陈涛 - 天津大学 - 化工学院

个人简介

Dr. Chen received his PhD degree from School of Chemical Engineering & Technology, Tianjin University in 2004, then worked as a postdoctoral fellow at Tianjin University from 2004 to 2006. He joined Tianjin University as an associate professor in 2007 and his research interests focus on the area of metabolic engineering and synthetic biology, mainly including: (i) Genome scale metabolic network construction and in silicon analysis for pathway optimization. (ii) Metabolic engineering of microbe for production of platform chemicals. (iii)The development of genome editing tools and genome reduced bacteria. He has published more than 70 SCI papers (ResearcherID: N-1817-2015; ORCID ID: 0000-0001-9588-1821) which have been cited more than 1300 times in web of science and nearly 2000 times in google scholar (H-index of 20 in web of science and 25 in google scholar). He also has co-authored three books since 2008, and got 8 projects supported by the government and two projects supported by companies. Education Background Doctoral Degree | Tianjin University | Biochemical Engineering | 2006 Master Degree | Tianjin University of Science &Technology | Fermentation Engineering | 2000 Bachelor Degree | Hubei University of Technology | Fermentation Engineering | 1996 Positions & Employments 2007.1- Tianjin University | Associate Professor 2004.9-2006.12 Tianjin University | Post Doctorate

研究领域

主要研究方向为生物反应工程、代谢工程和合成生物学，主要采用代谢工程方法系统优化微生物细胞性能，或采用合成生物技术构建优良微生物底盘细胞与基因元件，实现生物合成途径的优化，重点致力于开发重要生物基化学品、药物及天然产物的生物反应与加工过程。

近期论文

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Riboswitches, from cognition to transformation June 2023 Synthetic and Systems Biotechnology 8(3) DOI:10.1016/j.synbio.2023.05.008 Jingdong Xu, Junyuan Hou, Mengnan Ding, Zhiwen Wang, Tao Chen Efficient production of acetoin from lactate by engineered Escherichia coli whole-cell biocatalyst May 2023 Applied Microbiology and Biotechnology 107(8):1-14 DOI:10.1007/s00253-023-12560-x Zhen Cui, Meiyu Zheng, Mengnan Ding, Wei Dai, Zhiwen Wang, Tao Chen Unveiling the Effect of NCgl0580 Gene Deletion on 5-Aminolevulinic Acid Biosynthesis in Corynebacterium glutamicum February 2023 Fermentation 9(3):213 DOI:10.3390/fermentation9030213 Jian Wu, Meiru Jiang, Shutian Kong, Kunqiang Hong, Juntao Zhao, Xi Sun, Zhen Cui, Tao Chen, Zhiwen Wang Production of 3-Hydroxypropionic Acid from Renewable Substrates by Metabolically Engineered Microorganisms: A Review February 2023 Molecules 28(4):1888 DOI:10.3390/molecules28041888 Xiaodi Wang, Zhen Cui, Xi Sun, Zhiwen Wang, Tao Chen Biosynthesis of Nicotinamide Mononucleotide: Current Metabolic Engineering Strategies, Challenges, and Prospects Fermentation 2023-06 | Journal article | Author DOI: 10.3390/fermentation9070594 CONTRIBUTORS: Shiqi Luo; Juntao Zhao; Yangyang Zheng; Tao Chen; Zhiwen Wang Microbial Synthesis of Heme b: Biosynthetic Pathways, Current Strategies, Detection, and Future Prospects Molecules 2023-04 | Journal article | Author DOI: 10.3390/molecules28083633 CONTRIBUTORS: Qiuyu Yang; Juntao Zhao; Yangyang Zheng; Tao Chen; Zhiwen Wang Adaptive Laboratory Evolution of Halomonas bluephagenesis Enhances Acetate Tolerance and Utilization to Produce Poly(3-hydroxybutyrate) Molecules 2022-05 | Journal article | Author DOI: 10.3390/molecules27093022 CONTRIBUTORS: Jing Zhang; Biao Jin; Jing Fu; Zhiwen Wang; Tao Chen Advances in the Extraction, Purification and Detection of the Natural Product 1-Deoxynojirimycin Critical Reviews in Analytical Chemistry 2020 | Journal article DOI: 10.1080/10408347.2019.1711012 EID: 2-s2.0-85077850757 Part of ISBN: 15476510 10408347 CONTRIBUTORS: Hong, K.-Q.; Fu, X.-M.; Yin, H.; Li, S.-T.; Chen, T.; Wang, Z.-W. Development of Novel Bioreactor Control Systems Based on Smart Sensors and Actuators Frontiers in Bioengineering and Biotechnology 2020 | Journal article DOI: 10.3389/fbioe.2020.00007 EID: 2-s2.0-85079660080 Part of ISBN: 22964185 CONTRIBUTORS: Wang, B.; Wang, Z.; Chen, T.; Zhao, X. Engineering central pathways for industrial-level (3R)-acetoin biosynthesis in Corynebacterium glutamicum Microbial cell factories 2020 | Journal article DOI: 10.1186/s12934-020-01363-8 EID: 2-s2.0-85084625407 Part of ISBN: 14752859 CONTRIBUTORS: Lu, L.; Mao, Y.; Kou, M.; Cui, Z.; Jin, B.; Chang, Z.; Wang, Z.; Ma, H.; Chen, T. Engineering corynebacterium glutamicum for the efficient production of 3-hydroxypropionic acid from a mixture of glucose and acetate via the malonyl-coA pathway Catalysts 2020 | Journal article DOI: 10.3390/catal10020203 EID: 2-s2.0-85079454072 Part of ISBN: 20734344 CONTRIBUTORS: Chang, Z.; Dai, W.; Mao, Y.; Cui, Z.; Wang, Z.; Chen, T. Production of riboflavin and related cofactors by biotechnological processes Microbial Cell Factories 2020 | Journal article DOI: 10.1186/s12934-020-01302-7 EID: 2-s2.0-85079338110 Part of ISBN: 14752859 CONTRIBUTORS: Liu, S.; Hu, W.; Wang, Z.; Chen, T. Substrate profiling and tolerance testing of Halomonas TD01 suggest its potential application in sustainable manufacturing of chemicals Journal of Biotechnology 2020 | Journal article DOI: 10.1016/j.jbiotec.2020.04.007 EID: 2-s2.0-85083554819 Part of ISBN: 18734863 01681656 CONTRIBUTORS: Zhang, J.; Zhang, X.; Mao, Y.; Jin, B.; Guo, Y.; Wang, Z.; Chen, T. Integrating CRISPR-Enabled Trackable Genome Engineering and Transcriptomic Analysis of Global Regulators for Antibiotic Resistance Selection and Identification in Escherichia coli mSystems 2020-04-21 | Journal article DOI: 10.1128/msystems.00232-20 Part of ISSN: 2379-5077 Biochemical engineering in China Reviews in Chemical Engineering 2019 | Journal article DOI: 10.1515/revce-2017-0035 EID: 2-s2.0-85062867883 Part of ISBN: 01678299 CONTRIBUTORS: Ding, M.; Chen, B.; Ji, X.; Zhou, J.; Wang, H.; Tian, X.; Feng, X.; Yue, H.; Zhou, Y.; Wang, H. et al. Combinatorial expression of different β-carotene hydroxylases and ketolases in Escherichia coli for increased astaxanthin production Journal of Industrial Microbiology and Biotechnology 2019 | Journal article DOI: 10.1007/s10295-019-02214-1 EID: 2-s2.0-85068883945 Part of ISBN: 14765535 13675435 CONTRIBUTORS: Wu, Y.; Yan, P.; Liu, X.; Wang, Z.; Tang, Y.-J.; Chen, T.; Zhao, X.

学术兼职

国际代谢工程学会(IMES)会员，中国化工学会会员，中国微生物学会会员；天津微生物学会监事国家自然科学基金评审人，教育部学位与研究生教育评估网评专家；国际期刊Frontiers in Bioengineering and Biotechnology，associate editor； Metabolic Engineeing, Biotechnology for Biofuels，Bioresource Technology，ACS Synthetic Biology, Biotechnology and Bioengineering, Micirobial Cell Factories， Journal of Biotechnology，Biotechnology Journal，Current Microbiology、生物工程学报，化工学报、化学进展等国内外学术期刊审稿人。