刘小华 - 四川大学

个人简介

1996.9-2000.6 湖北师范学院化学系学习，获理学学士学位 2000.9-2003.6 四川大学化学学院分析化学专业学习，获理学硕士学位 2003.9-2006.6 四川大学化学学院有机化学专业学习，获理学博士学位 2006.7-2010.6 四川大学化学学院副教授，硕士生导师 2010.7-至今四川大学化学学院教授，2012年担任博士生导师 2011年获教育部新世纪优秀人才计划资助；2012年获国家自然科学基金委优秀青年基金资助；2013年入选四川省学术和技术带头人后备人选；获霍英东青年教师基金资助；2015年入选第二届国家高层次人才特殊支持计划青年人才，享受国务院政府特殊津贴专家；2016年获国家杰出青年科学基金资助；2017年国家百千万人才工程入选者和有突出贡献中青年专家；2018年入选四川省学术和技术带头人；2020年获全国三八红旗手称号；2021年当选英国皇家化学会会士。

研究领域

主要从事新型手性催化剂的设计合成、不对称催化反应、手性药物和生理活性化合物的高效高选择性合成研究。

近期论文

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Nian Xu,† Maoping Pu,† Han Yu, Gaofei Yang, Xiaohua Liu,* Xiaoming Feng,* Iron-Catalyzed Asymmetric α-Alkylation of 2-Acylimidazoles via Dehydrogenative Radical Cross-Coupling with Alkanes, Angew. Chem. Int. Ed. 2024, 63, e202314256. Min Chen,† Longqing Yang,† Yuzhen Li, Yinhe Qu, Guihua Pan, Xiaoming Feng,* Xiaohua Liu,* Regioselective and Asymmetric Allylic Alkylation of Vinyl Epoxides for the Construction of Allylic Alcohols via Synergistic Catalysis, Sci. China Chem. 2024, 67, 542−550. Dong Zhang,† Maoping Pu,† Zhenzhong Liu, Yuqiao Zhou, Zhendong Yang, Xiaohua Liu,* Yun-Dong Wu,* and Xiaoming Feng,* Enantioselective anti-Dihalogenation of Electron-Deficient Olefin: A Triplet Halo-Radical Pylon Intermediate, J. Am. Chem. Soc. 2023, 145, 4808−4818. Qianwen He,† Mao-Ping Pu,† Zheng Jiang, Hongyu Wang, Xiaoming Feng,* Xiaohua Liu,* Asymmetric Epoxidation of Alkenes Catalyzed by a Cobalt Complex, J. Am. Chem. Soc. 2023, 145, 15611−15618. Guihua Pan, Maoping Pu, Hongyu Wang, Meijia Ying, Yi Li, Shunxi Dong, Xiaoming Feng, Xiaohua Liu,* Catalytic Enantioselective Nucleophilic Addition to Arynes by a New Quaternary Guanidinium Salt Based Phase-Transfer Catalyst, J. Am. Chem. Soc. 2023, 145, 26318−26327. Kaixuan Wang, Longqing Yang, Yi Li, Hongye Li, Zhili Liu, Lichao Ning, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Ring-Expansion of 3-Methyleneazetidines with α-Diazo Pyrazoamides towards Proline-Derivatives, Angew. Chem. Int. Ed. 2023, 62, e202307249. Tangyu Zhan, Liangkun Yang, Qiyou Chen, Rui Weng, Xiaohua Liu,* Xiaoming Feng,* Chiral Lewis Acid-Catalyzed Norrish Type II Cyclization to Synthesize α-Oxazolidinones via Enantioselective Protonation, CCS Chem. 2023, 5, 2101–2110. Shunxi Dong, Weidi Cao, Maoping Pu, Xiaohua Liu,* Xiaoming Feng,* Ligand-Acceleration in Chiral Lewis Acid Catalysis, CCS Chem. 2023, 5, 2717–2735. Zhikun Wu,† Xiying Zhang,† Nian Xu, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Aerobic Oxidative Radical Addition/Hydroxylation/1,4-Aryl Migration Reaction of Olefins, ACS Catal. 2023, 13, 815−823. Yuhao Mo, Qiyou Chen, Jinzhao Li, Dong Ye, Yuqiao Zhou, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Conjugate Addition of Cyanide to Chromones and β‑Substituted Cyclohexenones, ACS Catal. 2023, 13, 877−886. Shiyang Li, Cefei Zhang, Guihua Pan, Liangkun Yang, Zhishan Su, Xiaoming Feng, Xiaohua Liu,* Enantioselective Photochemical Carbene Insertion into C−C and C−H Bonds of 1,3-Diketones by a Guanidine-Amide Organocatalyst, ACS Catal. 2023, 13, 4656−4666. Xinyue Hu, Long Chen, Hongye Li, Qifan Xu, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Catalytic Hantzsch Dihydropyridine Synthesis, ACS Catal. 2023, 13, 6675−6682. Yongyan Zhang, Jin Wu, Lichao Ning, Qianping Chen, Xiaoming Feng, Xiaohua Liu,* Enantioselective Synthesis of Tetrasubstituted Allenes via Addition/Arylation Tandem Reaction of 2-Activated 1,3-Enynes, Sci. China Chem. 2023, 66, 526−533. Siyuan Wang, Yuqiao Zhou, Wanlong Xiao, Zegong Li, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Complex Tricyclo[3.2.2.0]nonenes from Racemic Norcaradienes: Kinetic Resolution via Diels–Alder Reaction, Chem. Sci. 2023, 14, 1844−1851. Peiran Ruan, Cefei Zhang, Jin Wu, Fengnan Xiao, Yongyan Zhang, Qingfa Tan, Zhishan Su, Xiaoming Feng, Xiaohua Liu,* Asymmetric [3+2]-cyclization of a-Iminoamide Surrogates to Construct 3,4-Diaminopyrrolidine-2,5-diones, Chem. Commun. 2023, 59, 8250−8253. Yanji Song, Shi Tang, Qianping Chen, Qingfa Tan, Weidi Cao, Xiaoming Feng, Xiaohua Liu,* Asymmetric Synthesis of Cyclopenta[b]indoles via Organocatalytic Formal (3 + 2) Cyclization of β-Ketoester with Azonaphthalene, Org. Chem. Front. 2023, 10, 2734–2739. Changli He, Xiaoxue Tang, Xin He, Yuqiao Zhou, Xiaohua Liu,* Xiaoming Feng,* Regio- and Enantioselective Conjugate Addition of β-Nitro α,β-Unsaturated Carbonyls to Construct 3-Alkenyl Disubstituted Oxindoles, Chin. Chem. Lett. 2023, 34, 107487. Wei Yang, Zhendong Yang, Long Chen, Yican Lu, Cefei Zhang, Zhishan Su, Xiaohua Liu,* Xiaoming Feng,* Chiral Nickel(II) Complex Catalyzed Asymmetric (3 + 2) Cycloaddition of α-Diazo Pyrazoleamides with 2-Siloxy-1-alkenes, Chin. Chem. Lett. 2023, 33, 107791. Jianglin Qiao, Shiyu Wang, Xiaohua Liu,* Xiaoming Feng,* Enantioselective [3+2] Cycloaddition of Donor-Acceptor Aziridines and Imines to Construct 2,5-trans-Imidazolidines, Chem. Eur. J. 2023, 29, e202203757. Qingfa Tan, Ning Guo, Linhan Yang, Fei Wang, Xiaoming Feng, and Xiaohua Liu,* Asymmetric Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides Using [1,2]-Phospha-Brook Rearrangement, J. Org. Chem. 2023, 88, 9332−9342. Zegong Li, Zi Zeng, Qi Tang, Ziwei Zhong, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of 3-Lactone Substituted 2-Oxindoles with Vicinal Quaternary Carbon Centers via Vinylogous Conjugate Addition, Synlett 2023, 34, 2405−2410. Weidi Cao, Xiaohua Liu,* Recent Advances on Catalytic Enantioselective Protonation for Construction of α-Tertiary Carbonyl Compounds, Chin. J. Org. Chem. 2023, 43, 961–973. Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Rearrangements with α‑Diazocarbonyl Compounds, Acc. Chem. Res. 2022, 55, 415−428. Xiaobin Lin,# Maoping Pu,# Xinpeng Sang, Shiyang Li, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Asymmetric Catalytic (2+1) Cycloaddition of Thioketones to Synthesize Tetrasubstituted Thiiranes, Angew. Chem. Int. Ed. 2022, 61, e202201151. Wanlong Xiao, Lichao Ning, Shuang Xin, Shunxi Dong, Xiaohua Liu,* XiaomingFeng,* Enantioselective [2+2] Cycloaddition of Allenyl Imidewith Mono-, or Disubstituted Alkenes, Angew. Chem. Int. Ed. 2022, 61, e202211596. Lifeng Wang, Yuqiao Zhou, Zhishan Su, Fengcai Zhang, Weidi Cao, Xiaohua Liu,* Xiaoming Feng,* [3,3]-Sigmatropic Rearrangements of Naphthyl 1-Propargyl Ethers: para-Propargylation and Catalytic Asymmetric Dearomatization, Angew. Chem. Int. Ed. 2022, 61, e202211785. Han Yu, Tangyu Zhan, Yuqiao Zhou, Long Chen, Xiaohua Liu,* Xiaoming Feng,* Visible-Light-Activated Asymmetric Addition of Hydrocarbons to Pyridine-Based Ketones, ACS Catal. 2022, 12, 5136−5144. Yao Luo, Qi Wei, Liangkun Yang, Yuqiao Zhou, Weidi Cao, Zhishan Su, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Radical Hydroacylation of α,β-Unsaturated Carbonyl Compounds with Aldehydes by Triplet Excited Anthraquinone, ACS Catal. 2022, 12, 12984−12992. Jiawen Lang, Siyuan Wang, Changli He, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Isochromanone Derivatives via Trapping Carboxylic Oxonium Ylides and Aldol Cascade, Chem. Sci. 2022, 13, 1163−1168. Linfeng Hu, Jinzhao Li, Yongyan Zhang, Xiaoming Feng, Xiaohua Liu,* Enantioselective [1,2]-Stevens Rearrangement of Thiosulfonates to Construct Dithio-substituted Quaternary Carbon Centers, Chem. Sci. 2022, 13, 4103–4108. Yi Li, Shuang Xin, Rui Weng, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Chromanone Lactones via Vinylogous Conjugate Addition of Butenolide to 2-Ester Chromones, Chem. Sci. 2022, 13, 8871–8875. Peiran Ruan, Qiong Tang, Zun Yang, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Formal [2+2+2] Cycloaddition of 1,3,5-Triazinanes to Construct Tetrahydropyrimidin-4-one Derivatives, Chem. Commun. 2022, 58, 1001−1004. Chaoqi Ke, Qiuhui Cao, Yao Luo, Xiaohua Liu,* Xiaoming Feng,* Catalytic Asymmetric Amination of Azlactones with Azobenzenes, Chem. Commun. 2022, 58, 5881−5884. Qingfa Tan, Qianping Chen, Zitong Zhu, Xiaohua Liu,* Asymmetric Organocatalytic Sulfenylation for the Construction of a Diheteroatom-bearing Tetrasubstituted Carbon Centre, Chem. Commun. 2022, 58, 9686–9689. Yi Li, Wang-Yuren Li, Xiaoxue Tang, Xiaohua Liu,* Xiaoming Feng,* Synthesis of Chiral Pyridine-oxazolines via Catalytic Asymmetric Heine Reaction of meso-N-(2-picolinoyl)-aziridines, Org. Chem. Front. 2022, 9, 1531−1535. Jinzhao Li, Lichao Ning, Qingfa Tan, Xiaoming Feng, Xiaohua Liu,* Asymmetric Sonogashira C(sp3 )-C(sp) Bond Coupling Enabled by Copper(I) Complex of New Guanidine-hybrid Ligand, Org. Chem. Front. 2022, 9, 6312−6318. Fei Tan,# Maoping Pu,# Jun He, Jinzhao Li, Jian Yang, Shunxi Dong, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Catalytic Asymmetric Homologation of Ketones with α-Alkyl-α-diazoesters, J. Am. Chem. Soc. 2021, 143, 2394−2402. Wei Yang,# Maoping Pu,# Xiaobin Lin, Min Chen, Yanji Song, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Enantioselective Formal Vinylogous N−H Insertion of Secondary Aliphatic Amines Catalyzed by a High-Spin Cobalt(II) Complex, J. Am. Chem. Soc. 2021, 143, 9648−9656. Wen Liu,# Maoping Pu,# Jun He, Tinghui Zhang, Shunxi Dong, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of , a,b-Unsaturated Carbonyl Compounds, J. Am. Chem. Soc. 2021, 143, 11856−11863. Long Chen,# Maoping Pu,# Shiyang Li, Xinpeng Sang, Xiaohua Liu,* Yun-Dong Wu,* and Xiaoming Feng,* Enantioselective Synthesis of Nitriles Containing a Quaternary Carbon Center by Michael Reactions of Silyl Ketene Imines with 1‑Acrylpyrazoles, J. Am. Chem. Soc. 2021, 143, 19091–19098. Yong Xia, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Reactions of Donor-Acceptor Cyclopropanes, Angew. Chem. Int. Ed. 2021, 60, 9192–9204. Jinzhao Li, Yuhao Mo, Liqiao Yan, Xiaoming Feng, Zhishan Su,* Xiaohua Liu,* Organocatalytic Stereoselective [8+2] Cycloaddition of Tropones with Azlactones, CCS Chem. 2021, 3, 784–793. Xia Zhong, Ziwei Zhong, Zhikun Wu, Zhen Ye, Yuxiang Feng, Shunxi Dong, Xiaohua Liu,* Qian Peng,* Xiaoming Feng,* Chiral Lewis Acid-bonded Picolinaldehyde Enables Enantiodivergent Carbonyl Catalysis in Mannich/Condensation Reaction of Glycine Ester, Chem. Sci. 2021, 12, 4353–4360. Lihua Xie, Yi Li, Shunxi Dong, Xiaoming Feng, Xiaohua Liu,* Catalytic Asymmetric Formal [3+2] Cycloaddition of Isatogens with Azlactones to Construct Indolin-3-one Derivatives, Chem. Commun., 2021, 57, 239−242. Qingfa Tan, Han Yu, Yao Luo, Fenzhen Chang, Xiaohua Liu,* Yuqiao Zhou,* Xiaoming Feng,* Asymmetric Catalytic [4+3] Cycloaddition of ortho-Quinone Methides with Oxirances, Chem. Commun., 2021, 57, 3018−3021. Linfeng Hu, Weidi Cao, Kaixuan Wang, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Dihydrocarbazoles through Friedel-Crafts Alkylation/annulation Sequential Reaction of Indoles, Chem. Commun., 2021, 57, 13138−13141. Jian Xu, Runze Li, Nian Xu, Xiaohua Liu,* Fei Wang,* Xiaoming Feng,* Enantioselective [4 + 2] Cycloaddition/Cyclization Cascade Reaction and Total Synthesis of cis-Bis(cyclotryptamine) Alkaloids, Org. Lett. 2021, 23, 1856−1861. Qianwen He, Dong Zhang, Fengcai Zhang, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents, Org. Lett. 2021, 23, 6961−6966. Wenkun Yang, Pei Dong, Jian Xu, Jian Yang, Xiaohua Liu,* Xiaoming Feng,* Enantioselective synthesis of 3-substituted 3-amino-2-oxindoles via amination with anilines, Chem. Eur. J. 2021, 27, 9272−9275. Chaoqi Ke, Zhenzhong Liu, Sai Ruan, Xiaoming Feng, Xiaohua Liu,* Organocatalytic Asymmetric Synthesis of Benzothiazolopyrimidines via a [4 + 2] Cycloaddition of Azlactones with 2-Benzothiazolimines, Org. Chem. Front. 2021, 8, 5705−5709. Peng Zhao, Zegong Li, Jun He, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic 1,3-Dipolar Cycloaddition of α-Diazoesters for Synthesis of 1-Pyrazoline-based Spirochromanones and Beyond, Sci. China Chem. 2021, 64, 1355−1360. Peng Zhao, Zi Zeng, Xiaoming Feng,* Xiaohua Liu,* Multisubstituted Pyrazole Synthesis via [3+2] Cycloaddition/Rearrangement/N-H Insertion Cascade Reaction of α-Diazoesters and Ynones, Chin. Chem. Lett. 2021, 32, 132−135. Yi Li, Hao Pan, Wangyuren Li, Xiaoming Feng, Xiaohua Liu,* Enantioselective Nucleophilic Aromatic Substitution Reaction of Azlactones to Synthesize Quaternary α-Amino Acid Derivatives, Synlett 2021, 32, 587−592. Weidi Cao, Xiaohua Liu,* Asymmetric Formal Hetero-Ene Reaction of Allylgold Intermediates, Chin. J. Org. Chem. 2021, 41, 857−858. Dong Zhang, Zhisan Su, Qianwen He, Zhikun Wu, Yuqiao Zhou, Chenjing Pan, Xiaohua Liu,* Xiaoming Feng,* Diversified Transformations of Tetrahydroindolizines to Construct Chiral 3-Arylindolizines and Dicarbofunctionalized 1,5-Diketones, J. Am. Chem. Soc. 2020, 142, 15975−15985. Xiying Zhang, Wangbin Wu, Weidi Cao, Han Yu, Xi Xu, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Radical-Polar Crossover Reactions of Indanonecarboxamides with Alkenes, Angew. Chem. Int. Ed. 2020, 59, 4846−4850. Tengfei Kang, Liuzhen Hou, Sai Ruan, Weidi Cao, Xiaohua Liu,* Xiaoming Feng,* Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles, Nat. Commun. 2020, 11, 3869. Xiaobin Lin, Zheng Tan, Wenkun Yang, Wei Yang, Xiaohua Liu,* Xiaoming Feng,* Chiral Cobalt(ΙΙ) Complex Catalyzed Asymmetric [2,3]-Sigmatropic Rearrangement of Allylic Selenides with α-Diazo Pyrazoleamides, CCS Chem. 2020, 2, 1423–1433. Jian Xu, Ziwei Zhong, Mingyi Jiang, Yuqiao Zhou, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Concise Synthesis of Hetero-3,3ʹ-Bisoxindoles for the Construction of Bispyrroloindoline Alkaloids, CCS Chem. 2020, 2, 1894–1902. Zhen Wang, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalysis Enabled by Chiral N,N'-Dioxide–Nickel(II) Complexes, Aldrichimica ACTA, 2020, 53, 3−10. Qianchi Lin, Bowen Hu, Xi Xu, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Chiral N,Nʹ-Dioxide/Mg(OTf)2 Complex-Catalyzed Asymmetric [2,3]-Rearrangement of in situ Generated Ammonium Salts, Chem. Sci. 2020, 11, 3068−3073. Bin Shen, Qianwen He, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Chiral Cobalt(II) Complex Catalyzed Enantioselective Aza-Piancatelli Rearrangement/Diels-Alder Cascade Reaction, Chem. Sci. 2020, 11, 3862−3867. Lifeng Wang, Pengfei Zhou, Qianchi Lin, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Chiral Fe(II) Complex Catalyzed Enantioselective [1,3] O-to-C Rearrangement of Alkyl Vinyl Ethers and Synthesis of Chromanols and Beyond, Chem. Sci. 2020, 11, 10101−10106. Sai Ruan, Xia Zhong, Quangang Chen, Xiaoming Feng, Xiaohua Liu,* An Asymmetric Hydrocyanation/Michael reaction of a-Diazoacetates via Cu(I)/Chiral Guanidine Catalysis, Chem. Commun. 2020, 56, 2155−2158. Wei Yang, Xiaobin Lin, Yongyan Zhang, Weidi Cao, Xiaohua Liu,* Xiaoming Feng,* Nickel(II)-catalyzed asymmetric thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles, Chem. Commun. 2020, 56, 10002−10005. Dong Zhang, Shunxi Dong, Qianwen He, Yao Luo, Yun Liu, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Dicarbofunctionalization of (E)-Alkenyloxindoles with Pyridinium Salts by Chiral Lewis Acid/Photo Relay Catalysis, Chem. Commun. 2020, 56, 12757−12760. Haipeng Hu, Jinxiu Xu, Fang Wang, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Chiral ScIII-N,N′‑Dioxide-Catalyzed 1,3-Dipolar Cycloaddition of Diaziridines with Chalcones, Org. Lett. 2020, 22, 93−97. Xi Xu, Shunxi Dong, LiLi Feng, Sijing Wang, Xiaohua Liu,* Xiaoming Feng,* Kinetic Resolution of Propargylic Ethers via [2,3]-Wittig Rearrangement to Synthesize Chiral α‑Hydroxyallenes, Org. Lett. 2020, 22, 2692−2696. Hang Zhang, Yao Luo, Chenhao Zhu, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Catalytic Asymmetric Addition Reactions of Formaldehyde N,Nʹ‑Dialkylhydrazone to Synthesize Chiral Nitrile Derivatives, Org. Lett. 2020, 22, 5217−5222.