用合成生物学和系统代谢工程策略构建robust的工业菌株。④研究辅因子对SMX降解和生物转化的影响, 探究SMX在微生物细胞内的代谢途径，为人工建立以辅因子为基础的混菌体系提供依据。已发表学术论文60余篇，获得授权专利9项，申请专利10项。

研究领域

1. 生物制药: 抗菌活性物; 生物表面活性剂; 绿色生物农药 2. 抗生素生物转化 3. 合成生物学：人工混菌系统

近期论文

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Enhancing fengycin production in the co-culture of Bacillus subtilis and Corynebacterium glutamicum by engineering proline transporter Geng-Rong Gao , Si-Yu Wei , Ming-Zhu Ding , Zheng-Jie Hou, Dun-Ju Wang , Qiu-Man Xu , Jing-Sheng Cheng , Ying-Jin Yuan https://doi.org/10.1016/j.biortech.2023.129229 Fermentation optimization of surfactin production of Bacillus amyloliquefaciens HM618 Song Liu, Min-Hui Tang, Jing-Sheng Cheng First published: 24 February 2022 https://doi.org/10.1002/bab.2327 Mutualistic microbial community of Bacillus amyloliquefaciens and recombinant Yarrowia lipolytica co-produced lipopeptides and fatty acids from food waste Bai Song,Qiao Bin,Hou Zheng-Jie,Gao Geng-Rong,Cao Chun-Yang,Cheng Jing-Sheng,Yuan Ying-Jin Page:136864 ISSN:0045-6535 Improved Production of Fengycin in Bacillus subtilis by Integrated Strain Engineering Strategy Geng-Rong Gao, Zheng-Jie Hou, Ming-Zhu Ding, Song Bai, Si-Yu Wei, Bin Qiao, Qiu-Man Xu*, Jing-Sheng Cheng*, and Ying-Jin Yuan Cite this: ACS Synth. Biol. 2022, 11, 12, 4065–4076 Publication Date:November 15, 2022 https://doi.org/10.1021/acssynbio.2c00380 Construction of multi-strain microbial consortia producing amylase, serine and proline for enhanced bioconversion of food waste into lipopeptides Sun Hui-Zhong,Chen Xin-Yue,Zhang Yu-Miao,Qiao Bin,Xu Qiu-Man,Cheng Jing-Sheng,Yuan Ying-Jin Page:108682 ISSN:1369-703X Artificial microbial consortium producing oxidases enhanced the biotransformation efficiencies of multi-antibiotics Xu Shu-Jing,Chen Xin-Yue,Wang Xiao-Feng,Sun Hui-Zhong,Hou Zheng-Jie,Cheng Jing-Sheng,Yuan Ying-Jin Page:129674 ISSN:0304-3894 Xin-Yue Chen, Hui-Zhong Sun, Bin Qiao, Chang-Hao Miao, Zheng-Jie Hou, Shu-Jing Xu, Qiu-Man Xu, Jing-Sheng Cheng. Improved the lipopeptide production of Bacillus amyloliquefaciens HM618 under co-culture with the recombinant Corynebacterium glutamicum producing high-level proline. Bioresource Technology，2022, 349：126863. Chang-Hao Miao, Xiao-Feng Wang, Bin Qiao, Qiu-Man Xu, Chun-Yang Cao, Jing-Sheng Cheng*. Artificial consortia of Bacillus amyloliquefaciens HM618 and Bacillus subtilis for utilizing food waste to synthetize iturin A. Environmental Science and Pollution Research, 2022, doi: 10.1007/s11356-022-21029-9 Xiao-Feng Wang, Chang-Hao Miao, Bin Qiao, Shu-Jing Xu, Jing-Sheng Cheng*. Co-culture of Bacillus amyloliquefaciens and recombinant Pichia pastoris for utilizing kitchen waste to produce fengycins. Journal of Bioscience and Bioengineering, 2022, 133(6):560-566. Li-Hua Yang, Bin Qiao, Qiu-Man Xu*, Song Liu, Ye Yuan, Jing-Sheng Cheng*. Biodegradation of sulfonamide antibiotics through the heterologous expression of laccases from bacteria and investigation of their potential degradation pathways. Journal of Hazardous Materials, 2021, 416:125815. Fu-Di Pan, Song Liu, Qiu-Man Xu*, Xin-Yue Chen, Jing-Sheng Cheng*. Bioconversion of kitchen waste to surfactin via simultaneous enzymolysis and fermentation using mixed-culture of enzyme- producing fungi and Bacillus amyloliquefaciens HM618. Biochemical Engineering Journal, 2021,172:108036. Wei Shang, Bin Qiao, Qiu-Man Xu*, Jing-Sheng Cheng*. Potential biotransformation pathways and efficiencies of ciprofloxacin and norfloxacin by an activated sludge consortium. Science of the Total Environment, 2021, 785:147379. Ye Yuan, Qiu-Man Xu*, Si-Cen Yu, Hui-Zhong Sun, Jing-Sheng Cheng*, Ying-Jin Yuan. Control of the polymyxin analog ratio by domain swapping in the nonribosomal peptide synthetase of Paenibacillus polymyxa. Journal of Industrial Microbiology & Biotechnology, 2020, 47(6-7):551-562. Chun-Xiao Liu, Qiu-Man Xu, Si-Cen Yu, Jing-Sheng Cheng, Ying-Jin Yuan. Bio-removal of tetracycline antibiotics under the consortium with probiotics Bacillus clausii T and Bacillus amyloliquefaciens producing biosurfactants. Science of the Total Environment, 2020, 710: 136329. Xiu-Xiu Kong, Jian-Lan Jiang, Bin Qiao, Hong Liu,Jing-Sheng Cheng*, Ying-Jin Yuan. The biodegradation of cefuroxime, cefotaxime and cefpirome by the synthetic consortium with probioticBacillus clausiiand investigation of their potential biodegradation pathways. Science of The Total Environment, 2019, 651( 1): 271-280.

学术兼职

1）担任国家自然科学基金；美国自然科学基金会（NSF）；新加坡（MOE Translational R&D and Innovation Fund），广西自然科学基金，黑龙江省自然科学基金等通讯评审专家； 2）担任国际刊物审稿人: Frontiers in Microbiology, Bioresource Technology，Journal of Chemical Technology & Biotechnology, International Journal of Biomedical Science, Proteomics Insights, Biotechnology and Applied Biochemistry, Frontiers of Chemical Engineering in China等的审稿人； 3）天津市细胞生物学会理事。