个人简介
学习和工作简历:
1997年武汉同济医科大学医学博士学位
1996年北京病毒基因工程国家重点实验室(侯云德院士)研究工作
1997年中国科学院上海生物化学研究所(李载平院士)研究工作
1998年美国波士顿大学博士后研究工作
2001年美国哈佛大学医学院博士后研究工作
2002年美国哈佛大学医学院研究员
2007年湖北大学生命科学学院教授,博士生导师
1997年中国科学技术协会自然科学论文优秀奖
2006年武汉理工大学湖北省生物材料工程技术研究中心兼职教授
2007年湖北省中药生物技术重点实验室学术委员会学术委员
2007年湖北省工业生物技术重点实验室副主任
2007年湖北省工业生物技术重点实验室学术委员会学术委员
科研项目
1.国家自然科学基金面上项目(31070776)
C5a受体介导血管内皮细胞损伤机制的研究,2011.1-2013.12,主持人
2.国家自然科学基金面上项目(30972769)
补体调节蛋白质C1抑制物的新功能研究,2010.1-2012.12,主持人
3.国家自然科学基金国家合作项目(30811130467/C0302)
蛋白水解酶系统作为癌症标记和癌症治疗的靶标,2008.9-2011.8,主要参与人
4.国家教育部回国留学基金(30811130467/C0302)
补体调节蛋白质C1抑制物的研究,2008.9-2011.8,主持人
5.美国国立卫生研究院基金NIH-R01(2005-2010)
C1Inhibitorpreventsendotoxinshock,主要参与人
6.美国国立卫生研究院基金NIH-PhaseI(2010-2011)
Peptidesfrompreventingsepsis,C1主要参与人
专利申请
1.刘东旭人源胰岛素样生长因子结合蛋白1在毕氏酵母中的诱导表达及纯化方法、相关抗体制备和应用201210531593.5
2.刘东旭抗内毒素短肽在毕氏酵母中的诱导表达方法、表达的抗内毒素短肽及应用201010585889.6
3.刘东旭正常人和哺乳动物不同组织源性原代细胞分离的多酶体系、其用途和相关试剂盒201010228374.0
4.刘东旭病人肿瘤组织源性原代细胞分离的多酶体系、其使用方法、用途和相关试剂盒201010254756.0
5.刘东旭自发性免疫性疾病特异性抗体和相关的自发性免疫性疾病诊断试剂盒
201010169506.7
6.雷震、刘东旭一种细胞长期培养保存三维系统及相关的细胞长期培养保存方法200910194729
7.DavisAEIIIandLiuDMethodsfortreatingandpreventingsepsisusingmodifiedC1InhibitororfragmentsthereofUS2005288218
近期论文
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1.LiuM,XieM,JiangS,LiuG,LiL,LiuD,YangX.(2014)AnovelbispecificantibodytargetingtumornecrosisfactorαandED-Bfibronectineffectivelyinhibitstheprogressionofestablishedcollagen-inducearthritis.JBiotechnol.186:1.
2.YangX,LiuM,ZhangH,XueB,ShiH,LiuD.(2014)ProteinkinaseC-δMediatesSepsis-inducedActivationofComplement5aandUrokinase-typePlasminogenActivatorSignalinginMacrophages.InflammationResearch.63:581.
3.YangX,WangX,LiuD,YuL,XueB,ShiH.(2014)EpigeneticRegulationofMacrophagePolarizationbyDNAMethyltransferase3b.MolEndocrinol.28:565.
4.LiuM,HuangY,HuL,LiuG,HuX,LiuD,YangX.(2012)Selectivedeliveryofinterleukine-1receptorantagonisttoinflamedjointbyalbuminfusion.BMCBiotechnol.12:68.
5.LiuL,QinXJ,LiuM,ZhangHM,ChengZD,andLiuD*.(2010)SilencingofC5areceptorgenewithsiRNAforprotectionfromGram-negativebacteriallipopolysaccharide-inducedvascularpermeability.MolecularImmunology.47:1325.
6.HuaD,LiuMY,ChengZD,QinXJ,ZhangHM,ChenY,QinGJ,LiangG,LiJN,HanXF,andLiuD*.(2009)SmallinterferingRNA-directedtargetingofToll-likereceptor4inhibitshumanprostatecancercellinvasion,survival,andtumorigenicity.MolecularImmunology.46:2876.
7.ZhouJ,ZhuY,ChengM,DineshD,ThorneT,PohKK,LiuD,BotrosC,TangYL,ReisdorphN,KishoreR,LosordoDW,QinG.(2009)RegulationofvascularcontractilityandbloodpressurebytheE2F2transcriptionfactor.Circulation.120:1213.
8.ChengZ,LiuM,ChenG,ZhangH,QinG,LiangG,andLiuD*.(2008)Anti-vascularpermeabilityofthecleavedreactivecenterloopwithinthecarboxyl-terminaldomainofC1inhibitor.MolecularImmunology.45:1743.
9.DavisAEIII,CaiS,andLiuD*.(2007)C1inhibitor:biologicactivitiesthatareindependentofproteaseinhibition.Immunobiology.212:313.
10.WuY,TuX,LinG*,XiaH,HuangH,WanJ,FuJ,LiuQ,LiangQ,QinG,ZhangH,ZhangH,andLiuD*.(2007)Emodin-mediatedprotectionfromacutemyocardialinfarctioninmiceviainhibitinginflammationandapoptosisinlocalischemicmyocardium.LifeSciences.LifeSciences.81:1332.
11.LiuD*,QinG,FernandesSM,LiJ,andDavisIIIAE*.(2007)C1Inhibitor-MediatedProtectionfromSepsis.TheJournalofImmunology.TheJournalofImmunology.TheJournalofImmunology.179:3966.
12.ZhangH,LiJ,BarringtonRA,LiangG,QinG,andLiuD*.(2007)Ananti-endotoxinpeptidethatgeneratesfromtheamino-terminaldomainofcomplementregulatoryproteinC1inhibitor.BiochemicalandBiophysicalResearchCommunication.359:285.
13.ZhangH,QinG,LiangG,LiJ,BarringtonRA,andLiuD*.(2007)SuppressionofcomplementregulatoryproteinC1inhibitorinvascularendothelialactivationbyinhibitingvascularcelladhesionmolecule-1action.BiochemicalandBiophysicalResearchCommunication.358:1120.
14.ZhangH,QinG,LiangG,LiJ,BarringtonRA,andLiuD*.(2007)C5aR-mediatedmyocardialischemia/reperfusioninjury.BiochemicalandBiophysicalResearchCommunication.357:446.
15.FuJ,LinG*,ZengB,WuZ,WuY,ChuH,QinG,LiangG,LiJ,GanX,YuX,LiC,andLiuD*.(2006)Anti-ischemia/reoxygenationofC1inhibitorinmyocardialcellinjuryviaregulationoflocalmyocardialC3activity.BiochemicalandBiophysicalResearchCommunication.350:162.
16.FuJ,LinG*,XiangY,WuZ,CengB,WuY,LiangG,QinG,LiJ,ChiuI,andLiuD*.(2006)Anti-apoptoticroleforC1inhibitorinischemia/reperfusion-inducedmyocardialcellinjury.BiochemicalandBiophysicalResearchCommunication.349:504.
17.LiuD,CramerCC,ScafidiJ,andDavisAEIII(2005).N-linkedglycosylationAsn3andthepositivelychargedaminoacidswithintheaminoterminaldomainofC1inhibitorarerequiredforitsinteractionofC1inhibitorwithSalmonellaentericaSerovarTyphimuriumlipopolysaccharideandlipidA.InfectionandImmunity.73:4478.
18.LiuD,ZhangD,ScafidiJ,CramerCC,WuX,andDavisAEIII.(2005)C1inhibitorprotectsfromlipopolysaccharide-inducedvascularpermeability.Blood.105:2350.
19.DavisAEIII,CaiS.andLiuD(2004)ThebiologicroleofC1inhibitorinregulationofvascularpermeabilityandmodulationofinflammation.AdvancesinImmunology.82:331.
20.LiuD,GuX,ScafidiJ,andDavisAEIII.(2004)N-linkedglycosylationisrequiredforC1inhibitor-mediatedprotectionfromendotoxinshockinmice.InfectionandImmunity.74:1946.
21.LiuD,CaiS,GuX,ScafidiJ,WuX,andDavisAEIII.(2003)C1Inhibitorpreventsendotoxinshockviaadirectinteractionwithlipopolysaccharide.TheJournalofImmunology,171:2594.
22.LiuD,ScafidiJ,PradaAE,ZahediK,andDavisAEIII.(2002)NuclearphosphatasesandtheproteasomeinsuppressionofSTAT1activityinhepatocytes.BiochemicalandBiophysicalResearchCommunication.299:574.
23.LiuDandWaxmanDJ.(2002)PosttranscriptionalregulationofhepaticNADPH-P450reductasebythyroidhormone:independenteffectonPoly(A)taillengthandmRNAstability.MolecularPharmacology.61:108.
24.LiH,LiuD,andWaxmanDJ.(2001)TranscriptionalinductionofhepaticP450reductasebythyroidhormone.MolecularPharmacology.59:987.
25.GuoT,ZhangY,LiuDetal.(1999)DauricineinhibitsredistributionofplateletmembraneglycoproteinIVandreleaseofintracellulara-granulethrombospondininducedbythrombin.ActaPharmacologicaSinica.20:533.
26.LiuD,ShenDi,ZouPetal.(1997)RedistributionofplateletmembraneglycoproteinIV(CD36)andreleaseofintracellulara-granularthrombospondininpatientswithchronicmyelogenousleukemia,JournalofTongjiMedicalUniversity.17:21.
27.LiuD,PengD,ChenRetal.(1995)Chronicpulmonaryinfectioncausedbymycoplasmapneumoniaeleadingtopulmonaryarterioleremodelingandpulmonaryhypertensioninrats.JournalofTongjiMedicalUniversity.15:223.
28.张彦周、刘东旭、李欲舒等.(1998)蝙蝠葛碱对二尖瓣狭窄患者血小板糖蛋白IV再分布的影响.中国中西医结合杂志.18:461.
29.刘东旭、尹华丽、郭涛等.(1998).人血小板生成素cDNA转染COS-7细胞表达产物对小鼠巨核胞的作用.中国免疫学杂志.14:172.
30.刘东旭、郭涛、沈迪.(1998).血清病及其类似症.内科免疫学(临床医学免疫学丛书),沈迪和邹萍主编.第一版,375-381.湖北科学技术出版社.1998.12.湖北武汉430077(ISBN7-5352-2126-2/R.408).(该丛书列为国家九五重点图书出版规划项目和全国高新技术丛书).
31.刘东旭、尹华丽、吴小林等.(1997)人血小板生成素转染及表达产物对实验性血小板减少症的治疗作用.中华医学杂志.77:834.
32.刘东旭、沈迪、魏文宁等.(1997)血小板膜糖蛋白IV再分布的研究.中华血液学杂志.18:323.
33.刘东旭、沈迪.(1997)Fas蛋白的基础和临床.《国外医学》病理生理学和临床医学分册,17:212.
34.刘东旭、沈迪.(1996)输血感染性疾病的检测.JAMA(中文版).15:133.
35.刘东旭、沈迪.(1996)血小板膜糖蛋白IV的基础与临床.《国外医学》分子生物学分册.18:64.
36.刘东旭、沈迪、邹萍等.(1996)重组人血小板生成素对巨核细胞-血小板作用的研究.中国免疫学志.13(suppl.):32.
37.刘东旭、彭东信、陈茹等.(1996)长期反复肺炎支原体肺炎感染致肺间质纤维化病理学研究.同济医科大学报.25:154.
38.刘东旭、彭东信、车东媛等.(1995)肺炎支原体肺炎动物模型的建立和病理学变化的特征.同济科大学学报.24:121.
39.刘东旭、沈迪.(1995).血小板糖蛋白IIa/IIIb复合物分子生物学研究.《国外医学》分子生物学分册.17:231.
40.刘东旭、彭东信.(1994).肺炎支原体肺炎检测的进展.《国外医学》内科学分册.21:50.