Pyle, Anna M. - Yale University - Department of Chemistry

个人简介

Woodrow Wilson School Program in Science Policy, Princeton University, 1983-1985 Magna cum laude in Chemistry, Princeton University, 1985 J. Malcolm Miller Teaching Award, Columbia University, 1986 Pegram Award, Columbia University, 1989 Jane Coffin Childs Memorial Fund Postdoctoral Fellowship, 1990-1992 Irma T. Hirschl and Monique Weill-Caulier Career Scientist Award, 1992-1997 Searle Scholars Award, 1993-1996 Beckman Young Investigator, 1994-1996 NSF National Young Investigator Award, 1994-1999 Investigator, Howard Hughes Medical Institute, 1997-present Mayor’s Award for Excellence in Science and Technology, New York, 2002 Member of the American Academy of Arts and Sciences, 2005-present Editor, Journal of Molecular Biology, 2007-present Fellow of the American Association for the Advancement of Science, 2007

研究领域

Biophysical Chemistry/Chemical Biology

近期论文

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Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells Ellen F. Foxman, James A. Storer, Megan E. Fitzgerald, Bethany R. Wasik, Lin Hou, Hongyu Zhao, Paul E. Turner, Anna Marie Pyle and Akiko Iwasaki Proc. Natl. Acad. Sci. USA 2015 (112) : 827-832 Looking at LncRNAs with the Ribozyme Toolkit Anna Marie Pyle Mol Cell. 2014 (56) : 13-17 The RIG-I ATPase core has evolved a functional requirement for alosteric stabilization by the pincer domain David Rawling, Andrew Kohlway, Dahai Luo, Steve C. Ding and Anna Marie Pyle Nucleic Acids Res. 2014 (42) : 11601-11611 The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus Andrew Kohlway, Nathan Pirakitikulr, Steve C. Ding, Feng Yang, Dahai Luo, Brett D. Lindenbach and Anna Marie Pyle J Virol. 2014 (18) : 10970-10974 An evolving arsenal: viral RNA detection by RIG-I-like receptors Megan Fitzgerald, David C. Rawling, Adriana Vela and Anna Marie Pyle Curr Opin Microbiol. 2014 (20) : 76-81 Parts, assembly and operation of the RIG-I family of motors David C. Rawling and Anna Marie Pyle Curr Opin Struct Biol. 2014 (25) : 25-33 Principles of ion recognition in RNA: insights from the group II intron structures Marco Marcia and Anna Marie Pyle RNA 2014 (20) : 516-27 Dicer-related helicase 3 (DRH-3) forms an obligate dimer for recognizing 22G-RNA Megan Fitzgerald, Adriana Vela and Anna Marie Pyle Nucleic Acids Res. 2014 (42) : 19-30 Coordinating the party: assembly factors and ribogenesis Anna Marie Pyle Mol Cell. 2013 (52) : 469-470 Visualizing the ai5γ group IIB intron Srinivas Somarowthu, Michal Legiewicz, Kevin S. Keating and Anna Marie Pyle Nucleic Acids Res. 2013 (42) : 1947-58 Solving nucleic acid structures by molecular replacement: examples from group II intron studies Marco Marcia, Elisabeth Humphris-Narayaan, Kevin S. Keating, Srinivas Somarowthu, K. Rajashankar and Anna Marie Pyle Acta Crystallogr D Biol Crystallogr 2013 (69) : 2174-2185 Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain Andrew Kohlway, Nathan Pirakitikulr, Francisco N. Barrera, Olga Potapova, Donald M. Engelman, Anna Marie Pyle and Brett D. Lindenbach J Virol. 2014 (88) : 628-42 Non-coding RNAs: A Story of Networks and Long Distance Relationships M. Ostankovitch and Anna Marie Pyle J. Mol. Biol. 2013 (425) : 3577-3581 Defining the functional determinants for RNA surveillance by RIG-I Andrew Kohlway, Dahai Luo, David C. Rawling, Steve C. Ding and Anna Marie Pyle EMBO Rep. 2013 (14) : 772-779 Predicted group II intron lineages E and F comprise catalytically active ribozymes Vivian Nagy, Nathan Parakitikulr, Katherine I. Zhou, Isabel Chillon, Jerome Luo and Anna Marie Pyle RNA 2013 (19) : 1266-1278 Now on display: a gallery of group II intron structures at different stages of catalysis Marco Marcia, Srinivas Somarowthu and Anna Marie Pyle Mob DNA 2013 (4) : 14 Duplex RNA activated ATPases (DRAs): Platforms for RNA sensing signaling and processing Dahai Luo, Andrew Kohlway and Anna Marie Pyle RNA Biol. 2013 (10) : 111-120 Visualizing group II intron catalysis through the stages of splicing Marco Marcia and Anna Marie Pyle Cell 2012 (151) : 497-507 The thermodynamic basis for viral RNA detection by the RIG-I innate immune sensor Adriana Vela, Olga Fedorova, Steve O. Ding and Anna Marie Pyle J. Biol. Chem. 2012 (287) : 42564-42573 Visualizing the determinants of viral RNA recognition by innate immune sensor RIG-I Dahai Luo, Andrew Kohlway, Adriana Vela and Anna Marie Pyle Structure 2012 (20) : 1983-1988 RCrane: semi-automated RNA model building Kevin S. Keating and Anna Marie Pyle Acta Cryst. 2012 (68) : 985-995 Molecular mechanics of RNA translocases Steve C. Ding and Anna Marie Pyle Methods Enzymol. 2012 (511) : 131-147