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研究领域

(1) 化学生物学:荧光探针的设计、合成及在生命体内的应用研究 (2) 有机化学:具有生理活性的有机小分子的合成及性质研究

近期论文

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Liao, Y.-X. Li, K.*, Wu, M.-Y.; Wu, T.; Yu, X.-Q.* A selenium-contained aggregation-induced “turnon” fluorescent probe for hydrogen peroxide Org. Biomol. Chem. 2014, DOI: 10.1039/c4ob00206g He, T.; Li, K.*; Wang, N.; Liao, Y.-X.; Wang, X.; Yu X.-Q * A ferrocene-based multiple- stimuli responsive organometallogel. Soft Matter. 2014, DOI: 10.1039/c3sm53141d He, T.; Li, K.*; Wu, M.Y.; Liao, Y.-X. and Yu, X.-Q.* Visual detection of amino acids by supramolecular gel collapse. RSC Adv., 2014, 4, 2119-2123. Wu, M.-Y.; Li, K.*; Li, C.-Y.; Hou, J.-T.; Yu, X.-Q.* A Water-Soluble Near-Infrared Probe for Colorimetric and Ratiometric Sensing of SO2 Derivatives in Living Cells. Chem. Commun. 2014,50, 183-185. Hou, J.-T.; Li, K.* Yu, K.-K.; Ao, M.-Z.; Wang, X.; Yu, X.-Q.* Novel triazole-based fluorescent probes for Pd2+ in aqueous solutions: design, theoretical calculations and Imaging. Analyst, 2013, 138, 6632–6638 Wu, M.-Y.; He, T.; Li, K.*; Wu, M.-B.; Huang, Z.; Xie, Y.-M.*; Yu, X.-Q.* “A real-time colorimetric and ratiometric fluorescent probe for sulfite” Analyst 2013, 138(10), 3018-3025. Xu, H.-R.; Li, K.*; Liu, Q.; Wu, T.-M.; Wang, M.-Q.; Hou, J.-T.; Huang, Z.; Xie, Y.-M.*; Yu, X.-Q.* “Dianthracene-cyclen conjugate: the first equal-equivalent responding fluorescent chemosensor for Pb2+ in aqueous solution” Analyst 2013, 138(8), 2329-2334. Hou, J.-T.; Li, K.*; Yu, K.-K.; Wu, M.-Y.; Yu, X.-Q.* “Coumarin-DPA-Cu(II) as a chemosensing ensemble towards histidine determination in urine and serum” Org. Biomol. Chem. 2013, 11(5), 717-720. Hou, J.-T.; Liu, B.-Y. ; Li K.* ; Yu K.-K.; Wu, M.-B.; Yu, X.-Q.* Two birds with one stone: Multifunctional and highly selective fluorescent probe for distinguishing Zn2+ from Cd2+ and selective recognition of sulfide anion. Talanta, 2013,116, 434–440. Jiao, S.-Y.; Peng, L.-L.; Li, K.*; Xie, Y.-M.; Ao, M.-Z.; Wang, X.*; Yu, X.-Q.* A BINOL-based ratiometric fluorescent sensor for Zn2+ and in situ generated ensemble for selective recognition of histidine in aqueous solution. Analyst, 2013, 138, 5762-5768. He, T.; Li, K.*; Wu, M.-Y.; Wu, M.-B.; Wang, N.; Pu, L.; Yu, X.-Q.* “Water promoted enantioselective aldol Reaction by proline-cholesterol and -diosgenin based amphiphilic organocatalysts” Tetrahedron 2013, 69(25), 5136-5143. Li, K.; Xu, H.-R.; Yu, K.-K.; Hou, J.-T.; Yu, X.-Q.* “A coumarin-based chromogenic and ratiometric probe for hydrazine” Anal. Methods 2013, 5, 2653-2656. Hou, J.-T.; Li, K.*; Liu, B.-Y.; Liao, Y.-X.; Yu, X.-Q.* “The first ratiometric probe for lysine in water” Tetrahedron 2013, 69(9), 2118-2123. Wang, M.-Q.; Li K.*; Xu, H.-R.; Yu X.-Q.* Imidazolium-based 1,1′-bi-2-naphthol fluorescent probe for ratiometric and selective detection of DNA in water. Anal. Methods 2013, 5, 5903-5907 Yu, K.-K.; Li, K.*; Hou, J.-T.; Yu, X.-Q.* Coumarin–TPA derivative: a reaction-based ratiometric fluorescent probe for Cu(I). Tetrahedron Lett. 2013, 54, 5771–5774 Wang, M.-Q.; Li K.*; Hou J.-T.; Wu, M.-Y., Huang, Z.; Yu X.-Q.* “BINOL-Based Fluorescent Sensor for Recognition of Cu(II) and Sulfide Anion in Water” J. Org. Chem. 2012, 77, 8350−8354. Wu, M.-Y., Li, K.*; Hou, J.-T.; Huang, Z.; Yu, X.-Q.* “A selective colorimetric and ratiometric fluorescent probe for hydrogen sulfide” Org. Biomol. Chem. 2012, 10, 8342-8347. Wu, M.-Y.; Li K.*; Wang, N.; He T.; Yu X.-Q.* A Novel Catalyst-Free Tandem Reaction for the Synthesis of 5-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones in Water Medium (feature article). Synthesis 2011, 12, 1831-1839. Wu, M.-Y.; Wang, M.-Q.; Li K.*; Feng, X.-W.; He T.; Wang N.; Yu X.-Q.*, An Efficient, Transition-Metal-Free Process for the Synthesis of Substituted Dihydrofurans via a Michael/Cyclization Tandem Reaction. Tetrahedron Lett. 2011, 52, 679-683. Wu, M.-Y.; Li, K.*; He, T.; Feng, X.-W.; Wang, N.; Wang, X.-Y.; Yu X.-Q.*, A Novel Enzymatic Tandem Process: Utilization of Biocatalytic Promiscuity for High Stereoselective Synthesis of Hydroxyimino-Substituted Dihydrofurans Derivatives. Tetrahedron 2011, 67, 2681-2688. He, T., Li, K.*; Wu, M.-Y.; Feng, X.-W.; Wang, N., Wang, H.-Y.; Li, C.; Yu X.-Q.* Utilization of biocatalytic promiscuity for lipase-catalyzed direct Mannich reaction. J. Mol. Catal. B: Enzym. 2010, 67, 189-194. Chen, X.; Huang, Z.; Chen, S.-Y.; Li, K.; Yu X.-Q.*; Pu, L.*, Enantioselective Gel Collapsing: A New Means of Visual Chiral Sensing. J. Am. Chem. Soc. 2010, 132, 7297–7299. Liu, P.-Y.; Li, K.*; Zhang, J.; Zhang, D.-W.; Lin, H.-H.; Yu X.-Q.*, Who is the king? ‘β-OH-acraldehyde or catechol B ring’: Research on the relationship between the structure of quercetin derivatives and their pro-oxidative abilities. Chem. Biodiv. 2010, 7, 236-244. Li, K.; He T.; Li, C.; Feng, X.-W., Wang, N.; Yu X.-Q.*, Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity to C-C bond formation in a “one-pot” synthesis. Green Chem. 2009, 11, 777-779. Li, K.; Zhang, J.; Zhang, Z.-W.; Xiang, Y.-Z.; Lin, H.-H.; Yu X.-Q.*, Immobilization Cyclen Copper (II) on Merrifield Resin:Efficient Oxidative Cleavage of Plasmid DNA. J. Appl. Polym. Sci. 2009, 111. 2485–2492. Li, K.; Zhou, L.-H.; Zhang, J.; Chen, S.-Y.; Zhang, Z.-W.; Zhang, J.-J.; Lin, H.-H.; Yu X.-Q.*, ‘‘Self-activating’’ chemical nuclease: Ferrocenyl cyclen Cu(II) complexes act as efficient DNA cleavage reagents in the absence of reductant. Eur. J. Med. Chem. 2009, 44, 1768-1772. Li, K.; Wang, N.; Yang, F.; Zhang, Z.-W.; Zhou, L.-H.; Chen, S.-Y; Lin, H.-H; Tian, Y.-F.; Yu, X.-Q.*, Cyclen-based side-chain homopolymer self-assembly with plasmid DNA: Protection of DNA from enzymatic degradation. Chem. Biodiv. 2009, 6, 754-763. Feng, X.-W.; Li, C.; Wang, N., Li, K.; Zhang, W.-W.; Wang, Z.; Yu X.-Q.*, Lipase-catalysed decarboxylative aldol reaction and decarboxylative Knoevenagel reaction, Green Chem., 2009, 11, 1933-1936."

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