Rothman, James E. - Yale University - Department of Chemistry

个人简介

Scholar of the House in Yale College, 1970 71 Andrew W. Mellon Fellow, 1979 82 Dreyfus Fndn. Teacher Scholar, 1981 86 The Eli Lilly Award for Fundamental Res. in Biol. Chem., 1986 The Passano Young Scientist Award, 1986 The Alexander Von Humboldt Award, 1989 The Heinrich Wieland Prize, 1990 Member, Natl. Acad. of Sciences, 1993 The Rosenstiel Award in Biomedical Sciences, 1994 Fellow, Amer. Acad. Arts & Sciences, 1994 The V.D. Mattia Award, 1994 The Fritz Lipmann Award, 1995 Member, Institute of Med., Natl. Acad. of Sciences, 1995 Dr. h.c., Univ. of Regensburg, 1995 Foreign Assoc., European Molec. Biol. Org’n., 1995 Mayor’s Award For Excellence in Sci. & Tech., 1995 Gairdner Fndn. Internat’l. Award, 1996 King Faisal Internat’l. Prize in Science, 1996 The Harden Medal, 1997 The Lounsbery Award, Natl. Acad. of Sciences, 1997 The Feodor Lynen Award, 1997 Dr. h.c., Univ. of Geneva, 1997 The Heineken Prize, 2000 The Otto-Warburg Medal, 2001 The Lasker Award – Basic Medical Research, 2002 The Louisa Gross Horwitz Prize, 2002

研究领域

Biophysical Chemistry/Chemical Biology

近期论文

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The principle of membrane fusion in the cell (Nobel lecture). Rothman JE. Angew Chem Int Ed Engl. 2014 Nov 17;53 (47) :12676-94. Epub 2014 Aug 1. PMID: 25087728 The Golgi ribbon structure facilitates anterograde transport of large cargoes. Lavieu G, Dunlop MH, Lerich A, Zheng H, Bottanelli F, Rothman JE. Mol Biol Cell. 2014 Oct 1;25 (19) :3028-36. Epub 2014 Aug 7. PMID: 25103235 Calcium sensitive ring-like oligomers formed by synaptotagmin. Wang J, Bello O, Auclair SM, Wang J, Coleman J, Pincet F, Krishnakumar SS, Sindelar CV, Rothman JE. Proc Natl Acad Sci U S A. 2014 Sep 23;111 (38) :13966-71. Epub 2014 Sep 8. PMID: 25201968 Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins. Zorman S, Rebane AA, Ma L, Yang G, Molski MA, Coleman J, Pincet F, Rothman JE, Zhang Y. Elife. 2014 Sep 1;3 :e03348. Epub 2014 Sep 1. PMID: 25180101 Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo. Cho RW, Kümmel D, Li F, Baguley SW, Coleman J, Rothman JE, Littleton JT. Proc Natl Acad Sci U S A. 2014 Jul 15;111 (28) :10317-22. Epub 2014 Jun 30. PMID: 24982161 A half-zippered SNARE complex represents a functional intermediate in membrane fusion. Li F, Kümmel D, Coleman J, Reinisch KM, Rothman JE, Pincet F. J Am Chem Soc. 2014 Mar 5;136 (9) :3456-64. Epub 2014 Feb 18. PMID: 24533674 Membrane adhesion dictates Golgi stacking and cisternal morphology. Lee I, Tiwari N, Dunlop MH, Graham M, Liu X, Rothman JE. Proc Natl Acad Sci U S A. 2014 Feb 4;111 (5) :1849-54. Epub 2014 Jan 21. PMID: 24449908 Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin. Krishnakumar SS, Kümmel D, Jones SJ, Radoff DT, Reinisch KM, Rothman JE. Biophys J. 2013 Dec 3;105 (11) :2507-16. PMID: 24314081 Inter-Golgi transport mediated by COPI-containing vesicles carrying small cargoes. Pellett PA, Dietrich F, Bewersdorf J, Rothman JE, Lavieu G. Elife. 2013 Oct 1;2 :e01296. Epub 2013 Oct 1. PMID: 24137546 COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function. Thiam AR, Antonny B, Wang J, Delacotte J, Wilfling F, Walther TC, Beck R, Rothman JE, Pincet F. Proc Natl Acad Sci U S A. 2013 Aug 13;110 (33) :13244-9. Epub 2013 Jul 30. PMID: 23901109 Stapled Golgi cisternae remain in place as cargo passes through the stack. Lavieu G, Zheng H, Rothman JE. Elife. 2013 Jun 4;2 :e00558. Epub 2013 Jun 4. PMID: 23755362 Preparation and characterization of SNARE-containing nanodiscs and direct study of cargo release through fusion pores. Shi L, Howan K, Shen QT, Wang YJ, Rothman JE, Pincet F. Nat Protoc. 2013 May;8 (5) :935-48. Epub 2013 Apr 18. PMID: 23598444 Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Gao Y, Zorman S, Gundersen G, Xi Z, Ma L, Sirinakis G, Rothman JE, Zhang Y. Science. 2012 Sep 14;337 (6100) :1340-3. Epub 2012 Aug 16. PMID: 22903523 Fusion of single proteoliposomes with planar, cushioned bilayers in microfluidic flow cells. Karatekin E, Rothman JE. Nat Protoc. 2012 Apr 19;7 (5) :903-20. Epub 2012 Apr 19. PMID: 22517259 SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Shi L, Shen QT, Kiel A, Wang J, Wang HW, Melia TJ, Rothman JE, Pincet F. Science. 2012 Mar 16;335 (6074) :1355-9. PMID: 22422984 Molecular mechanism of protein folding in the cell. Rothman JE, Schekman R. Cell. 2011 Sep 16;146 (6) :851-4. Epub 2011 Sep 9. PMID: 21907398 Complexin cross-links prefusion SNAREs into a zigzag array. Kümmel D, Krishnakumar SS, Radoff DT, Li F, Giraudo CG, Pincet F, Rothman JE, Reinisch KM. Nat Struct Mol Biol. 2011 Jul 24;18 (8) :927-33. Epub 2011 Jul 24. PMID: 21785414 Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Li F, Pincet F, Perez E, Giraudo CG, Tareste D, Rothman JE. Nat Struct Mol Biol. 2011 Jul 24;18 (8) :941-6. Epub 2011 Jul 24. PMID: 21785413 A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Krishnakumar SS, Radoff DT, Kümmel D, Giraudo CG, Li F, Khandan L, Baguley SW, Coleman J, Reinisch KM, Pincet F, Rothman JE. Nat Struct Mol Biol. 2011 Jul 24;18 (8) :934-40. Epub 2011 Jul 24. PMID: 21785412 The future of Golgi research. Rothman JE. Mol Biol Cell. 2010 Nov 15;21 (22) :3776-80. PMID: 21079007