个人简介

Presidential Meritorious Service Award, Univ. Maryland 1991; Chancellor's Professor, UCI 2000 Brodie Award for Drug Metabolism Amer. Soc. of Pharmacology and Experimental Therapeutics, 2004 Amer. Chem. Soc. Gordon Hammes Lectureship 2014 Appointments: Research Scientist UCSD Dept. Chemistry from 1973-1983; Principal Res. Scientist at Genex Corp. from 1983-1984; Director of Protein Engineering at Genex Corp. from 1984-1987; Director for the Univ. of Maryland's Center for Advanced Res. in Biotehcnology and Professor of Chemistry, Univ. of Maryland, College Park from 1987-1991; Professor at UCI since 1992.

研究领域

Chemical Biology

Protein crystallography, protein engineering, heme enzyme structure and function.

近期论文

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Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB. J Med Chem. 2017 Apr 19. doi: 10.1021/acs.jmedchem.7b00259. [Epub ahead of print] Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4. Sevrioukova IF, Poulos TL. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):486-491. doi: 10.1073/pnas.1616198114. Epub 2016 Dec 28. Nitric oxide synthase and structure-based inhibitor design. Poulos TL, Li H. Nitric Oxide. 2017 Feb 28;63:68-77. doi: 10.1016/j.niox.2016.11.004. Epub 2016 Nov 23. A Comparative Analysis of the Effector Role of Redox Partner Binding in Bacterial P450s. Batabyal D, Lewis-Ballester A, Yeh SR, Poulos TL. Biochemistry. 2016 Nov 29;55(47):6517-6523. Epub 2016 Nov 15. Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors. Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL. Biochemistry. 2016 Oct 4;55(39):5587-5594. Epub 2016 Sep 21.