Miller, Scott J. - Yale University - Department of Chemistry

个人简介

2008-Present: Irénée du Pont Professor of Chemistry, Yale University Divisional Director for Science, Yale University (2015-2017) Chair, Department of Chemistry, Yale University (2009-2015) 2006-Present: Professor of Chemistry, Yale University 2002-2006: Professor of Chemistry, Boston College 2001-2002: Associate Professor of Chemistry, Boston College 1996-2001: Assistant Professor of Chemistry, Boston College Education 1994-1996: Postdoctoral Fellow, California Institute of Technology(Advisor: Professor Robert H. Grubbs) 1989-1994: Ph.D. in Chemistry, Harvard University(Advisor: Professor David A. Evans) 1985-1989: B.A./M.A. in Chemistry, Harvard University

研究领域

Complex molecule synthesis is one of the key disciplines of modern chemical research. The development of new methods for the synthesis and derivatization of such structures is a multi-dimensional activity involving reaction design, development and application. Research in our group focuses on each of these aspects of chemical synthesis. Utilizing the architecture and design principles presented by biologically relevant structures and processes, we seek to discover new reactions and to apply new principles to the selective synthesis of complex molecules.

近期论文

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“Peptide-Catalyzed Fragment Couplings that Form Axially Chiral Non-C2-Symmetric Biaryls”Coombs, G; Sak, M. H.; Miller, S. J.; Angew. Chem. Int. Ed. 2020, 59, In Press. abstract (link is external) “Catalytic Sulfamoylation of Alcohols with Activated Aryl Sulfamates”Rapp, P. B.; Murai, K.; Ichiishi, N.; Leahy, D. K.; Miller, S. J. Org. Lett. 2020, 22, 168-174. abstract (link is external) “Co(III)-Catalyzed C-H Amidation of Dehydroalanine for the Site-Selective Structural Diversification of Thiostrepton” Scamp, R. J.; deRamon, E.; Paulson, E. K.; Miller, S. J.; Ellman, J. A.Angew. Chem. Int. Ed. 2020, 59, 890-895. abstract (link is external) “Site-Selective Nitrene Transfer to Conjugated Olefins Directed by Oxazoline Peptide Ligands” Storch, G.; van den Heuvel, N.; Miller, S. J.Adv. Synth. Catal. 2020, 362, In Press. abstract (link is external) “Catalytic Enantioselective Pyridine N-Oxidation” Hsieh, S.-Y.; Tang, Y.; Crotti, S.; Stone, E. A.; Miller, S. J. J. Am. Chem. Soc. 2019, 141, 18624-18629. abstract (link is external) “Reenginering a Reversible-Covalent Bonding Assembly to Optically Detect ee in b-Chiral Primary Alcohols” Minus, M. B.; Featherston, A. L.; Choi, S.; King, S. C.; Miller, S. J.; Anslyn, E. V.Chem 2019, 5, 3196-3206. abstract (link is external) “Light-Driven Deracemization Enabled by Excited-State Electron Transfer” Shin, N. Y.; Ryss, J. M.; Zhang, X.; Miller, S. J.; Knowles, R. R. Science 2019, 366, 364-369. abstract (link is external) “Site-Selective Acylation of Natural Products with BINOL-Derived Phosphoric Acids”Li, J.; Grosslight, S.; Miller, S. J.; Sigman, M. S.; Toste, F. D. ACS Catalysis 2019, 9, 9794-9799. abstract (link is external) “Palladium-Catalyzed Suzuki-Miyaura Reactions of Aspartic Acid Derived Phenyl Esters”Dardir, A. H.; Hazari, N.; Miller, S. J.; Shugrue, C. R. Org. Lett. 2019, 21, 5762-5766. abstract (link is external) “Translation of Diverse Aramid- and 1,3-Dicaronyl-Peptides by Wild Type Ribosomes in Vitro”Ad, O.; Hoffman, K. S.; Cairns, A. G.; Featherston, A. L.; Miller, S. J.; Söll, D.; Schepartz, A. ACS Cent. Sci. 2019, 5, 1289-1294. abstract (link is external) Editorial: “The Journal of Organic Chemistry Global Enterprise” Miller, S. J. J. Org. Chem. 2019, 84, 4953. abstract (link is external) “Terahertz Spectroscopy of Tetrameric Peptides” Neu, J.; Stone, E. A.; Spies, J.; Storch, G.; Hatano, A. S.; Mercado, B. Q.; Miller, S. J.; Schmuttenmaer, C. A. J. Phys. Chem. Lett. 2019, 10, 2624-2628. abstract (link is external) “Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration” Kwon, Y.; Li, J.; Reid, J. P.; Crawford, J. M.; Jacobs, R.; Sigman, M. S.; Toste, F. D.; Miller, S. J. J. Am. Chem. Soc. 2019, 141, 6698-6705. abstract (link is external) “Troponoid Atropisomers: Studies on the Configurational Stability of Tropone-Amide Chiral Axes” Hirsch, D. R.; Metrano, A. J.; Stone, E. A.; Storch, G.; Miller, S. J.; Murelli, R. P. Org. Lett. 2019, 21, 2412-2415. abstract (link is external) “Structure and Reactivity of Highly Twisted N-Acyl Imidazoles” Stone, E. A.; Mercado, B. Q.; Miller, S. J. Org. Lett. 2019, 21, 2346-2351. abstract (link is external) “Outer-Sphere Control for Divergent Multicatalysis with Common Catalytic Moieties” Shugrue, C. R.; Sculimbrene, B. R.; Jarvo, E. R.; Mercado, B. Q.; Miller, S. J. J. Org. Chem. 2019, 84, 199-215. abstract (link is external) “Peptide-Based Catalysts Reach the Outer Sphere through Remote Desymmetrization and Atroposelectivity” Metrano, A. J.; Miller, S. J. Acc. Chem. Res. 2019, 52, 199-215. abstract (link is external) “Phosphothreonine (pThr)–Based Multifunctional Peptide Catalysis for Asymmetric Baeyer Villiger Oxidations of Cyclobutanones” Featherston, A. L.; Shugrue, C. R.; Mercado, B. Q.; Miller, S. J. ACS Catalysis 2019, 9, 242-252. abstract (link is external) “A Chemoselective Strategy for the Late Stage Functionalization of Complex Small Molecules with Polypeptides and Proteins through Selenocysteine”Cohen, D. T.; Zhang, C.; Fadzen, C. M.; Mijalis, A. J.; Hie, L.; Johnson, K. D.; Shriver, Z.; Plante, O.; Miller, S. J.; Buchwald, S. L.; Pentelute, B. L. Nature Chem. 2019, 11, 78-75. abstract (link is external) “A Stereodynamic Redox-Interconversion Network of Vicinal Tertiary and Quaternary Carbon Stereocenters in Hydroquinone Quinone Hybrid Dihydrobenzofurans” Storch, G.; Kim, B.; Mercado, B. Q.; Miller, S. J. Angew. Chem. Int. Ed. 2018, 57, 15107-15111. abstract