钟志远 - 苏州大学 - 材料与化学化工学部

个人简介

1974年2月生，江西赣州人。苏州大学特聘教授，国家杰出青年基金获得者，苏州大学生物医用高分子材料重点实验室主任，放射医学与辐射防护国家重点实验室靶向放射性药物创新与转化中心主任，荷兰Elsevier期刊J. Controlled Release（IF 7.9)亚洲区副主编,美国医学与生物工程院会士。1995年吉林工业大学（现吉林大学）获学士学位，1998年中国科学院长春应用化学研究所获硕士学位，2002年荷兰屯特大学获博士学位。2002-2007年荷兰屯特大学任助理教授。2007年4月起受聘为苏州大学特聘教授。2011-2012年担任苏州工业园区生物产业发展有限公司（苏州生物纳米园）副总裁

研究领域

生物医用高分子材料、药物控制释放、基因释放、生物组织工程、肿瘤靶向治疗

近期论文

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W.X. Gu, J.N. An, H. Meng, N. Yu, Y.N. Zhong, F.H. Meng*, Y. Xu*, J.L.M. Cornelissen, and Z.Y. Zhong*, CD44-Specific A6 Short Peptide Boosts Targetability and Anticancer Efficacy of Polymersomal Epirubicin to Orthotopic Human Multiple Myeloma, Adv. Mater. 2019, 1904742. Y. Yan, Y.Y. Dong, S.J. Yue, X.Y. Qiu, H.L. Sun*, and Z.Y. Zhong*, Dually Active Targeting Nanomedicines Based on a Direct Conjugate of Two Purely Natural Ligands for Potent Chemotherapy of Ovarian Tumor, ACS Appl. Mater. Interfaces 2019, 11, 46548-46557. H.L. Sun, X.L. Gu, Q. Zhang, H. Xu, Z.Y. Zhong*, and C. Deng*, Cancer Nanomedicines Based on Synthetic Polypeptides, Biomacromolecules 2019, 20, 4299-4311. L. Ding, W.X. Gu, Y.F. Zhang, S.J. Yue, H.L. Sun*, J. Cornelissen, and Z.Y. Zhong*, HER2-Specific Reduction-Sensitive Immunopolymersomes with High Loading of Epirubicin for Targeted Treatment of Ovarian Tumor, Biomacromolecules 2019, 20, 3855-3863. X.L. Gu, Z.H. Zhu, Y.H. Wei, G.L. Wang, F.H. Meng, Z.Y. Zhong*, and C. Deng*, Nano-Agents Based on Poly(ethylene glycol)-b-Poly(L-thyroxine) Block Copolypeptide for Enhanced Dual-Modality Imaging and Targeted Tumor Radiotherapy, Small 2019, 15, 1902577. Y. Zou, Y.H. Wei, J. Bao, F.R. Yao, Z.K. Li, Y.P. Sun, F.H. Meng*, C.H. Hu, G. Storm, and Z.Y. Zhong*, Cyclic RGD-Functionalized and Disulfide-Crosslinked Iodine-Rich Polymersomes as a Robust and Smart Theranostic Agent for Targeted CT Imaging and Chemotherapy of Melanoma, Theranostics 2019, 9, 8061-8072. M. Qiu, J. Ouyang, Y.H. Wei, J. Zhang, Q. Lan, C. Deng*, and Z.Y. Zhong*, Selective cell penetrating peptide-functionalized envelope-type chimaeric lipopepsomes boost systemic RNAi therapy for lung tumor, Adv. Healthcare Mater. 2019, 1900500. K. Huang, Y.H. He, Z.H. Zhu, J.K. Guo, G.L. Wang, C. Deng*, and Z.Y. Zhong*, Small, Traceable, Endosome-Disrupting and Bioresponsive Click Nanogels Fabricated via Microfluidics for CD44-Targeted Cytoplasmic Delivery of Therapeutic Proteins, ACS Appl. Mater. Interfaces 2019, 11, 22171-22180. J.S. Cao, Y.H. Wei, Y.X. Zhang, G.L. Wang*, X. Ji, and Z.Y. Zhong*, Iodine-rich polymersomes enable versatile SPECT/CT imaging and potent radioisotope therapy for tumor in vivo, ACS Appl. Mater. Interfaces 2019, 11, 18953-18959. Y.H. Wei, X.L. Gu, L. Cheng*, F.H. Meng*, G. Storm, and Z.Y. Zhong*, Low-toxicity Transferrin-Guided Polymersomal Doxorubicin for Potent Chemotherapy of Orthotopic Hepatocellular Carcinoma in Vivo, Acta Biomaterialia 2019, 92, 196-204. X.L. Gu, Y.H. Wei, Q.Y. Fan, H.L. Sun, R. Cheng, Z.Y. Zhong*, and C. Deng*, cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo, J. Control. Release 2019, 301, 110-118. Y. Jiang, J. Zhang*, F.H. Meng, and Z.Y. Zhong*, Apolipoprotein E Peptide-Directed Chimeric Polymersomes Mediate an Ultrahigh-Efficiency Targeted Protein Therapy for Glioblastoma, ACS Nano 2018, 12, 11070-11079. L. Cheng, Y. Yang, F.H. Meng*, Z.Y. Zhong*, Protein Nanotherapeutics as an Emerging Modality for Cancer Therapy, Adv. Healthcare Mater. 2018, 7, 1800685. Y.N. Shi, Y. Jiang, J.S. Cao, W.J. Yang, J. Zhang*, F.H. Meng, and Z.Y. Zhong*, Boosting RNAi therapy for orthotopic glioblastoma with nontoxic brain-targeting chimaeric polymersomes, J. Control. Release 2018, 292, 163-171. H.L. Sun, Y.F. Zhang, and Z.Y. Zhong*, Reduction-Sensitive Polymeric Nanomedicines: An Emerging Multifunctional Platform for Targeted Cancer Therapy, Adv. Drug Deliv. Rev. 2018, 132, 16-32. W.J. Yang, Y.H. Wei, J. Zhang, Z.Y. Zhong*, F.H. Meng*, Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo, J. Control. Release 2018, 290, 141-149. Y. Jiang, W.J. Yang, J. Zhang*, F.H. Meng, and Z.Y. Zhong*, Protein Toxin Chaperoned by LRP-1 Targeted Virus-Mimicking Vesicles Induces High-Efficiency Glioblastoma Therapy In Vivo, Adv. Mater. 2018, 30, 1800316. X.X. Wang, R. Cheng*, L. Cheng, and Z.Y. Zhong*, Lipoyl ester terminated star PLGA as a simple and smart material for controlled drug delivery application, Biomacromolecules 2018, 19, 1368-1373. Y.Q. Zhu, Y. Jiang, F.H. Meng, C. Deng, R. Cheng, J. Zhang*, J. Feijen*, and Z.Y. Zhong*, Highly efficacious and specific anti-glioma chemotherapy by smart tandem nanomicelles co-functionalized with brain tumor-targeting and cell-penetrating peptides, J. Control. Release 2018, 278, 1-8. Y.Q. Zhu, J. Feijen*, and Z.Y. Zhong*, Dual-Targeted Nanomedicines for Enhanced Tumor Treatment, Nano Today 2018, 18, 65-85.