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研究领域

生物材料:新型核酸和药物传输系统的设计、合成和建立,基因载体/药物载体的构效关系研究; 有机合成化学:高效、高选择性的绿色合成方法学的研究,微波促进的有机反应方法学研究。

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Yi, W.-J.; Yu, X.-C.; Wang, B.; Zhang, J.*; Yu, Q.-Y.; Zhou, X.-D.; Yu, X.-Q.* “TACN-based oilgomers with aromatic backbones for efficient nucleic acid delivery” Chem. Commun. 2014, DOI: 10.1039/C4CC01210K. Zhang, Q.-F.; Yi, W.-J.; Wang, B.; Zhang, J.*; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q.* “Linear polycations by ring-opening polymerization as non-viral gene delivery vectors: structure-activity relationship studies” Biomaterials 2013, 34(21), 5391-5401. Yi, W.-J.; Zhang, Q.-F.; Zhang, J.*; Liu, Q.; Ren, L.; Chen, Q.-M.; Guo, L.; Yu, X.-Q.* “Cyclen-based lipidic oligomers as potential gene delivery vehicles” Acta Biomater. 2014, 10(4), 1412-1422. Liu, B.-Q.; Yi, W.-J.; Zhang, J.*; Liu, Q.; Liu, Y.-H.; Fan, S.-D.; Yu, X.-Q.* “Synthesis and gene transfection activity of cyclen-based cationic lipids with asymmetric acyl–cholesteryl hydrophobic tails” Org. Biomol. Chem. 2014, DOI: 10.1039/C4OB00384E. Xun, M.-M.; Liu, Y.-H.; Guo, Q.; Zhang, J.*; Zhang, Q.-F.; Wu, W.-X.; Yu, X.-Q.* “Low molecular weight PEI-appended polyesters as non-viral gene delivery vectors” Eur. J. Med. Chem. 2014, 78, 118-125. Wang, B.; Yi, W.-J.; Zhang, J.*; Zhang, Q.-F.; Xun, M.-M.; Yu, X.-Q.* “TACN-based cationic lipids with amino acid backbone and double tails: Materials for non-viral gene delivery” Bioorg. Med. Chem. Lett. 2014, 24(7), 1771-1775. Zhang, Y.; Li, C.-Y.; Zhang, J.*; Yi, W.-J.; Yu, X.-Q.* “Small cyclen-imidazolium-containing molecules and their interactions with DNA” Chem. Biodiver. 2014, 11(2), 233-244. Xun, M.-M.; Zhang, X.-C.; Zhang, J.*; Jiang, Q.-Q.; Yi, W.-J.; Zhu, W.; Yu, X.-Q.* “Low molecular weight PEI-based biodegradable lipopolymers as gene delivery vectors” Org. Biomol. Chem. 2013, 11(7), 1242-1250. Liu, Q.; Jiang, Q.-Q.; Yi, W.-J.; Zhang, J.*; Zhang, X.-C.; Zhang, Y.-M.; Zhu, W.; Yu, X.-Q.* “Novel imidazole-functionalized cyclen cationic lipids: synthesis and application as non-viral gene vectors” Bioorg. Med. Chem. 2013, 21(11), 3105-3113. Liu, Q.; Yi, W.-J.; Zhang, Y.-M.; Zhang, J.*; Guo, L.-D.; Yu, X.-Q.* “Biotinylated cyclen-contained cationic lipids as non-viral gene delivery vectors” Chem. Biol. Drug Des. 2013, 82(4), 376-383. Feng, J.; Yang, X.-B.; Liang, S.; Zhang, J.*; Yu, X.-Q.* “An Efficient Oxidative Coupling Method for Synthesis of Novel Diastereomeric Biaryl Diols Derived from Estrone” Tetrahedron Lett. 2013, 54(4), 355-357. Lu, Q.; Hou, J.; Wang, J.; Xu, B.; Zhang, J.*; Yu, X.-Q.* “Multichannel Chromogenic and Chiral Anions Recognition by Imidazolium Functionalized BINOL Derivatives”Chin. J. Chem. 2013, 31(5), 641-650. Wang, J.; Wang, S.; Wang, G.; Zhang, J.*; Yu, X.-Q.* “Iron-Mediated Direct Arylation with Arylboronic Acids through an Aryl Radical Transfer Pathway” Chem. Commun. 2012, 48(96), 11769-11771. Feng, J.; Liang, S.; Chen, S.-Y.; Zhang, J.*; Fu, S.-S.; Yu, X.-Q.* “A Metal-Free Oxidative Esterification of Benzyl C-H Bond” Adv. Synth. Catal. 2012, 354(7), 1287-1292. Huang, Q.-D.; Ren, J.; Chen, H.; Ou, W.-J.; Fu, Y.; Zhang, J.*; Zhu, W.; Yu, X.-Q.* “Cyclen based-cationic lipids containing carbamate linkages as efficient gene delivery vector with low toxicity” ChemPlusChem 2012, 77(7), 584-591. Wen, J.; Zhang, R.-Y.; Chen, S.-Y.; Zhang, J.*; Yu, X.-Q.* “Transition Metal-Free Direct Arylation of Arene and N-Heteroarenes with Diaryliodonium Salts” J. Org. Chem. 2012, 77(1), 766-771. Li, S.; Wang, Y.; Wang, S.; Zhang, J.*; Wu, S.-F.; Wang, B.-L.; Zhu, W.; Yu, X.-Q.* “Biodegradable cyclen-based linear and cross-linked polymers as non-viral gene vectors” Bioorg. Med. Chem. 2012, 20(4), 1380-1387. Huang, Q.-D.; Ren, J.; Ou, W.-J.; Fu, Y.; Cai, M.-Q.; Zhang, J.*; Zhu, W.; Yu, X.-Q.* “Cationic lipids containing cyclen and ammonium moieties as gene delivery vectors” Chem. Biol. Drug Des. 2012, 79(6), 879-887. Wang, J.; Hou, J.-T.; Wen, J.; Zhang, J.*; Yu, X.-Q.* “Iron-catalyzed direct amination of azoles using formamides or amines as nitrogen sources in air” Chem. Commun. 2011, 47, 3652-3654. Huang, Q.-D.; Zhong, G.-X.; Zhang, Y.; Ren, J.; Fu, Y.; Zhang, J.*; Zhu, W.; Yu, X.-Q.* “Cyclen-based cationic lipids for highly efficient gene delivery towards tumor cells” PLoS One 2011, 6(8), e23134. Huang, Q.-D.; Ou, W.-J.; Chen, H.; Feng, Z.-H.; Wang, J.-Y.; Zhang, J.*; Zhu, W.; Yu, X.-Q.* “Novel cationic lipids possessing protonated cyclen and imidazolium salt for gene delivery” Eur. J. Pharm. Biopharm. 2011, 78, 326-335. Yi, W.-J.; Feng, Z.-H.; Zhang, Q.-F.; Zhang, J.*; Li, L.-D.; Zhu, W.; Yu, X.-Q.* “Diol Glycidyl Ether-Bridged Cyclens: Preparation and Their Applications in Gene Delivery” Org. Biomol. Chem. 2011, 9, 2413-2421. Li, S.; Wang, Y.; Zhang, J.*; Yang, W.-H.; Dai, Z.-H.; Zhu, W.; Yu, X.-Q.* “Biodegradable cross-linked poly(amino alcohol esters) based on LMW PEI for gene delivery” Mol. Biosyst. 2011, 7(3), 1254-1262. Zhang, Q.-F.; Yang, W.-H.; Yi, W.-J.; Zhang, J.*; Ren, J.; Luo, T.-Y.; Zhu, W.; Yu, X.-Q.* “TACN-containing cationic lipids with ester bond: Preparation and application in gene delivery” Bioorg. Med. Chem. Lett. 2011, 21(23), 7045-7049. Wen, J.; Fu, Y.; Zhang, R.-Y.; Zhang, J.*; Chen, S.-Y.; Yu, X.-Q.* “A Simple and Efficient Synthesis of Pyrazoles in Water” Tetrahedron 2011, 67(49), 9618-9621. Xiang, Y.-Z.; Feng, Z.-H.; Zhang, J.*; Liao, Y.-L.; Yu, C.-J.; Yi, W.-J.; Zhu, W.; Yu, X.-Q.* “Linear cyclen-based polyamine as a novel and efficient reagent in gene delivery” Org. Biomol. Chem.2010, 8, 640-647. Zhang, J.*; Meng, X.-G.; Zeng, X.-C.; Yu, X.-Q.* “Metallomicellar Supramolecular Systems and Their Applications in Catalytic Reactions” Coordin. Chem. Rev. 2009, 253, 2166-2177. Xiang, Y.-Z.; Liao, Y.-L.; Zhang, J.*; Zhang, D.-W.; Chen, S.-Y.; Lu, Q.-S.; Zhang, Y.; Lin, H.-H.; Yu, X.-Q.* “Linear disulfide-containing low polymer as efficient DNA cleavage reagent” Bioorg. Med. Chem. Lett. 2009, 19, 3458-3460. Xiang, Y.-Z.; Wang, N.; Zhang, J.*; Li, K.; Zhang, Z.-W.; Lin, H.-H.; Yu, X.-Q.* “Novel Cyclen-Based Linear Polymer as a High-Affinity Binding Material for DNA Condensation” Sci. China Ser. B. 2009, 52(4), 483-488."

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