Holland, Patrick - Yale University - Department of Chemistry

个人简介

Professional Positions Yale University Conkey P. Whitehead Professor of Chemistry (2021-) Professor of Chemistry (2013- ) University of Rochester Professor of Chemistry (2010-2013) Associate Professor of Chemistry (2005-2010) Assistant Professor of Chemistry (2000-2005) University of Minnesota (1997-2000) National Institutes of Health Postdoctoral Fellow Advisor: Prof. William B. Tolman Education University of California, Berkeley (1993-1997) Ph.D. in Chemistry, September 1997 Advisors: Profs. Robert G. Bergman and Richard A. Andersen Princeton University (1989-1993)A.B. magna cum laude (high honors) in Chemistry, June 1993 Awards Award for Excellence in Peer Reviewing, Petroleum Research Fund, 2021 Watkins Visiting Professor, Wichita State University, 2019 Xingda Lectureship, Peking University, 2017 Friedrich Wilhelm Bessel Research Award of the Humboldt Foundation, 2016 Fellow of the American Association for the Advancement of Science, 2015 Blavatnik Award for Young Scientists, 2013 Fulbright Scholar Award, 2012 ACS Rochester Section Volunteerism Award, 2010 Sloan Research Fellowship, 2003 NSF CAREER Award, 2002 NIH Postdoctoral Fellowship, University of Minnesota, 1997-1999 American Institute of Chemists Student Awardee, 1993 Phi Beta Kappa, Princeton University, 1993

研究领域

Our research focuses on developing new transformations of bonds in small molecules. We accomplish this using compounds containing metals, particularly iron. While we are interested in numerous bond making and breaking reactions, we have a particular interest in small molecules involved in energy research such as N2, H2, and CO2. This research develops students’ expertise in synthesis, spectroscopy, and catalysis. Please click the links below for information on different areas of research in the group. Low Coordinate Metals, and Redox-Active Ligands Metal-Ligand Multiple Bonds (not currently active) Engineered Proteins (not currently active) Nitrogenase and Nitrogen Activation (NSF, NIH, DOE funding) Organometallic Catalysis (NIH funding) Energy Research (DOE funding)

近期论文

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Sarah R. Buzsaki, Savannah M. Mason, Padmanabha V. Kattamuri, Juan M. I. Serviano, Dinora N. Rodriguez, Conner V. Wilson, Drew M. Hood, Jonathan D. Ellefsen, Yen-Chu Lu, Jolie Kan, Julian G. West, Scott J. Miller, Patrick L. Holland Fe/Thiol Cooperative HAT Olefin Hydrogenation: Mechanistic Insights that Inform Enantioselective Catalysis submitted , , . ChemRxiv Reagan X. Hooper, Ashlee E. Wertz, Hannah S. Shafaat, Patrick L. Holland Evaluating Diazene to N2 Interconversion at Iron-Sulfur Complexes Chem. Eur. J. 2024, 30, in press. Alexandra L. Nagelski, Mykhaylo Ozerov, Majed S. Fataftah, J. Krzystek, Samuel M. Greer, Patrick L. Holland, Joshua Telser Electronic Structure of Three-Coordinate FeII and CoII β-Diketiminate Complexes Inorg. Chem. 2024, 63, in press. Tong-De Tan, Juan M. I. Serviano, Xiaohua Luo, Peng-Cheng Qian, Patrick L. Holland, Xinglong Zhang, Ming Joo Koh Congested C(sp3)-rich architectures enabled by iron-catalysed conjunctive alkylation Nature Catal. 2024, 7, in press. Daniel W. N. Wilson, Majed S. Fataftah, Zachary Mathe, Brandon Q. Mercado, Serena DeBeer, Patrick L. Holland Three-Coordinate Nickel and Metal-Metal Interactions in a Heterometallic Iron-Sulfur Cluster J. Am. Chem. Soc. 2024, 146, 4013–4025. ChemRxiv Samuel M. Bhutto, Reagan X. Hooper, Sean F. McWilliams, Brandon Q. Mercado, Patrick L. Holland Iron(IV) alkyl complexes: electronic structure contributions to Fe–C bond homolysis and migration reactions that form N–C bonds from N2 Chem. Sci. 2024, 15, in press. Conner V. Wilson, Patrick L. Holland Mechanism of Alkene Hydrofunctionalization by Oxidative Cobalt(salen) Catalyzed Hydrogen Atom Transfer J. Am. Chem. Soc. 2024, 146, 2685–2700. Aleksandra Wandzilak, Katarzyna Grubel, Kazimer L. Skubi, Sean F. McWilliams, Dimitrios Bessas, Atanu Rana, Stefan Hugenbruch, Abhishek Dey, Patrick L. Holland, Serena DeBeer Mössbauer and Nuclear Resonance Vibrational Spectroscopy Studies of Iron Species Involved in N–N Bond Cleavage Inorg. Chem. 2023, 62, 18449–18464. Alexandre Genoux, Magnus Pauly, Conor L. Rooney, Chungseok Choi, Bo Shang, Scott McGuigan, Majed S. Fataftah, Yves Kayser, Simon C. B. Suhr, Serena DeBeer, Hailiang Wang, Paul A. Maggard, Patrick L. Holland Well-Defined Iron Sites in Crystalline Carbon Nitride J. Am. Chem. Soc. 2023, 145, 20739–20744. Majed S. Fataftah, Brandon Q. Mercado, Patrick L. Holland Valence delocalization in carbon-bridged mixed-valence iron complexes Chem. Eur. J. 2023, 29, e202301962. Reagan X. Hooper, Brandon Q. Mercado, Patrick L. Holland Desulfurization and N2 Binding at an Iron Complex Derived from C−S Activation of Benzothiophene Organometallics 2023, 42, 2019-2027. Samuel M. Bhutto, Brandon Q. Mercado, Patrick L. Holland Dinitrogen Binding and Functionalization from a Low-Coordinate Alkynyliron Complex Inorg. Chem. 2023, 62, 9335-9342. Alexandre T.-Y. Genoux, Stephen J. Tereniak, Patrick L. Holland Synthesis of new chelating phosphines containing an aryl chloride group Synthesis 2023, 55, 2737-2741. Juan M. I. Serviano, Erik J. T. Phipps, Patrick L. Holland Intermolecular Hydroalkoxylation and Hydrocarboxylation of 2-Azadienes with High Efficiency J. Org. Chem. 2023, 88, 3277-3281. Faraj Hasanayn, Patrick L. Holland, Alan S. Goldman, Alexander J. M. Miller Lewis Structures and the Bonding Classification of End-on Bridging Dinitrogen Transition Metal Complexes J. Am. Chem. Soc. 2023, 145, 4326-4342. Samuel M. Bhutto, Reagan X. Hooper, Brandon Q. Mercado, Patrick L. Holland Mechanism of Nitrogen-Carbon Bond Formation From Iron(IV) Disilylhydrazido Intermediates During N2 Reduction J. Am. Chem. Soc. 2023, 145, 4626-4637. Sean F. McWilliams, Brandon Q. Mercado, K. Cory MacLeod, Majed S. Fataftah, Maxime Tarrago, Xiaoping Wang, Eckhard Bill, Shengfa Ye, Patrick L. Holland Dynamic Effects on Ligand Field from Rapid Hydride Motion in an Iron(II) Dimer with an S=3 Ground State Chem. Sci. 2023, 14, 2303-2312. ORNL press release Sivathmeehan Yogendra, Daniel W. Wilson, Anselm Hahn, Thomas Weyhermüller, Casey Van Stappen, Patrick L. Holland, Serena DeBeer Sulfur-Ligated [2Fe-2C] Clusters as Synthetic Model Systems for Nitrogenase Inorg. Chem. 2023, 62, 2663-2671. Alexander S. Hegg, Brandon Q. Mercado, Alexander J. M. Miller, Patrick L. Holland Catalytic Reduction of Dinitrogen to Ammonia using Molybdenum Porphyrin Complexes Faraday Disc. 2023, 243, 429-449. Conner V. Wilson, Dongyoung Kim, Ajay Sharma, Reagan X. Hooper, Rinaldo Poli, Brian M. Hoffman, Patrick L. Holland Cobalt-Carbon Bonding in a Salen-Supported Cobalt(IV) Alkyl Complex Postulated in Oxidative MHAT Catalysis J. Am. Chem. Soc. 2022, 144, 10361-10367. Gannon P. Connor, Daniel Delony, Jeremy E. Weber, Brandon Q. Mercado, Julia B. Curley, Sven Schneider, James M. Mayer, Patrick L. Holland Facile conversion of ammonia to a nitride in a rhenium system that cleaves dinitrogen Chem. Sci. 2022, 13, 4010-4018. Kazimer L. Skubi, Reagan X. Hooper, Brandon Q. Mercado, Melissa M. Bollmeyer, Samantha N. MacMillan, Kyle M. Lancaster, Patrick L. Holland Iron Complexes of a Proton-Responsive SCS Pincer Ligand with a Sensitive Electronic Structure Inorg. Chem. 2022, 61, 1644-1658. Patrick L. Holland Introduction: Volume I Comprehensive Organometallic Chemistry IV 2022, Vol. 1, 1. Jeremy E. Weber, Samuel M. Bhutto, Alexandre T.-Y. Genoux, Patrick L. Holland Dinitrogen Binding and Functionalization Comprehensive Organometallic Chemistry IV 2022, Vol. 1, 521-554. Daniel W. N. Wilson, Patrick L. Holland Nitrogenases and model complexes in bioorganometallic chemistry Comprehensive Organometallic Chemistry IV 2022, Vol. 15, 41-72. Daniel Kim, Daniel W. N. Wilson, Majed S. Fataftah, Brandon Q. Mercado and Patrick L. Holland Spin states, bonding and magnetism in mixed valence iron(0)–iron(II) complexes Chem. Eur. J. 2022, 28, e202104431. Lynn S. Yamout, Mohamad Ataya, Faraj Hasanayn, Patrick L. Holland, Alexander J. M. Miller, Alan S. Goldman Understanding Terminal versus Bridging End-on N2 Coordination in Transition Metal Complexes J. Am. Chem. Soc. 2021, 143, 9744–9757. Jeremy E. Weber, Faraj Hasanayn, Majed S. Fataftah, Brandon Q. Mercado, Robert H. Crabtree, Patrick L. Holland Electronic and Spin-State Effects on Dinitrogen Splitting to Nitrides in a Rhenium Pincer System Inorg. Chem. 2021, 60, 6115-6124. Daniel J. DiPrimio, Patrick L. Holland Repurposing Metalloproteins as Mimics of Natural Metalloenzymes for Small-Molecule Activation J. Inorg. Biochem. 2021, 219, 111430. John W. Peters, Oliver Einsle, Dennis R. Dean, Serena DeBeer, Brian M. Hoffman, Patrick L. Holland, Lance C. Seefeldt Comment on “Structural evidence for a dynamic metallocofactor during N2 reduction by Mo-nitrogenase”Science 2021, 371, eabe5481. Daniel Kim, Guy Pillon, Daniel J. DiPrimio, Patrick L. Holland Highly Z-Selective Double Bond Transposition in Simple Alkenes and Allylarenes Through A Spin-Accelerated Allyl Mechanism J. Am. Chem. Soc. 2021, 143, 3070–3074. Amy L. Speelman, Kazimer L. Skubi, Brandon Q. Mercado, Patrick L. Holland Synthesis and Reactivity of Iron Complexes with a Biomimetic SCS Pincer Ligand Inorg. Chem. 2021, 60, 1965-1974. Sophia L. Shevick, Conner V. Wilson, Simona Kotesova, Dongyoung Kim, Patrick L. Holland, and Ryan Shenvi Catalytic hydrogen atom transfer to alkenes: a roadmap for metal hydrides and radicals Chem. Sci. 2020, 11, 12386-12400. Tenth anniversary issue Quinton J. Bruch, Gannon P. Connor, Noah D. McMillion, Alan S. Goldman, Faraj Hasanayn, Patrick L. Holland, Alexander J. M. Miller Considering Electrocatalytic Ammonia Synthesis via Bimetallic Dinitrogen Cleavage ACS Catal. 2020, 10, 10826–10846. Alexandra L. Nagelski, Majed S. Fataftah, Melissa M. Bollmeyer, Sean F. McWilliams, Samantha N. MacMillan, Brandon Q. Mercado, Kyle M. Lancaster, Patrick L. Holland The Influences of Carbon Donor Ligands on Biomimetic Multi-Iron Complexes for N2 Reduction Chem. Sci. 2020, 11, 12710-12720. Tenth anniversary issue Sean F. McWilliams, Daniel L. J. Broere, Connor J. V. Halliday, Samuel M. Bhutto, Brandon Q. Mercado, Patrick L. Holland Coupling Dinitrogen and Hydrocarbons through Aryl Migration Nature 2020, 584, 221-226. Chem. Eng. News "Research of the Year" Daniel Kim, Chi Chen, Brandon Q. Mercado, Daniel J. Weix, Patrick L. Holland Mechanistic Study of Alkene Hydrosilylation Catalyzed by a β-Dialdiminate Cobalt(I) Complex Organometallics 2020, 39, 2415-2424. Patrick L. Holland Introduction: Reactivity of Nitrogen from the Ground to the Atmosphere Chem. Rev. 2020, 120, 4919-4920. Guest Editor for Thematic Issue of Chemical Reviews Gal Hochman, Alan S. Goldman, Frank A. Felder, James M. Mayer, Alexander J. M. Miller, Patrick L. Holland, Leo A. Goldman, Patricia Manocha, Ze Song, Saketh Aleti The Potential Economic Feasibility of Direct Electrochemical Nitrogen Reduction as a Route to Ammonia ACS Sustainable Chem. Eng. 2020, 8, 8938-8948.