Chang, Michelle C. - University of California, Berkeley

个人简介

Professor of Chemistry B.S., Biochemistry, B.A., French Literature, University of California, San Diego (1997) National Science Foundation Predoctoral Fellow (1997-2000) M.I.T./Merck Foundation Predoctoral Fellow (2000-2002) Ph.D. Massachusetts Institute of Technology (2004) Jane Coffin Childs Postdoctoral Fellow, University of California, Berkeley (2004-2007) Camille and Henry Dreyfus Foundation New Faculty Award (2007) Arnold and Mabel Beckman Foundation Young Investigator Award (2008) Technology Review TR35 Young Innovator Award (2008) BayBio Rising Star Award (2008) NSF CAREER (2009) Agilent Early Career Award (2010) Hellman Foundation Faculty Award (2010) American Chemical Society-Sociedade Brasileira de Química Young Talents in Science Award (2011) NIH New Innovator Award (2011) DARPA Young Faculty Award (2012) Iota Sigma Pi Agnes Fay Morgan Award (2012) Paul Saltman Award in Bioinorganic Chemistry (2013) 3M Young Faculty Award (2013) Camille Dreyfus Teacher-Scholar Award (2013)

研究领域

Biochemistry, Chemical Biology, and Synthetic Biology — Designing new biosynthetic pathways for in vivo cellular production of biofuels and pharmaceuticals Our research laboratory utilizes the approaches of mechanistic biochemistry, molecular and cell biology, metabolic engineering, and synthetic biology to address problems in energy and human health. We design and create new biosynthetic pathways in microbial hosts for in vivo production of biofuels from abundant crop feedstocks and pharmaceuticals from natural products or natural product scaffolds. A unifying theme of all of our projects is a focus on gaining a detailed molecular understanding of how living cells control enzymatic processes within the context of the entire metabolic network. Specific projects under current investigation include (i) the in vivo production of biofuels from plant biomass, and (ii) the development of new biosynthetic methods for selective, catalytic C-F bond formation under mild conditions.

近期论文

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H. Dong, M.C.Y. Chang, "Structural basis for branched substrate selectivity in a ketoreductase from Ascaris suum", ACS Catal. 2021, 11, 8948-8955. [pdf] [SI] H. Dong, S. Liffland, M.A. Hillmyer, M.C.Y. Chang, "Engineering in vivo production of α-branched polyesters", J. Am. Chem. Soc. 2019, 141, 16877-16883. [pdf] [SI] M.E. Neugebauer, K.H. Sumida, J.G. Pelton, J.L. McMurry, J.A. Marchand, M.C.Y. Chang, "A family of radical halogenases for the engineering of amino-acid-based products", Nat. Chem. Biol. 2019, 15, 1009-1016. [pdf] [SI] [Nature blog] J. Fang, D. Hait, M. Head-Gordon, M.C.Y. Chang, "Chemoenzymatic platform for synthesis of chiral organofluorines based on type II aldolases", Angew. Chem. Int. Ed. 2019, 58, 11841-11845. [pdf] [SI] J.A. Marchand, M.E. Neugebauer, M.C. Ing, C.-I. Lin, J.G. Pelton, M.C.Y. Chang, "Discovery of a pathway for terminal-alkyne amino acid biosynthesis", Nature 2019, 567, 420-424. [pdf] [C&E News] [Nature blog] [F1000Prime] A.M. Weeks, N. Wang, J.G. Pelton, M.C.Y. Chang, "Entropy drives selective fluorine recognition in the fluoroacetyl–CoA thioesterase from Streptomyces cattleya", Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E2193-E2201. [pdf] [SI] M.R. Blaisse, B. Fu, M.C.Y. Chang, "Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases", Biochemistry 2018, 57, 3155-3166. [pdf] [SI] J.L. McMurry, M.C.Y. Chang, "Fluorothreonyl-tRNA deacylase prevents mistranslation in the organofluorine producer Streptomyces cattleya", Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 11920-11925. [pdf] [SI] M.R. Blaisse, H. Dong, B. Fu, M.C.Y. Chang, "Discovery and engineering of pathways for production of α-branched organic acids", J. Am. Chem. Soc. 2017, 139, 14526-14532. [pdf] [SI] B.W. Thuronyi, T.M. Privalsky, M.C.Y. Chang, "Engineered fluorine metabolism and fluoropolymer production in living cells", Angew. Chem. Int. Ed. 2017, 56, 13637-13640. [pdf] [SI] [Chemistry World] [C&E News] O. Ad, B.W. Thuronyi, M.C.Y. Chang, "Elucidating the mechanism of fluorinated extender unit loading for improved production of fluorine-containing polyketides", Proc. Natl. Acad. Sci. U.S.A. 2017, 114, E660-E668. [pdf] [SI] V.Y. Yu, M.C.Y. Chang, "High-yield chemical synthesis by reprogramming central metabolism", Nat. Biotech. 2016, 34, 1128-1129. D.M. Hersey, X. Ren , R.A. Melnyk, P.J. Browne, E. Ozyamak, S.R. Jones, M.C.Y. Chang, J.H. Hurley, A. Komeili, "MamO Is a repurposed serine protease that promotes magnetite biomineralization through direct transition metal binding in magnetotactic bacteria", PloS Biol. 2016, 14, e1002402. [pdf] [SI] E.M. Nichols, J.J. Gallagher, C. Liu, Y. Su, J. Resasco, Y. Yi, Y. Sun, P. Yang, M.C.Y. Chang, C.J. Chang, "Hybrid bioinorganic approach to solar-to-chemical conversion", Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 11461-11466. [pdf] [SI] [LBNL News Story] [ScienceDaily News Story] [Adaptive Scientist News Story] B.W. Thuronyi, M.C.Y. Chang, "Synthetic biology approaches to fluorinated polyketides", Acc. Chem. Res. 2015, 48, 584-592. C. Liu, J.J. Gallagher, K.K. Sakimoto, E.M. Nichols, C.J. Chang, M.C.Y. Chang, P. Yang, "Nanowire–bacteria hybrids for unassisted solar carbon dioxide fixation to value-added chemicals", Nano Lett. 2015, 15, 3634-3639. [pdf] [SI] [LBNL News Story] [Tech Times News Story] [Science Times News Story] [News Everyday News Story] [Huffington Post article] [KALWRadio] S.R. Jones, T.D. Wilson, M.E. Brown, L. Rahn-Lee, Y. Yu, L.L. Fredriksen, E. Ozyamak, A. Komeili, M.C.Y. Chang, "Genetic and biochemical investigations of the role of MamP in redox control of iron biomineralization in Magnetospirillum magneticum", Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 3904-3909. [pdf] [SI] M.C. Walker, M.C.Y. Chang, "Natural and engineered biosynthesis of fluorinated natural products", Chem. Soc. Rev. 2014, 43, 6527-6536. A.M. Weeks, N.S. Keddie, R.D.P. Wadoux, D. O'Hagan, M.C.Y. Chang, "Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase, FlK", Biochemistry 2014, 53, 2053-2063. [pdf] [SI] M.E. Brown, M.C.Y. Chang, "Exploring bacterial lignin degradation", Curr. Opin. Chem. Biol. 2014, 19, 1-7. [pdf]