Crawford, Jason M. - Yale University - Department of Chemistry

个人简介

Sarah and Adolph Roseman Achievement Award, 2007 Damon Runyon Cancer Research Foundation Postdoctoral Fellowship, 2009-2011 National Institutes of Health Pathway to Independence Award, 2011 Member, Yale Chemical Biology Institute, 2012-present Damon Runyon Cancer Research Foundation Dale F. Frey Award for Breakthrough Scientists, 2012 Searle Scholoars Award, 2013 National Institutes of Health New Innovator Award, 2013 Member, Faculty of 1000, Chemical Biology, Small Molecule Chemistry section, 2013-present

研究领域

Chemical Biology/Organic Chemistry/Biophysical Chemistry

近期论文

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Engel, P.,† Vizcaino, M.I., Crawford, J.M. 2014. Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthetic pathways. Appl. Environ. Microbiol. Pubmed Link Guo, X., Crawford, J.M.† 2014. An atypical carbohydrate-NRPS genomic island encodes a novel lytic transglycosylase. Chem. Biol. 21(10):1271-7. Pubmed Link Research in the News: Shelton, J. 2014. Setting a course for genomic islands. YaleNews. September 15. Vizcaino, M.I., Engel, P., Trautman, E., Crawford, J.M.† 2014. Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules. J. Am. Chem. Soc. 136(26):9244-7. Pubmed Link Vizcaino, M.I., Guo, X., Crawford, J.M.† 2014. Merging chemical ecology with bacterial genome mining for secondary metabolite discovery. J. Ind. Microbiol. Biotechnol. 41(2):285-99. Pubmed Link Vagstad, A.L., Newman, A.G., Storm, P.A., Belecki, K., Crawford, J.M., Townsend, C.A.† 2013. Combinatorial Domain Swaps Provide Insights into the Rules of Fungal Polyketide Synthase Programming and the Rational Synthesis of Non-Native Aromatic Products. Angew. Chem. Int. Ed. 52(6):1718-21. Pubmed Link Somvanshi, V.S., Sloup, R.E., Crawford, J.M., Martin, A.R., Heidt, A.J., Kim, K.-S., Clardy, J., Ciche, T.A.† 2012. A Single Promoter Inversion Switches Photorhabdus Between Pathogenic and Mutualistic States. Science. 337: 88-93. Pubmed Link Crawford, J.M.*, Portmann, C.*, Zhang, X., Roeffaers, M.B.J., and Clardy, J.† 2012. Small molecule perimeter defense in entomopathogenic bacteria. Proc. Natl. Acad. Sci. USA. 109 (27): 10821-10826. Pubmed Link Crawford, J.M. and Clardy, J.† 2012. Microbial genome mining answers longstanding biosynthetic questions. Proc. Natl. Acad. Sci. USA. 109 (20): 7589-90. Pubmed Link Crawford, J.M., Portmann, C., Kontnik, R. Walsh, C.T., and Clardy, J.† 2011. NRPS substrate promiscuity diversifies the xenematides. Org. Lett. 13 (19): 5144-5147. Pubmed Link Crawford, J.M.*, Mahlstedt, S.A.*, Malcolmson, S.J., Clardy, J., and Walsh, C.T.† 2011. Dihydrophenylalanine: A prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis. Chem. Biol. 18: 1102-1112. Crawford, J.M. and Clardy, J.† 2011. Bacterial symbionts and natural products. Chem. Commun. 47: 7559-7566. Pubmed Link Crawford, J.M. and Townsend, C.A.† 2010. New insights into the formation of fungal aromatic polyketides. Nature Rev. Micro. 8 (12): 879-889. Crawford, J.M. and Clardy, J.† 2010. Biosynthesis: Not just passing through. Nature Chem. 2: 805-807. Pubmed Link Kontnik, R.*, Crawford, J.M.*, and Clardy, J.† 2010. Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens. ACS Chem. Biol. 5 (7): 659-665. D’Onofrio, A.*, Crawford, J.M.*, Stewart, E.J., Witt, K. Gavrish, E. Epstein, S., Clardy, J.†, and Lewis, K.† 2010. Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem. Biol. 17: 254-264. Ehrlich, K.C.*†, Chang, P.-K.*, Scharfenstein, L., Cary, J.W., Crawford, J.M., and Townsend, C.A. 2010. Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Aspergillus flavus cultures. FEMS Microbiol. Lett. 305: 65-70. Korman, T.P.*, Crawford, J.M.*, Labonte, J., Wong, J. Townsend, C.A.†, and Tsai, S.-C.† 2010. Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proc. Natl. Acad. Sci. USA. 107: 6246-6251. Crawford, J.M.*, Kontnik, R.*, and Clardy, J.† 2010. Regulating alternative lifestyles in entomopathogenic bacteria. Current Biology. 20: 69-74. Crawford, J.M*, Korman, T.P.*, Labonte, J.W., Vagstad, A.L., Hill, E.A., Kamari-Bidkorpeh, O., Tsai, S.-C.†, and Townsend, C.A.† 2009. Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature. 461: 1139-1143. Belecki, K., Crawford, J.M., and Townsend, C.A.† 2009. Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures. J. Am. Chem. Soc. 131: 12564-12566.