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个人简介

一、学习和工作简历: 2000-2006Ph.D.TheOhioStateUniversity,USA 2006-2010Postdoc.NIH(NationalHeart,Lung,andBloodInstitute)USA 2010-AssistantProfessor(tenure-track) BloombergSchoolofPublicHealth,JohnsHopkinsUniversity,USA 二、主持的代表性科研项目 1.R01,NIH/NIEHSUSA,04/01/16-03/31/21 Exposure-alteredgeneexpressioninfivecandidateimprintedlociforadultdisease 2.U01,NIEHSUSA,07/01/16-06/30/21 EpigenomicsofAirPollutiondrivenInflammation,ObesityandInsulinResistance 3.KimmelScholarAward,TheSidneyKimmelFoundationforCancerResearch,USA 07/01/2012-06/30/2014 AbnormalepigeneticcodesmediatedbyDNMT1andMi-2/NuRDcomplexincancercells

研究领域

研究领域:环境表观遗传学

近期论文

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1.Li,Z.,*Dai,H.,Martos,SN,Xu,B.,Gao,Y,Zhu,G.,Li,T.,Schones,D.E.,andWang,Z.(2015)DistinctrolesofDNMT1-dependentand–independentmethylationpatternsinthegenomeofmouseembryonicstemcells.GenomeBiologyDOI:10.1186/s13059-015-0685-2(Impactfactor10.8) 2.2.Martos,S.N.,Tang,W.,andWang,Z.(2015)Elusiveinheritance:Transgenerationaleffectsandepigeneticinheritanceinhumanenvironmentaldisease.ProgressinBiophysicsandMolecularBiology(impactfactor3.5) 3.Jin,Q.,Zhuang,L.,Lai,B.,Wang,C.,Li,W.,Dolan,B.,Wang,Z.,Zhao,K.,Peng,W.,Dent,S.,andGe,K.(2014)Gcn5andPCAFnegativelyregulateinterferonproductionthroughHAT-independentinhibition.EMBOReport(11):1192-201(Impactfactor7.858) 4.Dai,H.,andWang,Z.(2014)Histonemodificationpatternsandtheirresponsestoenvironment.CurrentEnvironmentalHealthReports1:11-21(Invitedreview) 5.Wu,H.,D'Alessio,A.C.D.,Ito,S.,Wang,Z.,Cui,K.,Zhao,K.,Sun,Y.E.,andZhang,Y.(2011)Genome-wideanalysisof5-hydroxymethylcytosinedistributionrevealsitsdualfunctionintranscriptionalregulationinmouseembryonicstemcells.Genes&Development25:679-684(231citations)(impactfactor12.44) 6.*Wu,H.,*D'Alessio,A.C.D.,Ito,S.,Xia,K.,Wang,Z.,Cui,K.,Zhao,K.,Sun,Y.E.,andZhang,Y.(2011)DualfunctionsofTet1intranscriptionalregulationinmouseembryonicstemcells.Nature473,389-393(*Contributeequally)(294citations)(impactfactor37.162) 7.Daniel,J.A.,*Santos,M.A.,*Wang,Z.,*Zang,C.,Jankovic,M.,Gazumyan,A.,KristopherR.Schwab,K.R.,Yamane,A.,Filsuf,D.,Cho,Y-W.,Ge,K.,Nussenzweig,M.C.,asellas,R.,Dressler,G.R.,Zhao,K.,andNussenzweig,A.(2010)PTIPpromoteschromatinchangescriticalforimmunoglobulinswitchrecombination.Science329,917-923(*Co-secondauthor)(70citations)(impactfactor31.027) 8.Qi,H.H.,Sarkissian,M.,*Hu,G-q.,*Wang,Z.,Bhattacharjee,A.,Gordon,D.B.,Lan,F.,Ongusaha,P.P.,Huarte,M.,Yaghi,N.K.,Lim,H.,Garcia,B.A.,Brizuela,L.,Zhao,K.,Roberts,T.M.,andShi,Y.(2010)HistoneH3K9/H4K20demethylasePHF8regulateszebrafishbrainandcraniofacialdevelopment.Nature466,503-507(Theseauthorscontributeequally;*TheseauthorscontributeequallytoChIP-seq)(119citations)(impactfactor37.162) 9.Zhou,J.,Wang,C.,Wang,Z.,Dampier,W.,Wu,K.,Casimiro,M.C.,Yu,Z.,Wang,M.,Liang,B.,Chepelev,L.,Popov,V.M.,Sune,C.,Quong,A.,Lisanti,M.P.,Tozeren,A.,Zhao,K.,andPestell,R.G.(2010)AttenuationofforkheadsignalingbytheretinaldeterminationfactorDACH1.ProcNatlAcadSciUSA107,6864-6869(impactfactor9.737) 10.Wang,Z.,Zang,C.,Cui,K.,Schones,D.E.,Barski,A.,Peng,W.,Zhao,K.(2009b)Genome-widemappingofHATsandHDACsrevealsdistinctfunctionsinactiveandinactivegenes.Cell138,1019-1031(impactfactor31.975)(611citations) 11.*Araki,Y.,*Wang,Z.,Zang,C.,Wood,W.III.,Schones,D.E.,Lhotsky,B.,Westo,R.,Peng,W.,Becker,K.,Zhao,K.,andWeng,N-p.(2009)Genome-wideanalysisofhistonemethylationrevealschromatinstate-basedcomplexregulationofgenetranscriptionandfunctionofmemoryCD8+Tcells.Immunity30,912-925(*co-firstauthor)(impactfactor19.795) 12.Wang,Z.,Schones,D.E.andZhao,K.(2009a)Characterizationofhumanepigenomes.CurrentOpinioninGeneticsandDevelopment19,127-134(impactfactor8.23) 13.Rosenfeld,J.A.,Wang,Z.,Schones,D.E.,DeSalle,R.,Zhao,K.,Zhang,M.(2009)Determinationofenrichedhistonemodificationsinnon-genicportionsofthehumangenome.BMCGenomicsdoi:10.1186/1471-2164/10/143(121citations)(impactfactor4.40) 14.Wang,Z.,Zang,C.,Rosenfeld,J.A.,Schones,D.E.,Barski,A.,Cuddapah,S.,Cui,K.,Roh,T-y,Peng,W.,Zhang,M.,Zhao,K.(2008).Combinatorialpatternsofhistoneacetylationsandmethylationsinthehumangenome.NatureGenetics40,897-903(impactfactor35.209)(1168citations) 15.*Schones,D.E.,*Cui,K.,Cuddapah,S.,Roh,T-y,Barski,A.,Wang,Z.,Wei,G.,Zhao,K.(2008)Dynamicregulationofnucleosomepositioninginthehumangenome.Cell132,887-898(*contributeequally)(impactfactor31.975)(811citations) 16.Barski,A.,Cuddapah,S.,Cui,K.,Roh,T-y,Schones,D.E.,Wang,Z.,Wei,G.,Chepelev,I.,Zhao,K.(2007)Response:MappingnucleosomepositionsusingChIP-Seqdata.Cell131,832-833(impactfactor31.975) 17.*Barski,A.,*Cuddapah,S.,*Cui,K.,*Roh,T-y,*Schones,D.E.,*Wang,Z.,*Wei,G.,Chepelev,I.,Zhao,K.(2007)High-resolutionprofilingofhistonemethylationsinthehumangenome.Cell129,823-837(*Contributeequallyandarelistedalphabetically)(Featuredarticle)(impactfactor31.975)(TheNo.3most-citedbiologypaperof2009byTheScientist)(4067citations)

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