个人简介

Pew Scholar, 2006 School of Biological Sciences Golden Apple Award in Teaching Excellence, 2007 School of Biological Sciences Teaching Excellence Award, the Division of Undergraduate Education, 2009 Outstanding Professor from UC Irvine School of Biological Sciences, selected by the graduating seniors, 2010 UCI Chancellor's Fellow, 2011 UCI Chancellor's Award for Excellence in Undergraduate Research, 2013 Fellow of the Royal Society of Chemistry (FRSC), 2014 AAAS Fellow, 2016

研究领域

Chemical Biology/Organic and Synthetic

Nature has a unique approach to generate a huge variety of natural products in a combinatorial fashion. The biosynthesis of these compounds is often accomplished by multi-domain enzyme mega-complexes with remarkable architectures. The goal of the Tsai lab is to understand the sequence-structure-function relationship of these multi-domain complexes, so that we may biosynthesize chemically complex natural products in an efficient fashion. Our research is highly inter-disciplinary: in terms of chemistry, our research leads to libraries of de novo natural product analogs in a combinatorial fashion with high yield and efficiency; in terms of biology, our research will help understand the architecture and catalysis of these enzyme complexes. Techniques utilized include organic synthesis, combinatorial biosynthesis, molecular cloning, enzymology, bioinformatics and X-ray crystallography. The elucidation of molecular features that govern natural product biosynthesis will help us understand how natural products are made and evolved in nature, and will enable rational design of de novo natural products for drug discovery.

近期论文

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Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics Lauren Ray, Timothy Valentic, Takeshi Miyazawa, David M. Withall, Lijiang Song, Hiroyuki Osada,Shunji Takahashi,Shiou-Chuan Tsai,* and Gregory L. Challis* Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis Valentic TR, Jackson DR, Brady SF, Tsai SC. Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain. Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai SC Angew Chem Int Ed Engl. 2016, in press Insights into complex oxidation during BE-7585A biosynthesis: structural determination and analysis of the polyketide monooxygenase BexE. Jackson DR, Yu X, Wang G, Patel AB, Barajas JF, Sasaki E, Metsa-Ketala M, Liu HW, Rohr J, Tsai SC. ACS Chem Biol. 2016, 11, 1137 The alga Ochromonas danica produces bromosulfolipids. White AR, Duggan BM, Tsai SC, Vanderwal CD Org Lett. 2016, 18, 1124 Structural insights into anthranilate priming during type II polyketide biosynthesis. Jackson D, Tu SS, Nguyen M, Barajas J, Schaub A, Krug D, Pistorius D, Luo R, Müller R, Tsai SC. ACS Chem Biol. 2016, 11, 95