Spiegel, David A. - Yale University - Department of Chemistry

个人简介

American Chemical Society Committee on Science Young Investigator Awardee, 2013 Department of Defense CDMRP Breast Cancer Era of Hope Scholar Award, 2013 ACS Medicinal Chemistry Young Investigator Award Symposium Speaker, 2012 Bristol-Myers Squibb Innovation Award, 2012 Novartis Early Career Award in Organic Chemistry (one of two recipients worldwide), 2011 Kavli Institute Frontiers of Science Fellowship, 2011 Alfred P. Sloan Foundation Fellowship, 2011 Nature Chemical Biology Grand Challenges Essay Contest, 2010 Bill and Melinda Gates Foundation Grand Challenges Explorations Award, 2009-present Ellison Medical Foundation New Scholar Award, 2008-present NIH Director's New Innovator Award, 2007-present Dreyfus New Faculty Award 2007-present NIH Ruth L. Kirchstein National Research Service Award Fellowship, 2005-07 NIH Cancer Education Program Fellowship, 2001-02 Rotary Foundation Walter D. Head Memorial Fellowship for Study Abroad, 1995-96 Barry M. Goldwater Fellowship for Excellence in Science, 1994-95 Rockefeller University Summer Undergraduate Research Fellowship, 1994 John Harvard Fellowship (awarded by semester), 1992-95

研究领域

Organic Chemistry/Chemical Biology/Synthetic Chemistry

近期论文

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"Chemically Synthesized Molecules with the Targeting and Effector Functions of Antibodies." McEnaney, P. J., Fitzgerald, K. J., Zhang, A. X., Douglass, Jr., E. F., Shan, W., Balog, A., Kolesnikova, M. D., Spiegel, D. A. J. Am. Chem. Soc., 2014, 136 (52), 18034-18043 "Illuminating HIV gp120–Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules." Parker, C. G.; Dahlgren, M. K.; Tao, R. N.; Li, D. T.; Douglass, E. F.; Shoda, T.; Jawanda, N.; Spasov, K. A.; Lee, S.; Zhou, N.; Domaoal, R. A.; Sutton, R. E.; Anderson, K. S.; Jorgensen, W. L.; Krystal, M.; Spiegel, D. A. Chem. Sci., 2014, 5 (6), 2311-2317. "Pushing the Bacterial Envelope: Strategies for Re-engineering Bacterial Surfaces with Heterologous Proteins and Sugars." Gautam, S.; Spiegel, D. A. In Micro- and Nanoengineering of the Cell Surface, Weian Zhao and Jeffrey Karp, Eds. (Elsevier, 2013), in press. "Reversal of Hypertriglyceridemia, Fatty Liver Disease and Insulin Resistance by a Novel Liver-targeted Mitochondrial Uncoupler." Perry, R. J.; Kim, T.; Zhang, X-M., Lee, H-Y.; Pesta, D.; Zhang, D.; Rahimi, Y.; Jurczak, M.; Cline, G. C.; Spiegel, D. A.; Shulman, G. I. Cell Metabolism, 2013, 18 (5), 740-748. "Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators" Jakobsche, C. E.; Parker, C. G.; Tao, R. N.; Kolesnikova, M. D.; Douglass, Jr. E. F.; Spiegel, D. A. ACS Chem. Biol., 2013, 8 (11), 2404-2411. "A "Turn-On" Fluorescent Sensor for Methylglyoxal" Wang, T.; Douglass, Jr. E. F.; Fitzgerald, K. J.; Spiegel, D. A. J. Am. Chem. Soc., 2013, 135, 12429-12433. Also featured in C&EN. "Serendipitous Discovery of Two Highly Selective Inhibitors of Bacterial Luciferase" Kim, T.; Spiegel, D. A. Tetrahedron, 2013, 36, 7692-7698. "A Call to ARMs: The Promise of Small Molecule Immunotherapeutics for Treating Human Disease" Spiegel, D. A. Expert Review of Clinical Pharmacology, 2013, 6, 223-225. "A Comprehensive Mathematical Model for Three-Body Binding Equilibria" Douglass, E. F.; Miller, C. J.; Sparer, G.; Shapiro, H.; Spiegel, D. A. J. Am. Chem. Soc., 2013, 135, 6092-6099 "Synthetic Immunology" McEnaney, P.; Padukkavidana, T.; Spiegel, D. A. In Biotherapeutics: Recent Developments using Chemical and Molecular Biology, Lyn Jones, Ed. (Royal Society of Chemistry, 2013), 1-35. "Exterior Design: Strategies for Redecorating the Bacterial Surface with Small Molecules" Gautam, S.; Gniadek, T. J.; Kim, T., Spiegel, D. A. Trends in Biotechnology, 2013, 31, 258-267. "The Unique Reactivity of N-phenacyl-derived Thiazolium Salts Toward Alpha-dicarbonyl Compounds" Kim, T.; Spiegel, D. A. Rejuvenation Research, 2013, 16(1), 45-50 "Antibody-recruiting Molecules: An Emerging Paradigm for Engaging Immune Function in Treating Human Disease" McEnaney, P. J.; Parker, C. G.; Zhang, A. X.; Spiegel, D. A. ACS Chem. Biol., 2012, 1139-1151 "Exploring Post-translational Arginine Modification Using Chemically Synthesized Methylglyoxal Hydroimidazolones" Wang, T.; Kartika, R.; Spiegel, D. A. J. Am. Chem. Soc., 2012, 134, 8958–8967. "Reprogramming Urokinase into an Antibody-Recruiting Anticancer Agent" Jakobsche, C. E.; McEnaney, P. J.; Zhang, A. X.; Spiegel, D. A. ACS Chem. Biol., 2012, 316–321. "A Chemically Induced Vaccine Strategy for Prostate Cancer" Dubrovska, A.; Kim, C.; Elliott, J.; Shen, W.; Kuo, T.-H.; Koo†, D.-I.; Li, C.; Tuntland, T.; Chang, J.; Groessl, T.; Wu, X.; Gorney, V.; Ramirez-Montagut, T.; Spiegel, D. A.; Cho, C. Y.; Schultz, P. G. ACS Chem. Biol., 2011, 1223-1231. "Rapid Clearance of Transfused Murine RBCs is Associated with Recipient Cytokine Storm and Enhanced Alloimmunogenicity" Hendrickson, J. E.; Hod, E. A.; Cadwell, C. M.; Eisenbarth, S. C.; Spiegel, D. A.; Tormey, C. A.; Spitalnik, S. L.; Zimring, J. C. Transfusion 2011, 51, 2445–2454. "Synthetic Immunology to Engineer Human Immunity" Spiegel, D. A. Nature Chemical Biology 2010, 6, 871-872. Chosen as one of eight recipients of the 2010 Grand Challenges in Chemical Biology Competition. "A Biosynthetic Strategy for Re-engineering the S. aureus Cell Wall with Non-Native Small Molecules" Nelson, J. W.; Chamessian, A. G.; McEnaney, P. J., Kazmierczak, B. I.; Spiegel, D. A. ACS Chem. Biol., 2010, 5, 1147-1155. (see also addition 2011, 971) Highlighted as Leading Edge Article in Cell, 2010, 143, 493. "A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules" Zhang, A. X.; Murelli, R. P.; Barinka, C.; Michel, J.; Cocleaza, A.; Jorgensen, W. L.; Lubkowski, J.; Spiegel, D. A. J. Am. Chem. Soc. 2010, 132, 12711-12716 Featured as Research Highlight in Nature Chemical Biology, 2010, 6, 698, and as a Science and Technology Concentrate in Chemical and Engineering News C&E News 2010, 88 [36], 58. "Chemical Control over Immune Recognition: A Class of Antibody-Recruiting Small Molecules That Target Prostate Cancer" Murelli, R. P.; Zhang, A. X.; Michel, J.; Jorgensen, W. L.; Spiegel, D. A. J. Am. Chem. Soc. 2009, 131, 17090-17092. Featured in ChemBioChem as the focus of a review article entitled "Antibody Recruiting Small Molecules: A New Option for Prostate Tumor Therapy by PSMA Targeting", 2010, 11, 1052-4. Also featured as a news story in ACS Chem. Biol., 2009, 4, 975. "Spatiotemporal Control over Molecular Delivery and Cellular Encapsulation from Electropolymerized Micro- and Nanopatterned Surfaces" Stern E.; Jay, S. M.; Demento, S. L.; Murelli, R. P.; Reed, M. A.; Malinski, T.; Spiegel, D. A.; Mooney, D. J.; Fahmy, T. M. Adv. Funct. Mater. 2009, 19, 2888-2895. "An Antibody-Recruiting Small Molecule That Targets HIV gp120" Parker, C. G.; Domaoal, R. A.; Anderson, K. S.; Spiegel, D. A. J. Am. Chem. Soc. 2009, 131, 16392-16394.