Hamilton, Andrew D. - Yale University - Department of Chemistry

研究领域

Organic Chemistry Biophysical Chemistry

近期论文

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Lockman, J. W.; Hamilton, A. D. "Recent Developments in the Identification of Chemotherapeutics for Chagas Disease" Curr. Med. Chem. 2005, 12, 945-959. Magliery, T. J.; Wilson, C. G. McD.; Pan, W.; Mischler, D.; Ghosh, I.; Hamilton, A. D.; Regan, L. "The scope and mechanism of the GFP fragment-reassembly protein-protein interaction trap" J. Am. Chem. Soc. 2005, 127, 146-157. Yin, H.; Lee, G.; Payne, G. A.; Rodriguez, J. M.; Sebti, S. M.; Hamilton, A. D. "Terphenyl-based Helical Mimetics that Disrupt the p53/HDM2 Interaction" Angew. Chemie Int. Ed. 2005, 44, 2704-2707. Carrico, D.; Blaskovich, M. A.; Bucher, C. J.; Sebti, S. M.; Hamilton, A. D. "Design, synthesis and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I", Bioorg. Med. Chem. Lett. 2005, 13, 677-688. Jain, R. K.; Tsou, L. K.; Hamilton, A. D. "Recognition of Cytochrome c by tetraphenylporphyrin-based Protein Surface Receptors" In Macrocyclic Chemistry: Current Trends and Future Perspectives, Gloe, K. Ed, Springer, 2005, 267-276. Hamilton, A. D.; Tagore, D. M.; Sprinz, K. I. "Formation and Recognition Properties of Dynamic Combinatorial Libraries" in Functional Synthetic Receptors, Schrader, T.; Hamilton, A. D. Eds. Wiley-VCH, Weinheim, 2005, 299-332. Woo, J. T.; Nakagawa, H.; Krecic, A. M.; Nagai K, Hamilton, A. D.; Sebti, S. M.; Stern, P. H. "Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha)" Biochem. Pharmacol. 2005, 69, 87-95. Yin, H.; Hamilton, A. D. "Protein Secondary Structure Mimetics as Modulators of Protein-protein and Protein-ligand Interactions" in First Reference of Chemical Biology , Schreiber, S.; Kapoor, T.; Wess, G. Eds. Wiley-VCH, WeinHeim, 2005. Estroff, L. A.; Hamilton, A. D "Cryo-TEM, X-Ray Diffraction and Modeling of an Organic Hydrogel in Gels", Weiss, R and Terech, P. Eds, In press. Zuckerbraun, B. S.; Barbato, J. E.; Hamilton, A. D.; Sebti, S. M.; Tzeng, E. "Geranylgeranyl Transferase Inhibition Decreases Generation Of Vascular Reactive Oxygen Species and Increases Vascular Nitric Oxide Production" J. Surgical Res. 2005, 124, 256-263. Sun, J.; Wang, D.; Jain, R.; Paquette, S.; Aya, T.; Blaskovich, M. A.; Baldini, L.; Coppola, D.; Hamilton, A. D.; Sebti, S. M. "Inhibiting Angiogenesis and Tumorigenesis by a Synthetic Molecule that Blocks the Binding of VEGF and PDGF to their Receptors" Oncogene, 2005, 24, 4701-4709. Nallan, L.; Bauer, K.; Bendale, P.; Rivas, K.; Yokoyama, K.; Pendyala, P. R.; Floyd, D.; Lombardo, L.; Williams, D. K.; Hamilton, A. D.; Sebti, S. M.; Windsor, W. T.; Weber, P. C.; Buckner, F. S.; Chakrabarti, D.; Gelb, M. H.; Van Voorhis, W. C. "Protein Farnesyltransferase Inhibitors Exhibit Potent Anti-Malarial Activity" J. Med. Chem. 2005, 48, 3704-3713. Tang, D., Park, H. J.; Sebti, S. M.; Hamilton, A. D.: Galper, J. B. "Statins potentiate TNFa mediated apoptosis in endothelial cells: Role of increased expression of TNFa Receptor I" Int. J. Cancer, Submitted. Lockman, J. W.; Ohkanda, J.; Eastman, R. T.; Yokoyama, K.; Buckner, F. S.; Van Voorhis, W. C.; Gelb, M. H.; Sebti, S. M.; Hamilton, A. D. "Development of Potent Sterol Biosynthesis Inhibitors Active Against Trypanosoma cruzi" J. Med. Chem. Submitted. Yin, H.; Lee G-I.; Hamilton, A. D. "Alpha-Helix Mimetics in Drug Discovery" in Drug Discovery Research in the Post Genomics Era, Huang, Z. Ed. John Wiley & Sons, New York, In Press. Yin, H.; Hamilton, A. D. "Strategies for Targeting Protein-Protein Interactions with Synthetic Agents", Angew. Chemie. Int. Ed. 2005, 44, 4130-4163. Zhu, K.; Gerbino, E.; Beaupre, D. M.; Mackley, P. A.; Muro-Cacho, C.; Hamilton, A. D.; Lichtenheld, M. G.; Dalton, W.; Alsina, M.; Sebti, S. M. "Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells" Blood, 2005, 105, 4759-4766. "Synthesis and Evaluation of Potent, Highly-selective, 3-Aryl-piperazinone Inhibitors of Protein Geranylgeranyltransferase-I", has been assigned to the following: Journal of Medicinal Chemistry Sprinz, K. I.; Tagore, D.; Hamilton, A. D. "Dynamic Libraries of Bivalent Protein-binding Agents based on Oligonucleotide-linked Organic Fragments" Bioorg. Med. Chem. Lett., 2005, 15, 3908-3911. Yin, H.; Lee, G.; Sedey, K. A.; Rodriguez, J. M.; Wang, H. G.; Sebti, S. M.; Hamilton, A. D. "Terephthalamide Derivatives as Mimetics of Helical Peptides: Disruption of the Bcl-xL/Bak Interaction" J. Am. Chem. Soc. 2005, 127, 5463-5468. Yin, H.; Lee, G.; Sedey, K. A.; Kutzki, O.; Park, H. S.; Orner, B. P.; Ernst, J. T.; Wang, H. G.; Sebti, S. M.; Hamilton, A. D. "Terphenyl-Based Bak-BH3 Alpha-Helical Proteomimetics as Low-Molecular-Weight Antagonists of Bcl-xL" J. Am. Chem. Soc. 2005, 127, 10191-10196. Glenn, M. P.; Chang, S. Y.; Hucke, O.; Verlinde, C. L. M. J.; Rivas, K.; Pickeral, C.; Yokoyama, K.; Buckner, F. S.; Pendyala, P. R.; Chakrabarti, D.; Gelb, M.; Van Voorhis, W. C.; Sebti, S. M.; Hamilton, A. D. "Structurally Simple Farnesyltransferase Inhibitors Arrest the Growth of Malaria Parasites" Angew. Chem. Int. Ed. 2005, 44, 4903-4906. Fan, X.; Potluri, V. K.; Mcleod, M. C.; Enick, R. M.; Hamilton, A. D.; Roberts, C. B.; Beckman, E. J. "Oxygenated Hydrocarbon Ionic Surfactants Exhibit CO2 solubility" J. Am. Chem. Soc. 2005, 127, 11754-11762. Zhou, H.; Baldini, L.; Hong, J.; Wilson, A. J.; Hamilton, A. D. "Pattern-Recognition of Proteins Based on an Array of Functionalized Porphyrins" J. Am. Chem. Soc. Submitted. Guida, W. C.; Hamilton, A. D.; Crotty, J. W.; Sebti, S. M. "Protein Farnesyltransferase: Flexible Docking Studies on Inhibitors Using Computational Modeling" J. Comp. Aided Mol. Design, In press. Ohkanda, J.; Strickland, C. L.; Blaskovich, M. A.; Carrico, D.; Lockman, J. W.; Vogt, A.; Bucher, C. J.; Sun, J.; Qian, Y.; Knowles, D.; Pusateri, E. E.; Sebti, S. M.; Hamilton, A. D. "Structure based design of imidazole containing peptidomimetic inhibitors of farnesyltransferase" Org. Biomol. Chem. Submitted. Chen, L.; Yin, H.; Farooqi, B.; Sebti, S.; Hamilton, A. D.; Chen, J. "p53 a-Helix Mimetics antagonize p53/MDM2 interaction and activate p53" Mol. Cancer Ther. 2005, 4, 1019-1025. Fletcher, S.; Hamilton, A. D. "Proteomimetics: Mimics of Protein Surface Structure and Function" Curr. Opin. Chem. Biol. Submitted. Zhou, H.; Hamilton, A. D. "Protein Surface Recognition" Encyclopedia of Supramolecular Chemistry, Atwood, J. Steed, J. Eds. Submitted. Jorgensen, W. J.; Ruiz-Caro, J.; Tirado-Rives, J.; Basavapathruni, A.; Anderson, K. S; Hamilton, A. D. "Computer-Aided Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase" Bioorg. Med. Chem. Lett. Submitted. Ruiz-Caro, J.; Basavapathruni, A.; Kim, J. T.; Bailey, C. M.; Wang, L.; Anderson, K. S; Hamilton, A. D.; Jorgensen, W. J. "Optimization of Diarylamines as Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase" Bioorg. Med. Chem. Lett. Submitted. Davis, J.; Truan, A.; Hamilton, A. D. "Synthesis of a 2,3'-Terpyridine Scaffold as an a-Helix Mimetic" Org. Lett. In press. Salvatella, X.; Martinell, M.; Gair, M.; Mateu, M.; Feliz, M.; Hamilton, A. D.; de Mendoza, J.; Giralt, E. "A Tetraguanidinium Ligand Binds the Surface of the Tetramerization Domain of Protein P53" Angew. Chem. Int. Ed. 2004, 43, 196-198. Estroff, L. A.; Addadi, L.; Weiner, S.; Hamilton, A. D. "An Organic Hydrogel as a Matrix for the Growth of Calcite Crystals" Org. Biomol. Chem. 2004, 2, 137-141. Estroff, L. A.; Incarvito, C. D.; Hamilton, A. D. "Design of a Synthetic Foldamer that Modifies that Growth of Calcite Crystals" J. Am. Chem. Soc. 2004, 126, 2-3. Baldini, L.; Wilson, A. J.; Hong, J.; Hamilton, A. D. "Pattern-Based Detection of Different Proteins using an Array of Fluorescent Protein Surface Receptors" J. Am. Chem. Soc. 2004, 126, 5656-5657. Turkson, J.; Kim, J. S.; Zhang, S.; Yuan, J.; Huang, M.; Haura, E.; Vultur, A. M.; Raptis, L.; Glenn, M.; Sebti, S. M.; Hamilton, A. D.; Jove, R. "Novel Proline-phosphotyrosyl-leucine peptidomimetic inhibitors of Stat3 signaling and biological activity" Mol. Cancer Therapeutics. 2004, 3, 261-269. Dan, H. C.; Jiang, K.; Coppola, D.; Jiang,, K.; Hamilton, A. D.; Nicosia, S. V.; Sebti, S. M.; Cheng, J. Q. "Phosphatidylinositol-3-OH Kinase/Akt and Survivin Pathways as Critical Targets for Geranylgeranyltransferase I Inhibitors Induced Apoptosis" Oncogene, In press. Estroff, L. A.; Hamilton, A. D. "Water Gelation by Small Organic Molecules" Chem. Rev. 2004, 104, 1201-1218. Ohkanda, J.; Buckner, F. S.; Lockman, J. W.; Yokoyama, K.; Carrico, D.; Eastman, R.; de Luca-Fradley, K.; Davies, W.; Croft, S. L.; Van Voorhis, W. C.; Gelb, M. H.; Sebti, S. M.; Hamilton, A. D. "Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti-Trypanosoma brucei Agents" J. Med. Chem. 2004, 47, 432-445. Jain, R.; Ernst, J.; Kutzki, O.; Park, Hamilton, A. D. "Protein Recognition using Synthetic Surface-Targeted Agents" J. Mol. Diversity, 2004, 89-100. Estroff, L. A.; Hamilton, A. D "Cryo-TEM, X-Ray Diffraction and Modeling of an Organic Hydrogel In Gels" Weiss, R and Terech, P. Eds, In press. Epling-Burnette, P. K.; Bai, F.; Wei, S.; Hamilton, A. D.; Painter, J. S.; Sebti, S. M.; Djeu, J. Y.; Loughran, T. P. "Constitutively activated ERK controls chronic survival in NK type of Lymphoproliferative Disease of Granular Lymphocytes (LDGL)" Oncogene. In press. Sun, J.; Blakovich, M. A.; Jain, R.; Paris, D.; Delarue, F.; Brem, S.; Wotocezk-Obadia, M.; Coppola, D.; Choi, K.; Mullan, M.; Hamilton, A. D.; Sebti, S. M. "Blocking Angiogenesis, tumorigenesis and metastasis with GFB-116, a Synthetic Agent that Disrupts Binding of VEGF to its Receptor" Cancer Research, 2004, 64, 3586-3592. Yin, H.; Hamilton, A. D. "Terephthalamide Derivatives as Mimetics of the Helical Region of Bak Peptide Target Bcl-xL Protein" Bioorg. Med. Chem. Lett. 2004, 14, 1375-1379. Tsou, L. K.; Jain, R. K.; Hamilton, A. D. "Protein surface recognition by porphyrin-based receptors" J. Porph. Phthalocyan. 2004, 8, 141-147. Carrico, D.; Ohkanda, J.; Kendrick, H.; Yokoyama, K.; Blaskovich, M. A.; Bucher, C. J.; Buckner, F. S.; Van Voorhis, W. C.; Croft, S. L.; Gelb, M. H.; Sebti, S. M.; Hamilton, A. D. �In vivo and in vitro activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability� Bioorg. Med. Chem. Lett. 2004, 12, 6517-6526. Epling-Burnette, P. K.; Bai, F.; Wei, S.; Hamilton, A. D.; Painter, J. S.; Sebti, S. M.; Djeu, J. Y.; Loughran, T. P. �Constitutively activated ERK controls chronic survival in NK type of Lymphoproliferative Disease of Granular Lymphocytes (LDGL), Oncogene. 2004, 23, 9220-9229.