Schepartz, Alanna - Yale University - Department of Chemistry

个人简介

Presidential Award for Undergraduate Research, SUNY@Albany, 1982 Award for Excellence in Teaching, Columbia University, 1983 Pegram Award for Graduate Research, Columbia University, 1986 National Institutes of Health Postdoctoral Fellowship, 1987 David and Lucile Packard Foundation Fellow, 1990 Eli Lilly Biochemistry Fellow, 1991 Morse Faculty Fellow, Yale University, 1991 National Science Foundation Presidential Young Investigator Award, 1991 Camille and Henry Dreyfus Teacher-Scholar Award, 1993 Alfred P. Sloan Research Fellowship, 1994 A.C.S. Arthur C. Cope Scholar Award, 1995 A.C.S. Eli Lilly Award in Biological Chemistry, 1997 Dylan Hixon '88 Award for Teaching Excellence in the Natural Sciences, Yale University, 1999 Agnes Fay Morgan Research Award, 2002 Howard Hughes Medical Institute Professor, 2002-2007 Editorial Advisory Board, Journal of the American Chemical Society, 2003-2005 Associate Editor, Journal of the American Chemical Society, 2005-present Frank H. Westheimer Prize Medal, Harvard University, 2008 ACS Chemical Biology Prize, 2010 Alexander M. Cruickshank Prize, 2010 American Academy of Arts & Sciences Fellow, 2010 American Chemical Society Fellow, 2010 Ronald Breslow Award for Achievement in Biomimetic Chemistry, 2012 Co-Editor, Molecular Imaging, Current Opinion in Chemical Biology, 2012 Co-Editor, Supramolecular Chemistry for Biology, Materials and Medicine, Israel Journal of Chemistry, 2013 Elected Member, National Academy of Sciences, 2014

研究领域

Organic Chemistry/Chemical Biology/Biophysical Chemistry

近期论文

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Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides. J.R. LaRochelle, G.B. Cobb, A. Steinauer, E. Rhoades, & A. Schepartz, J. Am. Chem. Soc. 2015, epub ahead of print. DOI: 10.1021/ja510391n Positive allostery in metal ion binding by a cooperatively folded β-peptide bundle. J.P. Miller, M.S. Melicher, & A. Schepartz, J. Am. Chem. Soc. 2014, 136, 14726-9. DOI: 10.1021/ja508872q Influence of macrocyclization on allosteric, juxtamembrane-derived, stapled peptide inhibitors of EGFR. J.K. Sinclair & A. Schepartz, Org. Lett. 2014, 16, 4916-9. DOI: 10.1021/ol502426b Inhibiting epidermal growth factor receptor at a distance. J.K. Sinclair, E.V. Denton, & A. Schepartz, J. Am. Chem. Soc. 2014, 136, 11232-5. DOI: 10.1021/ja504076t Interactions of AsCy3 with cysteine-rich peptides. S.C. Alexander & A. Schepartz, Org. Lett. 2014, 16, 3824-3827. DOI: 10.1021/ol501721j Hochaufgelöste Visualisierung des Golgi-Apparats in lebenden Zellen mit einem bioorthogonalen Ceramid. R.S. Erdmann, H. Takakura, A.D. Thompson, F. Rivera-Molina, E.S. Allgeyer, J. Bewersdorf, D.K. Toomre, & A. Schepartz, Angew. Chem. Weinheim. Bergstr. Ger. 2014, 126, 10407-12. DOI: 10.1002/ange.201403349 Super-resolution imaging of the golgi in live cells with a bio-orthogonal ceramide probe. R.S. Erdmann, H. Takakura, A.D. Thompson, F. Rivera-Molina, E.S. Allgeyer, J. Bewersdorf, D.K. Toomre, & A. Schepartz, Angew. Chem. Int. Ed. Engl. 2014, 53, 10242-6. DOI: 10.1002/anie.201403349. Highlight: Chosen as a "Hot Paper". Chemistry and the BRAIN initiative. A.M. Andrews, A. Schepartz, J.V. Sweedler, & P.S. Weiss, J. Am. Chem. Soc. 2014, 136, 1-2. DOI: 10.1021/ja4118347 Design and high-resolution structure of a ß3-peptide bundle catalyst. P.S.P. Wang, J.B. Nguyen, & A. Schepartz, J. Am. Chem. Soc. 2014, 136, 6810-6813. DOI: 10.1021/ja5013849 Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics. J.M. Holub, J.R. LaRochelle, J.S. Appelbaum, & A. Schepartz, Biochemistry 2013, 52, 9036-9046. Combined lewis acid and bronstead acid-mediated reactivity of glycosyl trichloroacetimidate donors. N.D. Gould, C.L. Allen, B.C. Nam, A. Schepartz, & S.J. Miller, Carbohydr. Res. 2013, 382, 36-42. A β-peptide agonist of the GLP-1 receptor, a class B GPCR. E.V. Denton, C.J. Craig, R.L. Pongratz, J.S. Appelbaum, A.E. Doerner, A. Narayanan, G.I. Shulman, G.W. Cline, & A. Schepartz, Org. Lett. 2013, 15, 5318-5321. A β-boronopeptide bundle of known structure as a vehicle for polyol recognition. M.S. Melicher, J. Chu, A.S. Walker, S.J. Miller, R.H.G. Baxter, & A. Schepartz, Org. Lett. 2013, 15, 5048-5051. Remodeling a ß-peptide bundle. M.A. Molski, J.L. Goodman, F-C. Chou, D. Baker, R. Das, & A. Schepartz, RSC Chem. Sci. 2013, 4, 319-324. Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation. R.A. Scheck, M.A. Lowder, J.S. Appelbaum, & A. Schepartz, ACS Chem. Bio. 2012, 7, 1367-1376. Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm. J.S. Appelbaum, J.M. LaRochelle, B.A. Smith, D.M. Balkin, J.M. Holub, & A. Schepartz, Chem. Bio. 2012, 19, 819-830. Rewiring kinase specificity with a synthetic adaptor protein. E.M. Hobert & A. Schepartz, J. Am. Chem. Soc. 2012, 134, 3976-3978. Relationship between side-chain branching and stoichiometry in ß3-peptide bundles. P.S. Wang, C.J. Craig, & A. Schepartz, Tetrahedron 2012, 68, 4342-4345. Visualizing protein partnerships in living cells and organisms. M.A. Lowder, J.S. Appelbaum, E.M. Hobert, & A. Schepartz, Curr. Opin. Chem. Biol. 2011, 15, 781-788. Molecular imaging: sine labore nihil. A. Schepartz & R.L. Gonzalez Jr., Curr. Opin. Chem. Biol. 2011, 15, 749-751. Surveying protein structure and function using bis-arsenical small molecules. R.A. Scheck & A. Schepartz, Acc. Chem. Res. 2011, 44, 654-665. Enhancing ß3-peptide bundle stability by design. C.J. Craig, J.L. Goodman, & A. Schepartz, ChemBioChem 2011, 12, 1035-1038. Direct visualization of protein association in living cells with complex-edited electron microscopy. R.J. Dexter & A. Schepartz, Angew. Chem. 2010, 49, 7952-7954. Visualizing tyrosine kinase activity with bipartite tetracysteine display. S. Ray-Saha & A. Schepartz, ChemBioChem. 2010, 11, 2089-2091. ß-Peptide bundles with fluorous cores. M.A. Molski, J.L. Goodman, C.J. Craig, H. Meng, K. Kumar, & A. Schepartz, J. Am. Chem. Soc. 2010, 132, 3658-3659. Bridged ß3-peptide inhibitors of p53-hDM2 complexation: Correlation between affinity and cell permeability. A.D. Bautista, J.S. Appelbaum, C.J. Craig, J. Michel, & A. Schepartz, J. Am. Chem. Soc. 2010, 132, 2904-2906. Bipartite tetracysteine display requires site flexibility for ReAsH coordination. J.L. Goodman, D.B. Fried, & A. Schepartz, ChemBioChem 2009, 10, 1644-1647. In silico improvement of ß3-peptide inhibitors of p53·hDM2 and p53·hDMX. J. Michel, E.A. Harker, J. Tirado-Rives, W. Jorgensen, & A. Schepartz, J. Am. Chem. Soc. 2009, 131, 6356-6357. Identification of a ß(3)-peptide HIV fusion inhibitor with improved potency in live cells. A.D. Bautista, O.M. Stephens, L. Wang, R.A. Domaoal, K.S. Anderson, & A. Schepartz, Bioorg. Med. Chem. Lett. 2009, 19, 3736-3738. Cell-permeable ß-peptide inhibitors of p53/hDM2 complexation. E.A. Harker & A. Schepartz, ChemBioChem 2009, 10, 990-993. ß-peptides with improved affinity for hDM2 and hDMX. E.A. Harker, D.S. Daniels, D.A. Guarracino, & A. Schepartz, Bioorg. Med. Chem. 2009, 17, 2038-2046. Selective recognition of protein tetraserine motifs with a cell-permeable, pro-fluorescent bis-boronic acid. T.L. Halo, J. Appelbaum, E.M. Hobert, D.M. Balkin, & A. Schepartz, J. Am. Chem. Soc. 2009, 131, 438-439. Tetrameric ß(3)-peptide bundles. J.L. Goodman, M.A. Molski, J. Qui, & A. Schepartz, ChembioChem 2008, 9, 1576-1578. Minimally cationic cell-permeable miniature proteins via alpha-helical arginine display. B. Smith, D.S. Daniels, A. Coplin, G. Jordan, L. McGregor, & A. Schepartz, J. Am. Chem. Soc. 2008, 130, 2948-2949.