个人简介

Alfred P. Sloan Fellowship, 1972 Camille and Henry Dreyfus Teacher-Scholar, 1972-77 Nobel Laureate Signature Award in Graduate Education, 1987 Prelog Medal, 1992 Catalyst Award of the Chemical Manufacturers Association, 1996

研究领域

Organic Chemistry

We are particularly interested in contributing to a new kind of rational organic synthesis, whose goal is to assemble not molecules from atoms, but crystals from molecules. Controlling crystal growth is a challenging goal of vital commercial and biomedical importance. Steve Bertman and Bart Kahr developed a technique using the polarizing microscope to read out the record of crystal growth stored in many “optically anomalous” crystals, and Jennifer Swift, Ben Negin, Miki Kunitake and Kraig Steffen have used AFM to study, in real time and with nanometer resolution, the influence of lattice structure, solvent, and additives on the dissolution of organic crystals. The inset in Figure 2 shows the AFM image of a pit on the (001) surface of crystalline benzoin. Each terrace is one molecule high. An in situ motion picture yielded kinetic data showing that a critical a-width of 860 molecular chains was required for the pit to elongate. Such direct observation will be indispensable in transforming the venerable art of crystal growth into a science.

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Photochemical Mechanism in Single Crystals: FTIR Studies of Diacyl Peroxides. M. D. Hollingsworth and J. M. McBride, in D. Volman, G. S. Hammond, and K. Gollnick, eds., Advances in Photochemistry, 1990, 15, 279-379 B. Kahr & J. M. McBride. Optically Anomalous Crystals. Angew. Chem. Int. Ed. Engl, 1992, 31, 1-26. J.A. Swift, R. Pal, & J.M. McBride. Using Hydrogen-Bonds and Herringbone Packing to Design Interfaces of 4,4'-Disubstituted meso-Hydrobenzoin Crystals. The Importance of Recognizing Unfavorable Packing Motifs. J. Am. Chem. Soc. 1998, 120, 96-104. K. L. Pate & J. M. McBride. Using Crystal Optics to Demonstrate Single-Layer Localization of a Solid-State Chain Reaction. Helv. Chim. Acta, 2000, 83, 2352-2362.