Ellman, Jonathan A. - Yale University - Department of Chemistry

个人简介

Texaco Philanthropist Scholarship for excellence in chemistry, 1984 James Bryant Conant Scholarship Prize, 1984 National Science Foundation Predoctoral Fellowship, 1984 National Science Foundation Postdoctoral Fellowship, 1989 National Science Foundation Young Investigator Award, 1993 Arnold and Mabel Beckman Foundation Young Investigator Award, 1993 Burroughs Wellcome Fund Hitchings Award for Drug Design and Discovery, 1993 Office of Naval Research Young Investigator Award, 1994 Alfred P. Sloan Fellowship, 1994 Eli Lilly Grantee Award, 1994 Cyanamid Faculty Award, 1994 Procter and Gamble Young Investigator, 1994 Joel H. Hildebrand Associate Professor Chair in Chemistry (UC Berkeley), 1996 Burroughs Wellcome Fund New Initiatives in Malaria Research Award, 1997 Department of Chemistry Teaching Award (UC Berkeley), 1998 American Chemical Society Arthur C. Cope Scholar Award, 2000 Society of Biomolecular Screening Achievement Award, 2003 Scheele Award selected by the Swedish Academy of Pharmaceutical Sciences, 2003 Tetrahedron Young Investigator Award in Bioorganic and Medicinal Chemistry, 2006 Fellow of the American Association for the Advancement of Science, 2006 GlaxoSmithKline Chemistry Scholar Award, 2010 Royal Society of Chemistry Pedler Award, 2010 American Chemical Society Herbert C. Brown Award for Creative Research in Synthetic Methods, 2012

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Jamali, H.; Khan, H. A.; Stringer, J. A.; Chowdhury, S. Ellman, J. A. Identification of Multiple Structurally-Distinct, Nonpeptidic Small Molecule Inhibitors of Protein Arginine Deiminase 3 Using a Substrate-Based Fragment Method J. Am. Chem. Soc. 2015, ASAP, . Otley, K. D.; Ellman, J. A. An Efficient Method for the Preparation of Styrene Derivatives via Rh(III)-Catalyzed Direct C–H Vinylation Org. Lett. 2015, 17, 1332–1335. Matsushima, Y.; Phillips, E. M.; Bergman, R. G.; Ellman, J. A. Rh(I)-Catalyzed Cycloisomerization of 1,6-Enynes Synlett 2015, eFirst, . Baguley, T. D.; Nairn, A. C.; Lombroso, P. J.; Ellman, J. A. Synthesis of Benzopentathiepin Analogs and Their Evaluation as Inhibitors of the Phosphatase STEP Bioorg. Med. Chem. Lett. 2015, 25, 1050-1052. Hummel, J. R.; Ellman, J. A. Cobalt(III)-Catalyzed Synthesis of Indazoles and Furans by C–H Bond Functionalization/Addition/Cyclization Cascades J. Am. Chem. Soc. 2015, 137, 490–498. Otley, K. D.; Ellman, J. A. A Lewis Acid-Catalyzed Annulation to 2,1-Benzisoxazoles J. Org. Chem. 2014, 79, 8296–8303. Mesganaw, T.; Ellman, J. A. Convergent Synthesis of Diverse Tetrahydropyridines via Rh(I)-Catalyzed C–H Functionalization Sequences Org. Process Res. Dev. 2014, 18, 1097–1104. Mesganaw, T.; Ellman, J. A. Preparative Synthesis of Highly Substituted Tetrahydropyridines via a Rh(I)-Catalyzed C–H Functionalization Sequence Org. Process Res. Dev. 2014, 18, 1105–1109. Phelan, J. P.; Patel, E. J.; Ellman, J. A. Catalytic Enantioselective Addition of Thioacids to Trisubstituted Nitroalkenes Angew. Chem. Int. Ed. 2014, 53, 11329–11332. Xu, J.; Chatterjee, M.; Baguley, T. D.; Brouillette, J.; Kurup, P.; Ghosh, D.; Kanyo, J.; Zhang, Y.; Seyb, K.; Ononenyi, C.; Foscue, E.;Cuny, G. D.; Glicksman, M. A.; Greengard, P.; Lam, T. T.; Tautz, L.; Nairn, A. C.; Ellman, J. A.; Lombroso, P. A. Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer’s Disease PLoS Biol. 2014, 12, e1001923. Wangweerawong, A.; Bergman, R. G.; Ellman, J. A. Asymmetric Synthesis of α-Branched Amines via Rh(III)-Catalyzed C–H Bond Functionalization J. Am. Chem. Soc. 2014, 136, 8520–8523. Duttwyler, S.; Chen, S.; Lu, C.; Mercado, B. Q.; Bergman, R. G.; Ellman, J. A. Regio- and Stereoselective 1,2-Dihydropyridine Alkylation/Addition Sequence for the Synthesis of Piperidines with Quaternary Centers Angew. Chem. Int. Ed. 2014, 53, 3877–3880. Buesking, A. W.; Bacauanu, V.; Cai, I.; Ellman, J. A. Asymmetric Synthesis of Protected α-Amino Boronic Acid Derivatives with an Air- and Moisture-Stable Cu(II) Catalyst J. Org. Chem. 2014, 79, 3671–3677. Buesking, A. W.; Ellman, J. A. Convergent, Asymmetric Synthesis of Vicinal Amino Alcohols via Rh-Catalyzed Addition of α-Amido Trifluoroborates to Carbonyls Chem. Sci. 2014, 5, 1983-1987. Baguley, T. D.; Xu, H.-C.; Chatterjee, M.; Nairn, A. C.; Lombroso, P. J.; Ellman, J. A. Substrate-Based Fragment Identification for the Development of Selective, Nonpeptidic Inhibitors of Striatal-Enriched Protein Tyrosine Phophatase J. Med. Chem. 2013, 56, 7636-7650. Xu, H. C.; Chowdhury, S.; Ellman, J. A. Asymmetric Synthesis of Amines Using tert-Butanesulfinamide Nat. Protoc. 2013, 8, 2271-2280. Khan, H. A.; Ellman, J. A. Asymmetric Synthesis of α-Aminophosphonate Esters by the Addition of Dialkyl Phosphites to tert-Butanesulfinyl Imines Synthesis 2013, 45, 3147–3150. Lian, Y.; Hummel, J. R.; Bergman, R. G.; Ellman, J. A. Facile Synthesis of Unsymmetrical Acridines and Phenazines by a Rhodium(III)-Catalyzed Amination, Cyclization and Aromatization Cascade J. Am. Chem. Soc. 2013, 135, 12548-12551. Lian, Y.; Bergman, R. G.; Lavis, L. D.; Ellman, J. A. Rhodium(III)-Catalyzed Indazole Synthesis by C-H Bond Functionalization and Cyclative Capture J. Am. Chem. Soc. 2013, 135, 7122-7125. Brasse, M.; Cámpora, J.; Begman, R. G.; Ellman, J. A. Mechanistic Study of the Oxidative Coupling of Styrene with 2-Phenylpyridine Derivatives Catalyzed by Cationic Rhodium(III) via C–H Activation J. Am. Chem. Soc. 2013, 135, 6427-6430. Ischay, M. A.; Takase, M. K.; Bergman, R. G.; Ellman, J. A. Unstabilized Azomethine Ylides for the Stereoselective synthesis of Substituted Piperidines, Tropanes and Azabicyclo[3.1.0] systems J. Am. Chem. Soc. 2013, 135, 2478-2481.

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