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个人简介

学习和工作简历: 1983年9月-1987年7月:武汉大学化学系四年制本科生; 1987年9月-1990年7月:武汉大学化学系三年制硕士生; 1990年8月-1993年12月::北京大学化学与分子工程学院四年制博士生; 1993年12月-1995年11月:中科院研究生院化学部博士后; 1995年12月-现在:湖北大学生命科学学院教授、博士生导师。 承担科研项目情况: 1.杜仲叶、山麦冬标准提取物研究。01年武汉市科委重大科技攻关项目(50万,No.20016001008),主持人 2.指纹图谱应用示范研究。科技部十五攻关项目(中医药现代化研究与产业化开发)(程翼宇主持,No.2001BA701A01),联合申报单位负责人(分配经费10万) 3.中药标准提取物及其指纹图谱研究。湖北省青年杰出人才科学基金(10万,No.2002AC004),主持人 4.慢性肝炎中医“证”分型的分子基础研究。国家重大基础研究前期专项(30万,No.2002ccc00300),主持人 5.用于中药临床前安全性评价的毒理芯片开发研究。湖北省科技厅(6万,No.2004AA303B05)和武汉市科技局重点攻关项目(10万,No.20036003042),主持人 6.确有疗效复方中药痹祺胶囊的药代动力学研究。07年国家自然科学基金重点项目(刘昌孝院士主持,No.30630075),联合申报单位主持人(分配经费35万) 7.复方脉君安片的药动学与分子药理学研究。湖北省高等学校优秀中青年团队计划项目(32万,No.T200807),主持人 8.浓缩型脉君安片临床前研究。湖北省发改委生物产业专项项目(No.鄂发改高技[2008]1365号-1,40万),主持人 9.抗乙肝病毒药物筛选关键技术。湖北省发改委生物产业专项项目(湖北省生物产业专项,No.鄂发改投资[2009]1734号,50万),主持人 10.与乙型病毒性肝炎病毒生活周期相关的细胞因子或靶分子。艾滋病和病毒性肝炎等重大传染病防治国家科技重大专项课题(吴建国主持,No.2008ZX10204),联合申报单位负责人(分配经费20万) 获得的授权发明专利 1.陈勇,李紫,蔡敏。山麦冬多糖提取工艺。发明专利,专利号ZL02147758.2 2.韩凤梅,杜鹏,郭小龙,陈勇。一种以枸杞酒渣为原料制备高免疫调节活性枸杞多糖的酶解工艺。发明专利,专利授权号ZL200710052400.7 3.陈勇,韩凤梅,张继业,张仙,王恒松。一种服用剂量小的浓缩型脉君安片或胶囊配方及其制备方法。发明专利,专利授权号ZL200810048199.X

研究领域

主要研究领域:主要从事分子药理学和药代动力学研究

近期论文

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1.HuaixiaChen,YongChen,HongWang,PengDu,FengmeiHan,HuashanZhang.AnalysisofscopolamineanditseighteenmetabolitesinraturinebyLCtandemmassspectrometry.Talanta,2005,67:984-991 2.HuaixiaChen,HongWang,YongChen,HuangshanZhang.Liquidchromatography-tandemmassspectrometryanalysisofanisodamineanditsphaseIandIImetabolitesinraturine.J.chromatographyB,2005,824:21-29 3.YongChen,HuaixiaChen,PengDu,FengmeiHan,HuashanZhang,TheAnalysisofAnisodineandtheIdentificationofTwentyofItsMetabolitesinRatUrinebyLiquidChromatography-TandemMassSpectrometry.Chromatographia,2005,62:563-569 4.HuaixiaChen,YongChen,PengDu,FengmeiHan,HongWang,HuashanZhang.Sensitiveandspecificliquidchromatographic-tandemmassspectrometricassayforatropineanditselevenmetabolitesinraturine.J.PharmaceuticalandBiomedicalAnalysis,2006,40:142 5.HANFeng-Mei,CHENGMing,XIAQi-Song,CHENYong.Geneexpressionprofileinimmunologicallyinjuredlivercellofmice.ScienceinChinaSeriesC-LifeSciences,2006,49(5):454-459 6.M.M.Zhu,H.X.Chen,F.M.Han,Y.Chen.AnalysisofArecolineandIdentificationofItsMetabolitesinRatUrinebyLiquidChromatography-TandemMassSpectrometry.Chromatographia,2006,64(11/12):705-708 7.H.X.Chen,Y.Chen,P.Du,F.M.Han.LC-MSforidentificationandelucidationofthestructureofin-vivoandin-vitrometabolitesofatropine.Chromatographia,2007,65:413-418 8.MingmingZhu,FengmeiHan,HuaixiaChen,ZhihongPengYongChen.Identificationofpalmatineanditsmetabolitesinraturinebyliquidchromatography-tandemmassspectrometry.Rapidcommunicationsinmassspectrometry,2007,21(13):2019-2022 9.YongChen,Xiao-mingZhang,Feng-meiHan,PengDu,Qi-songXia.GeneexpressionprofilinganalysesofinjuredmiceliversbyLeigongteng(TripterygiumWilfordiiHook.f.).WorldJournalofgastroenterology,2007,13(26):3619-3624 10.F.M.Han,Z.H.Peng,W.Song,H.M.Zhang,M.M.Zhu,Y.Chen.Identificationofdauricineanditsmetabolitesinraturinebyliquidchromatography-tandemmassspectrometry.J.ofChromatographyB,2007,854(1/2):1-7 11.HuaixiaChen,YongChen,PengDu,FengmeiHan.Structuralelucidationofin–vivoandin-vitrometabolitesofanisodinebyliquidchromatography-tandemmassspectrometry.J.ofPharmaceuticalandBiomedicalAnalysis.2007,44(3):773-778 12.Y.Chen,Z.H.Peng,M.M.Zhu,F.M.Han.Chromatographictandemmassspectrometricdetectionofpapaverineanditsmajormetabolitesinraturine.InternationalJ.ofMassSpectrometry,2007,266:114-121 13.B.Y.Ge,H.X.Chen,F.M.Han,Y.Chen.IdentificationofAmygdalinanditsmajormetabolitesinRatUrinebyLC-MS/MS.J.ofChromatographyB,2007,857:281-286 14.WeiSong,ZhihongPeng,BaoyingGe,FengmeiHan,YongChen.Identificationofmetabolitesoflobelineintheraturinebyliquidchromatography-tandemmassspectrometry.InternationalJ.ofMassSpectrometry,2007,269:131-137 15.Y.Chen*;Z.H.Peng;W.Song;M.M.Zhu;F.M.Han.ChromatographicTandemMassSpectrometricDetectionofPhysostigmineanditsMajorMetabolitesinRatUrine.AnalyticalLetters,2007(40):3256-3266 16.Y.Chen,W.Song,Z.H.Peng,B.Y.Ge,F.M.Han.Identificationofmetabolitesoftectoridininvivoandinvitrobyliquidchromatography-tandemmassspectrometry.J.ofPharmacyandPharmacology,2008,60:1-8 17.Yizhang,WenhuaWu,FengmeiHan,YongChen.LC/MS/MSforidentificationofinvivoandinvitrometabolitesofjatrorrhizine.BiomedicalChromatography,2008,22(12):1360-1367(SCI) 18.QianC.Yang,WenH.Wu,FengM.Han,YongChen.Identificationofinvivoandinvitrometabolitesofpalmatinebyliquidchromatography-tandemmassspectrometry.J.ofPharmacyandPharmacology,2009,61:647-652 19.XingxingKong,HengFan,XiaojunLiu,RuiWang,JichaoLiang,NishithGupta,YongChen,FudeFang,YongshengChang.PeroxisomeProliferator-ActivatedReceptorγCoactivator-1αEnhancesAntiproliferativeActivityof5′-Deoxy-5-FluorouridineinCancerCellsthroughInductionofUridinePhosphorylase.MolecularPharmacology,2009,76:854-860 20.PengZH,SongW,HanFM,ChenY.Invivoandinvitrostudyofpapaverineanditsmajormetabolites.ActaPhamaceuticaSinica,2009(44):95-100 21.Feng-meiHan,Qian-chengYang,PengDu,Wen-huaWu,YongChen.Themetabolismofstrychnineinratlivermicrosomesandmetabolicinteractionwithglycyrrheticacidinvitro.AsianJournalofPharmacodynamicsandPharmacokinetics,2009,9(4):301-312 22.F.M.Han,M.M.Zhu,H.X.Chen,Y.Chen.Identificationofsophoridineanditsmetabolitesinraturinebyliquidchromatography-tandemmassspectrometry.AnalyticalLetters,2010,43(1):45-54 23.Liu-LuanZhu,YangLiu,An-FangCui,DiShao,Ji-ChaoLiang,Xiao-JunLiu,YongChen,NishithGupta,Fu-DeFang,Yong-ShengChang.PGC-1αcoactivatesestrogen-relatedreceptor-αtoinducetheexpressionofglucokinase.AmJPhysiolEndocrinolMetab.2010,298:1210–E1218. 24.XingxingKong,RuiWang,YuanXue,XiaojunLiu,HuabingZhang,YongChen,FudeFang,YongshengChang.Sirtuin3,aNewTargetofPGC-1a,PlaysanImportantRoleintheSuppressionofROSandMitochondrialBiogenesis.PLoSOne.2010,5:1-13 25.YangQC,HanFM,XiongYQ,XingPP,ChenY.ThemetabolismofglycyrrheticacidinratlivermicrosomesandinvitrometabolicinteractionwithsixCYP450probesubstrates.AsianJofPharmacodynamicsandPharmacokinetics,2010,10(4):310-319 26.LiLiu,JuanXiao,ZhihongPeng,YongChen.InvitrometabolismofglycyrrheticacidbyhumancytochromeP450.ActaPhamaceuticaSinica,2011,46(1):81-87 27.XINGPan-pan,WUWen-hua,DUPeng,HANFeng-mei,CHENYong.EffectsofbrucinecombinedwithglycyrrhetinicacidorliquiritinonrathepaticcytochromeP450activitiesinvivo[J].ActaPharmaceuticaSinica2011,46(5):573-580. 28.QianGao,Jun-junWang,Feng-meiHan,YongChen.EffectofstrychninehydrochlorideonlivercytochromeP450mRNAexpressionandmonooxygenaseactivitiesinrat[J].ActaPharmaceuticaSinicaB,2011;1(2):121–128. 29.AijunQiao,JichaoLiang,YaojunKe,ChenghongLi,YingCui,LianShen,HuabingZhang,AnfangCui,XiaojunLiu,ChangzhengLiu,YongChen,YiZhu,YoufeiGuan,FudeFang,andYongshengChang.MousePatatin-LikePhospholipaseDomain-Containing3InfluencesSystemicLipidandGlucoseHomeostasis[J].Hepatology,2011,54(2):509-521. 30.Zhi-hongPeng,Jun-junWang,PengDu,YongChen.Identificationofinvivoandinvitrometabolitesoftriptolidebyliquidchromatography–tandemmassspectrometry[J].JournalofPharmaceuticalandBiomedicalAnalysis,2012,70:624–630. 31.JichaoLiang,FengmeiHan,YongChen.Anelectrochemicalmethodforhighsensitivedetectionofnicotineanditsinteractionwithbovineserumalbumin[J].ElectrochemistryCommunications,2012,24:93–96. 32.JichaoLiang,ChangzhengLiu,AijunQiao,YingCui2,,HuabingZhang,AnfangCui,ShutianZhang,YanliYang,,XinhuaXiao,YongChen,FudeFang,YongshengChang.MicroRNA-29a-cdecreasefastingbloodglucoselevelsbynegativelyregulatinghepaticgluconeogenesis[J].JournalofHepatology,2013,58:535–542. 33.Xiao-minChen,MinWei,Hai-mouZhang,Cheng-haoLuo,Yi-kunChen,YongChen.EffectofvanillinandethylvanillinonCytochromeP450activityinvitroandinvivo[J].FoodChemToxicol,2012,50(6):1897-1901 34.YiMingjing,PengWei,ChenXiaomin,WangJunjun,ChenYong.EffectofhypaconitinecombinedwithliquiritinontheexpressionofCalmodulinandConnexin43inratcardiacmuscleinvivoo[J].JournalofPharmacyandPharmacology.2012,64:1654–1658. 35.LIULi,XIAOJuan,PENGZhi-hong,WUWen-hua,DUPeng,CHENYong.InvitroMetabolismofStrychninebyHumanCytochromeP450andItsInteractionwithGlycyrrheticAcido[J].ChineseHerbalMedicines,2012,4(2):118-125.

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