当前位置: X-MOL首页全球导师 国内导师 › 杨世辉

个人简介

学习和工作简历: 1989年9月-1993年7月,湖北大学生命科学系,获理学学士学位 1993年7月-1997年6月,湖北省襄樊市新药特药公司销售员及质检科科长 1997年9月-2000年7月,武汉大学生命科学学院,获理学硕士学位 2000年9月-2005年5月,加州大学河滨分校,获理学博士学位 2005年5月-2007年2月,威斯康星大学密尔沃基分校生物学系,博士后 2007年2月-2011年2月,美国能源部橡树岭国家实验室,副研究员(ResearchAssociate) 2011年2月-2016年,美国能源部国家可再生能源实验室,研究员(StaffScientist) 2016年-今,湖北大学生命科学学院教授 承担科研项目情况: 1.湖北省生物资源绿色转化协同创新中心启动经费(湖北省科技厅),400万,2016-2021,主持 2.NRELLDRD.SmallRNAandRiboswitches:ANewFrontierforBiofuelsStrainEngineering.2015-2017.EricKnoshaug(PI),ShihuiYang(Co-PI),andBryonDonohoe(Co-PI). 3.NRELLDRDSeedProject.2015.IntegratedApproachtoConnectGeneticProfileswithMicrostructuralPhenotypesInvolvedinBiofuelProductioninGreenAlgae.AlexandraDubini(PI),ShihuiYang(Co-PI),andPeterCiesielski(Co-PI). 4.DOEOfficeofScience,SystemsBiologyofBioenergy-RelevantMicrobestoEnableProductionofNext-GenerationBiofuels.2014.Unravellipidaccumulationmechanisminoleaginousyeastthroughsingle-cellsystemsbiologystudy.SunneyXie(PI),Shi-YouDing(Co-PI).ShihuiYang(Keypersonnelonsingle-celltranscriptomicdataanalysisandmetabolicengineering). 5.NRELLicenseRevenue-FundedProject.2013-2014.Geneticelementsandmicroorganismsconferringenhancedtolerancetopretreatedcornstoverhydrolysate.ShihuiYang(PI). 专利 1.Yang,S.,Linger,J.,Franden,A.,Pienkos,P.T.,andZhang,M.US14265039.Biocatalystswithenhancedinhibitortolerance. 2.Brown,S.,andYang,S.US20130078691.MicroorganismshavingenhancedresistancetoacetateandrelatedcompositionsandmethodsofUse. 3.Brown,S.,Guss,A.,Yang,S.,Karpinets,T.,andLynd,L.US20110287499.Nucleicacidmoleculesconferringenhancedethanoltoleranceandmicroorganismshavingenhancedtolerancetoethanol. 4.Brown,S.,andYang,S.US20100311137.Microorganismshavingenhancedtolerancetoinhibitorsandstress. 5.Yang,C.-H.,andYang,S.US20100249234andWIPOWO/2008/124836.Methodsofreducingvirulenceinbacteria. 获奖: 1.2015年12月美国国家可再生能源实验室项目贡献奖 2.2015年4月美国国家可再生能源实验室月度员工奖 3.2009年11月橡树岭国家实验室生物科学部研究助理卓越成就奖(1年1个) 4.2003年加州大学河滨分校克劳资纪念奖 5.2002年加州大学河滨分校詹姆斯和艾德琳华莱士年度奖(1年1个) 6.2000年-2005年加州大学河滨分校校长卓越奖学金

研究领域

主要研究领域:分子微生物学,代谢工程,功能基因组学和生物信息学,合成生物学,系统生物学,生物能源、生物防治及微生物-宿主相互作用

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

代表性论文(通讯作者#与共同第一作者*文章:24,共40篇;总引用>1000,H-因子:18): EthanologenicZymomonasmobilis: 1.Yang,S.*#,Fei.,Q.*,Zhang,Y.,Contreras,L.M.,Utturkar,S.M.,Brown,S.D.,Himmel,M.E.,andZhang,M#.2016.Zymomonasmobilisasamodelsystemforproductionofbiofuelsandbiochemicals.MicrobialBiotechnology(InPress). 2.Yang,S.#,Mohagheghi,A.,Franden,A.,Chou,Y-C.,Dowe,N.,Himmel,M.E.,andZhang,M#.2016.MetabolicengineeringofZymomonasmobilisfor2,3-butanediolproductionfromlignocellulosicbiomasssugars.BiotechnolBiofuels9:189. 3.Yang,S.#,Franden,A.,Chou,Y-C.,Brown,S.D.,Pienkos,P.T.,andZhang,M#.2014.InsightsintoacetatetoxicityinZymomonasmobilis8busingdifferentsubstrates.BiotechnolBiofuels7:140. 4.Yang,S.#,Pan,C.,Hurst,G.B.,Dice,L.,Davison,B.H.,andBrown,S.D.#.2014.ElucidationofZymomonasmobilisphysiologyandstressresponsestoacetatebyquantitativeproteomicsandtranscriptomics.Front.Microbiol.5:246.doi:10.3389/fmicb.2014.00246. 5.Yang,S.,Pan,C.,Tschaplinski,T.J.,Hurst,G.B.Engle,N.L.,Zhou,W.,Dam,P.,Xu,Y.,Rodriguez,M.Jr.,Dice,L.,Johnson,C.M.,Davison,B.H.,andBrown,S.D.2013.SystemsbiologyanalysisofZymomonasmobilisZM4ethanolstressresponses.PLoSONE8(7):e68886. 6.Yang,S.,Land,M.L.,Klingeman,D.M.,Pelletier,D.A.,Lu,S.T.,Martin,S.L.,Guo,H.B.,Smith,J.C.,andBrown,S.D.2010.ParadigmforindustrialstrainimprovementidentifiessodiumacetatetolerancelociinZymomonasmobilisandSaccharomycescerevisiae.Proc.Natl.Acad.Sci.USA.107:10395–10400. Facultyof1000recommended:http://ec2-176-34-150-24.eu-west-1.compute.amazonaws.com/prime/10030959 7.Yang,S.,Pelletier,D.A.,Lu,S.T,andBrown,S.D.2010.TheZymomonasmobilisregulatorHfqandrelatedSaccharomycescerevisiaeproteinscontributetotoleranceagainstmultiplelignocellulosicpretreatmentinhibitors.BMCMicrobiol.10:135. 8.Yang,S.,Pappas,K.M.,Hauser,L.J.,Land,M.L.,Chen,G-L,Hurst,G.B.etal.2009.ImprovedgenomeannotationforZymomonasmobilis.Nat.Biotechnol.27:893–4. 9.Yang,S.,Tschaplinski,T.J.,Engle,N.L.,Carroll,S.L.,Martin,S.L.,Davison,B.H.,Palumbo,A.V.,Rodriguez,M.Jr.,andBrown,D.,S.2009.TranscriptomicandmetabolomicprofilingofZymomonasmobilisduringaerobicandanaerobicfermentation.BMCGenomics10:34.(Highlyaccessed). ThermophilicClostridiumthermocellum: 10.Xu,Q.,Resch,M.,Podkaminer,K.,Yang,S.,Baker,J.,Donohoe,B.,Wilson,C.,Klingeman,D.M.,Olson,D.,Decker,S.,Giannone,R.J.,Hettich,R.L.,Brown,S.D.,Lynd,L.R.,Bayer,E.A.,Himmel,M.E.,andBomble,Y.2016.DramaticperformanceofClostridiumthermocellumexplainedbyitswiderangeofcellulasemodalities.ScienceAdvances.2(2):e1501254. 11.Wilson,C.M.*,Yang,S.*,Rodriguez,M.Jr.,Ma,Q.,Johnson,C.M.,Dice,L.,Xu,Y.,andBrown,S.D.2013.Clostridiumthermocellumtranscriptomicprofilesafterexposuretofurfuralorheatstress.BiotechnolBiofuels6:131. 12.Yang,S.,Giannone,R.J.,Dice,L.,Yang,Z.K.,Engle,N.L.,Tschaplinski,T.J.,Hettich,R.L.,andBrown,S.D.2012.ClostridiumthermocellumATCC27405transcriptomic,metabolomicandproteomicprofilesafterethanolstress.BMCGenomics13:336. 13.Brown,S.D.,Guss,A.M.,Karpinets,T.V.,Parks,J.M.,Smolin,N.,Yang,S.,Land,M.L.,etal.2011.MutantalcoholdehydrogenaseleadstoimprovedethanoltoleranceinClostridiumthermocellum.Proc.Natl.Acad.Sci.USA.108:13752-7. 14.Wei,H.,Fu,Y.,Magnusson,L.,Baker,JO.,Maness,PC.,Xu,Q.,Yang,S.,Bowersox,A.,Bogorad,I.,Wang,W.,Tucker,MP.,Himmel,ME.,Ding,S.2014.ComparisonoftranscriptionalprofilesofClostridiumthermocellumgrownoncellobioseandpretreatedyellowpoplarusingRNA-Seq.Front.Microbiol.5:142. MolecularMicrobe-PlantInteractions: 15.Yang,S.,Peng,Q.,Zhang,Q.,Zou,L.,Li,Y.,Robert,C.etal.2010.Genome-wideidentificationofHrpL-regulatedgenesinnecrotrophicphytopathogenDickeyadadantii3937.PLoSONE5(10):e13472. 16.Yang,S.*,Peng,Q.*,SanFrancisco,M.,Wang,Y.,Zeng,Q.,andYang,C.-H.2008.TypeIIIsecretionsystemgenesofDickeyadadantii3937areinducedbyplantphenolicacids.PLoSONE3(8):e2973. 17.Yang,S.,Zhang,Q.,Peng,Q.,Yi,X.,Chang,J.C.,Reedy,R.M.,Charkowski,A.O.,andYang,C.-H.2008.DynamicregulationofGacAintypeIIIsecretionsystem,pectinasegeneexpression,pellicleformation,andpathogenicityofDickeyadadantii.Mol.Plant-MicrobeInteract.21:133-142. 18.Yang,S.,Zhang,Q.,Guo,J.,Charkowski,A.O.,Glick,B.R.,Ibekwe,A.M.,Cooksey,D.A.,andYang,C.-H.2007.Globaleffectofindole-3-aceticacid(IAA)biosynthesisonmultiplevirulencefactorsofErwiniachrysanthemi3937.Appl.Env.Microbiol.73:1079-1088. 19.Peng,Q.*,Yang,S.*,Charkowski,A.O.,Yap,M.N.,Steeber,D.A.,Keen,N.T.,andYang,C.-H.2006.PopulationbehavioranalysisofdspEandpelDexpressioninErwiniachrysanthemi3937.Mol.Plant-MicrobeInteract.19:451-7. 20.Yang,S.,Perna,N.T.,Cooksey,D.A.,Okinaka,Y.,Lindow,S.E.,Ibekwe,A.M.,Keen,N.T.,andYang,C-H.2004.Genome-wideidentificationofplant-upregulatedgenesofErwiniachrysanthemi3937usingaGFP-basedIVETleafarray.Mol.Plant-MicrobeInteract.17:999-1008. Others(Lignin,Systemsbiology,Meta-transcriptomics,andBioinformaticsetc.): 21.Yang,S#Wang,W.#,Wei,H.,Wychen,S.V.,Pienkos,P.T.,Zhang,M.,andHimmel,M.2016.Impactofnitrogendeficiencystrategiesonlipidproductionforyeastandfungalspecies.Energies.9:685. 22.Wang,W*#.,Yang,S.*#,Pienkos,P.T.,andJohnson,D.2014.Connectinglignin-degradationpathwaywithpretreatmentinhibitorsensitivityofCupriavidusnecator.Front.Microbiol.5:247. 23.Zeng,Y.,Zhao,S.,Yang,S.,andDing,S.2014.Ligninplaysthenegativeroleinthebiochemicalprocessforproducinglignocellulosicbiofuels.Curr.Opin.Biotechnol.27:38-45. 24.Yang,S.#,Guarnieri,M.T.,Smolinski,S.,Ghirardi,M.,andPienkos,P.T.2013.DenovotranscriptomicanalysisofhydrogenproductioninthegreenalgaChlamydomonasmoewusiithroughRNA-Seq.BiotechnolBiofuels6:118. 25.Chou,W-C.,Ma,Q.,Yang,S.,Cao,S.,Brown,S.D.,andXu,Y.2015.Analysisofstrand-specificRNA-seqdatausingmachinelearningrevealsthestructuresoftranscriptionunitsinClostridiumthermocellum.NucleicAcidsRes.doi:10.1093/nar/gkv177. 26.Guarnieri,M.T.,Nag,A.,Yang,S.,andPienkos,P.T.2013.ProteomicanalysisofChlorellavulgaris:Potentialtargetsforenhancedlipidaccumulation.JProteomics.pii:S1874-3919(13)00278-9.

推荐链接
down
wechat
bug