余希岚 - 湖北大学 - 生命科学学院

个人简介

一、学习和工作简历 2001/09–2005/06，华中农业大学，生命科学技术学院生物技术专业，学士 2008/01–2013/05，美国爱荷华州立大学，遗传学，博士 2013/05–2014/05，美国爱荷华州立大学，微生物学，研究助理 2014/05–2015/05，美国斯托瓦斯医学研究所，生物化学，博士后 2015/09–至今，湖北大学，生命科学学院，讲师、副教授、教授二、承担科研项目情况 1.国家自然科学基金（31872812）：SAGA催化的Ada3乙酰化调控基因表达的机制研究；经费：72万元；2019.01-2022.12，主持人。 2.国家自然科学基金（31600046）：丁香假单胞菌海藻糖合成与抗水分胁迫相关性研究；经费：24万元；2017.01-2019.12，主持人。 3.湖北省自然科学基金“杰青”项目（2017CFA066）：二甲双胍抗肿瘤的表观遗传调控的机制研究；经费：20万元；2017.1-2019.12，主持人。 4.湖北省“青年百人计划”配套经费，2017.07-2020.07，主持人。 5.湖北省自然科学基金（2016CFB103）：丙酮酸激酶复合体（SESAME）对端粒异染色质形成以及细胞衰老的影响；经费：5万元；2016.01-2017.12，主持人。 6.美国国立卫生院基金（2008-35600-18786）：AnalysisofmetazoanSAGAcomplexfunctioningeneexpression；经费：120万美元；2012.01-2016.12，已结题，参与。 7.美国农业部基金（MCB-0920156）：FunctionalGenomicsoftheEpiphyticandPathogenicLifestylesoftheBacterialPlantPathogenPseudomonassyringae；经费：90万美元；2008.01-2012.12，已结题，参与。 8.美国国家自然科学基金（GM099945-01）：CellularresponsestoquaternaryammoniumcompoundsbyPseudomonassyringaethatinfluenceitsinteractionswithplants；经费：58万美元；2010.01-2012.12，已结题，参与。

研究领域

研究领域：表观遗传学、细胞代谢、细胞衰老、微生物遗传学

近期论文

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1.RuiMa#,YinshengWu#,YanshengZhai,BichengHu,WeiMa,WenqiangYang,QiYu,ZhenChen,JerryL.Workman,XilanYu*,ShanshanLi*.ExogenouspyruvaterepresseshistonegeneexpressionandinhibitscancercellproliferationviatheNAMPT-NAD+-SIRT1pathway,NucleicAcidsResearch,2019,47(21):11132-11150. 2.QianyunMei,ChenXu,GogolMadelaine,JieTang,WanpingChen,XilanYu,JerryL.Workman*,ShanshanLi*.Set1-catalyzedH3K4trimethylationantagonizestheHIR/Asf1/Rtt106repressorcomplextopromotehistonegeneexpressionandchronologicallifespan,NucleicAcidsResearch,2019,47(7):3434-3449. 3.XilanYu,StevenP.Lund,RussellA.Scott,JessicaW.Greenwald,AngelaH.Records,DanNettleton,StevenE.Lindow,DennisC.Gross,GwynA.Beattie*,TranscriptionalresponsesofPseudomonassyringaetogrowthinepiphyticversusapoplasticleafsites,ProcNatlAcadSciUSA,2013,110(5):E425-E434 4.XilanYu,LiS*,Non-metabolicfunctionsofglycolyticenzymesintumorigenesis,Oncogene,2017,36(19):2629-2636 5.XilanYu,StevenP.Lund,JessicaW.Greenwald,AngelaH.Records,RussellA.Scott,DanNettleton,StevenE.Lindow,DennisC.Gross,GwynA.Beattie*,TranscriptionalanalysisoftheglobalregulatorynetworksactiveinPseudomonassyringaeduringleafcolonization,mBio,2014,5(5):e01683-14 6.KebingWang#,ChengmingYang#,JiajunYe,FanqiZeng,YanlingDuan,YiZheng*,BoHu*,XilanYu*,Inhibitionactivityofherpesvirus(HSV)replicationbyα-TIFsiRNA-loadedPLGA-TPGSnanoparticlesinvitroandinvivo,JBiomedNanotechnol,2017,13(6):717-726 7.YinshengWu#,ShihaoZhang#,QiYu#,XuanyunjingGong#,MingdanLuo,YuanZhang,JerryL.Workman,XilanYu*,ShanshanLi*.GlycolysisregulatesgeneexpressionbypromotingthecrosstalkbetweenH3K4me3andH3K14acinSaccharomycescerevisiae,JGenetGenomics,2019,inpress. 8.XilanYu,RuiMa,YinshengWu,YanshengZhai,ShanshanLi*.ReciprocalRegulationofMetabolicReprogrammingandEpigeneticModificationsinCancer,FrontGenet,2018,9:394 9.QianyunMei#,JunhuaHuang#,WanpingChen,JieTang,ChenXu,QiYu,YingCheng,LixinMa,XilanYu*,ShanshanLi*,RegulationofDNAreplication-coupledhistonegeneexpression,Oncotarget,2017,8(55):95005-95022 10.QiYu#,ChongTong#,MingdanLuo,XiangyanXue,QianyunMei,LixinMa,XiaolanYu,WuxiangMao,LingbaoKong,XilanYu*,ShanshanLi*,ReuglationofSESAME-mediatedH3T11phosphorylationbyglycolyticenzymesandmetabolites,PLoSOne,2017,12(4):e0175576 11.XilanYu,MaoW,ZhaiY,TongC,LiuM,MaL,YuX,LiS.Anti-tumoractivityofmetformin:frommetabolicandepigeneticperspectives.Oncotarget.2017,doi:10.18632/oncotarget.13639 12.JamieO.Dyer#,ArnobDutta#,MadelaineGogol,VikkiM.Weake,GeorgeDialynas,XilanYu,ChristopherSeidel,YingZhang,LaurenceFlorens,MichaelP.Washburn,SusanM.Abmayr*,JerryL.Workman*,Myeloidleukemiafactorsactsinachaperonecomplextoregulatetranscriptionfactorstabilityandgeneexpression,JMolBiol,2017,429(13):2093-2107(IF=5.067) 13.ShanshanLi,XilanYu,GwynA.Beattie*,GlycinebetainecatabolismcontributestoPseudomonassyringaetolerancetohyperosmoticstressbyrelievingbetaine-mediatedsuppressionofcompatiblesolutesynthesis,JBacteriol,2013,195(10):2415-2423(IF=3.234) 14.FenglinGuo,XilanYu,AhuiXu,JingXu,QianruoWang,YunliGuo,XiaoyuWu,YuxinTang,ZhenDing,YanniZhang,TianGong,ZishuPan,ShanshanLi,LingbaoKong,JapaneseencephalitisvirusinducesapoptosisbyinhibitingFoxosignalingpathway,VetMicrobiol,2018,220:73-82(IF=2.791) 15.BrianC.Freeman,ChiliangChen,XilanYu,LindseyNielsen,KellyPeterson,GwynA.Beattie*,PhysiologicalandtranscriptionalresponsestoosmoticstressoftwoPseudomonassyringaestrainsthatdifferintheirepiphyticfitnessandosmotolerance,JBacteriol,2013,195(20):4742-4752(IF=3.234) 16.ShanshanLi,LingbaoKong,XilanYu,YiZheng.Host-virusinteractions:Fromtheperspectivesofepigenetics,RevMedVirol,2014,24(4):223-41(IF=3.702)