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个人简介

张晓清,博士,副教授,硕士生导师。1998.09-2002.07,就读于西南大学化学化工学院化学教育专业,获理学学士学位。2004.09-2009.07,就读于重庆医科大学检验医学院临床检验诊断学专业,硕博连读,获医学博士学位。2007.03-2009.05,在南京大学生命分析化学国家重点实验室交流学习。2015.12-2016.12,在美国肯特州立大学化学与生物学系做访问学者。2002.09至今,在重庆医科大学检验医学院从事教学科研工作,主要研究方向:临床疾病诊断的新方法与新技术研究,疾病早期诊断方法研究,疾病诊断的分子标志物,生物活性物质分离分析新技术及临床应用。获得多项国家级、省级科研课题,其中以项目负责人身份获批一项国家自然科学基金项目,两项重庆市市级自然科学基金项目,一项重庆市教委科研项目。发表科研论文19篇,其中以第一作者或通讯作者发表的SCI论文8篇,获批国家发明专利授权1项,参编教材1本,参编专著1部。

研究领域

临床疾病诊断新方法研究/疾病诊断的分子标志物

知识产权 获批国家发明专利授权:一种快速检测血浆吲哚的电化学传感器,授权号:CN106896147B,排名:1 获批国家发明专利授权:一种高灵敏的血清总胆汁酸电化学检测方法,授权号:CN107764877B,排名:3 获批国家发明专利授权:血清总胆汁酸检测试剂盒及其使用方法,授权号:CN103616431A,排名:3 科研项目 国家自然科学基金青年科学基金项目:血清胆汁酸谱检测及其在妊娠肝内胆汁淤积症中的作用[81401228] 重庆市科学技术委员会基础科学与前沿技术研究项目:血清胆汁酸谱检测新方法研究及临床应用[cstc2014jcyjA10082] 重庆市教委科技项目科学技术研究项目:血浆吲哚及衍生物的高灵敏检测新方法和临床应用[KJQN201800437] 重庆市科委市级重点实验室:微流控芯片-电化学检测分析妊娠肝内胆汁淤积症患者血清胆汁酸 中央财政经费特色重点学科基金:微流控芯片分析血清胆汁酸谱用于妊娠肝内胆汁淤积症的诊断和分度

近期论文

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主要学术论著: GangTian,MinDing,BiaoXu,YifanHe,WenjingLyu,MingchaoJin,XiaoqingZhang*.Anovelelectrochemicalbiosensorforultrasensitivedetectionofserumtotalbileacidsbasedonenzymaticreactioncombinedwiththedoubleoxidationcircularamplificationstrategy.Biosensors&Bioelectronics,2018,118:31-35. ZhangXiaoqing,ZhuMingsong,XuBiao,YueCui,GangTian,ZhenghuShi,MinDing*Indirectelectrochemicaldetectionfortotalbileacidsinhumanserum.Biosensors&Bioelectronics,2016,85:563-567. WenjingLyu#,XiaoqingZhang#,ZhongZhang,XiaoChen,YingZhou,HongChen,HaoranWang,MinDing*.Asimpleandsensitiveelectrochemicalmethodforthedeterminationofcapsaicinoidsinchillipeppers.Sensors&Actuators:B.Chemical,2019,288:65-70.(共同第一) MingchaoJin#,XiaoqingZhang#,QianNaZhen,YiFanHe,XiaoChen,WenjingLyu,RunchuanHan,MinDing*.AnelectrochemicalsensorforindoleinplasmabasedonMWCNTs-chitosanmodifiedscreen-printedcarbonelectrode.Biosensors&Bioelectronics,2017,98:392.(共同第一) XiaoqingZhang,WenpingDeng,YannaBan,JieyingGao,MinDing*.Ahighlysensitiveelectricallydrivenelectrochemiluminescentassayforquantification.Analyst,2013,138:5074-5080. XiaoqingZhang,YunHe,MinDing*.SimultaneousdeterminationoftryptophanandkynurenineinplasmasamplesofchildrenpatientswithKawasakidiseasebyhigh-performanceliquidchromatographywithprogrammedwavelengthultravioletdetection.JournalofChromatographyB,2009,877:1678–1682. ZhengHuShi#,XiaoQingZhang#,QianNaZhen,MingZuo,GangTian,YiFanHe,MinDing*.Directelectrochemicalmeasurementofmetanephrinesinspoturinesamplesforthediagnosisofphaeochromocytomas.ScientificReports,2017,7(1).(共同第一) XiaoChen#,XiaoqingZhang#,BiaoXu,YueCui,YifanHe,TingYang,YongShao,MinDing*.Theurinarybileacidprofilinganalysisofasymptomatichypercholanemiaofpregnancy:Apseudo-targetedmetabolomicsstudy.ClinicaChimicaActa,2019,497:67-75.(共同第一) YueCui,BiaoXu,XiaoqingZhang,YifanHe,YongShao,MinDing*.Diagnosticandtherapeuticprofilesofserumbileacidsinwomenwithintrahepaticcholestasisofpregnancy-apseudo-targetedmetabolomicsstudy.ClinicaChimicaActa,2018,483:135-141.(被国际著名医学杂志Lancet引用) LiMa,XiaoqingZhang,FengPan,YueCui,TingYang,LinlinDeng,YongShao,MinDing*.Urinarymetabolomicanalysisofintrahepaticcholestasisofpregnancybasedonhighperformanceliquidchromatography/massspectrometry.ClinicaChimicaActa,2017,471:292-297. GangTian,XiaoqingZhang,MingsongZhu,ZhongZhang,ZhenghuShi,MinDing*.Quantificationofethanolinplasmabyelectrochemicaldetectionwithanunmodifiedscreenprintedcarbonelectrode.ScientificReports,2016,6:23569. LiMa,XiaoqingZhang,DaxueZhou,YueCui,LinlinDeng,TingYang,YongShao,MinDing*.FeasibilityofurinarymicroRNAprofilingdetectioninintrahepaticcholestasisofpregnancyanditspotentialasanon-invasivebiomarker.ScientificReports,2016,6:31535. YuchaoLi,XiaoqingZhang,JianboChen,ChengyaFeng,YifanHe,YongShao,MinDing*.Targetedmetabolomicsofsulfatedbileacidsinurineforthediagnosisandgradingofintrahepaticcholestasisofpregnancy.Genes&Diseases,2018,5:358-366. MinglinOu,XiaoqingZhang,YongDai,JieyingGao,MingsongZhu,XiangchunYang,YuchaoLi,TingYangandMinDing*.IdentificationofpotentialmicroRNA–targetpairsassociatedwithosteopetrosisbydeepsequencingiTRAQproteomicsandbioinformatics.EuropeanJournalofHumanGenetics,2014,22:625-632. MingZuo,QiannaZhen,XiaoqingZhang,WenbiZou,XiangchunYang,GangTian,ZhenghuShi,QifuLi,MinDing*.HighspecificityofspoturinaryfreemetanephrinesindiagnosisandprognosisofpheochromocytomasandparagangliomasbyHPLCwithelectrochemicaldetection.ClinicaChimicaActa,2018,478:82-89. JieyingGao,BiaoXu,XiaoqingZhang,YueCui,LinlinDeng,ZhenghuShi,YongShao,MinDing*.Associationbetweenserumbileacidprofilesandgestationaldiabetesmellitus:Atargetedmetabolomicsstudy.ClinicaChimicaActa,2016,459:63-72. MingZuo,JieyingGao,XiaoqingZhang,YueCui,ZimianFan,MinDing*.Capillaryelectrophoresiswithelectrochemiluminescencedetectionforthesimultaneousdeterminationofcisatracuriumbesylateanditsdegradationproductsinpharmaceuticalpreparations.JournalofSeparationScience,2015,38,2332-2339. LiMa,JunHe,XiaoqingZhang,YueCui,JieyingGao,XiufangTang,MinDing*.Determinationoftotal,free,andreducedhomocysteineandrelatedaminothiolsinuremicpatientsundergoinghemodialysisbyprecolumnderivatizationHPLCwithfluorescencedetection.RSCADVANCES,2014,4:58412-58416. JieyingGao,TingYang,MaoYe,XiaoqingZhang,GangTian,QiannaZhen,MinDing*.High-performanceliquidchromatographyassaywithprogrammedflowelutionforcisatracuriuminhumanplasma:Applicationtopharmacokineticsininfantsandchildren,JournalofChromatographyB,2014,955-956:58-63. 著作教材 《生物分析化学》专著,科学出版社,鞠熀先等主编,参编。 《无机及分析化学习题集》教材,人民卫生出版社,潘国石主编,参编

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