Crews, Craig - Yale University - Department of Chemistry

个人简介

Burroughs Wellcome Young Investigator, 1996-99 Fellow of the Royal Society of Chemistry 2005 Bessel Research Award, Alexander von Humboldt Foundation, 2006 Editor, Chemistry&Biology, 2008

研究领域

Organic Chemistry/Bioorganic Chemistry/Chemical Biology

近期论文

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Highly Efficient Targeted Mutagenesis in the Axolotl using Cas9 RNA-guided Nuclease. Flowers GP, Timberlake AT, Mclean KC, Monaghan JR, Crews CM Development 2014 (): Small Molecule Control of Intracellular Protein Levels through Modulation of the Ubiquitin Proteasome System. Buckley DL, and Crews CM Angewandte Chem. Int. Ed. 2014 53(9):2312-2330 A Bidirectional System for the Dynamic Small Molecule Control of Intracellular Fusion Proteins. Neklesa TK, Noblin DJ, Kuzin A, Lew S, Seetharaman J, Acton TB, Kornhaber G, Xiao R, Montelione GT, Tong L, Crews CM. ACS Chemical Biology 2013 8(10):2293-2300 From epoxomicin to carfilzomib:chemistry, biology, and medical outcomes. Kim KB, Crews CM Natural Product Reports 2013 30(5):600-604 Posttranslational Protein Knockdown Coupled to Receptor Tyrosine Kinase Activation with PhosphoPROTACs. Hines J, Grough JD, Corson TW, Crews C Proc Natl Acad Sci U.S.A. 2013 110(22):8942-8947 A HaloTag-based Small Molecule Microarray Screening Methodology with Increased Sensitivity and Multiplex Capabilities Noblin DJ, Page CM, Tae HS, Gareiss PC, Schneekloth JS, Crews CM ACS Chemical Biology 2012 7(12):2055-2063 Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α Buckley DL, Gustafson JL, Van Molle I, Roth AG, Tae HS, Gareiss PC, Jorgensen WL, Ciulli A, Crews CM Angew. Chem. Int. 2012 51(46):11463-11467 Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau protein:Hypoxia Inducible Factor 1α Protein-Protein Interface Van Molle I, Thomann A, Buckley DL, So EC, Lang S, Crews CM, Ciulli A Chemistry & Biology 2012 19():1300-1312 Greasy tags for protein removal. Neklesa TK, Crews CM Nature 2012 487(19):308-309 Targeting the von Hippel-Lindau E3 Ubiquitin Ligase using Small Molecules to Disrupt the VHL-HIF-1alpha Interaction. Buckley DL, Van Molle I, Gareiss PC, Tae H-S, Miche J, Noblin DJ, Jorgensen WL, Ciulli A, Crews CM J. Am. Chem. Soc 2012 134(10):4465-4468 Microarray Analysis of microRNA Expression during Axolotl Limb Regeneration Holman EC, Campbell LJ, Hines J, Crews CM PLOS|One 2012 7(9):1-10 Identification of Hydrophobic Tags for Degradation of Stabilized Proteins. Tae H-S, Sundberg TB, Neklesa TK, Noblin DJ, Gustafson JL, Roth AG, Raina K, Crews CM ChemBioChem 2012 13(4):538-541 Gene expression profile of the regeneration epithelium during axolotl limb regeneration. Campbell LJ, Suárez-Castillo EC, Ortiz-Zuazaga H, Knapp D, Tanaka EM, Crews CM Dev Dyn 2011 240(7):1826-1840 A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Fedeles SV, Tian X, Gallagher AR, Mitobe M, Nishio S, Lee SH, Cai Y, Geng L, Crews CM, Somlo S Nat Genet 2011 43(7):639-647 Proteasome Inhibitors. Kauffman MG, Molineaux CJ, Kirk CJ, Crews CM Cancer: Principles & Practice of Oncology (Eds., Devita VT, Lawrence TS, Rosenberg SA, DePinho RA) 2011 Chapter 41():441-449 Disruption of Wnt Planar Cell Polarity Signaling by Aberrant Accumulation of the MetAP-2 Substrate Rab37. Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Clusarski DC, Beynon RJ, Crews CM Chemistry & Biology 2011 18(10):1300-1311 Triptolide Directly Inhibits dCTP pyrophosphatase. Corson TW, Cavga H, Aberle N, Crews CM ChemBioChem 2011 12(11):1767-1773 Small-molecule hydrophobic tagging-induced degradation of HaloTag Fusion proteins. Neklesa TK, Tae HS, Schneekloth AR, Stulberg MJ, Corson TW, Sundberg TB, Raina K, Holley SA, Crews CM Nat Chem Biol 2011 7(8):538-43 Unexpected stereochemical tolerance for the biological activity of tyroscherin. Tae HS, Hines J, Schneekloth AR, Crews CM Bioorg Med Chem 2011 19(5):1708-1713 HIV protease-mediated activation of sterically capped proteasome inhibitors and substrates. Buckley DL, Corson TW, Aberle N, Crews CM J Am Chem Soc 2011 133(4):698-700