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个人简介

湖北省高层次人才,武汉东湖高新“3551”光谷青年人才。利用先进的技术手段研究T-ALL 白血病的形成、维持机制及肿瘤免疫治疗新技术的开发及产业转化。主持国自然科学基金和湖北省重大专项等基金10项。截至目前以第一作者或通讯作者发表包括Cell metabolism , Journal of Hematology & Oncology,Nature Communication,autophagy,elife,等论文20篇,单篇最高引用500多次,授权专利10项,完成或参与产业转化项目3项。 教育背景 2014.09-2019.07 北京大学前沿交叉研究院整合生物学博士 2010.09-2013.07 湖北大学生命科学学院生物化学硕士 2006.09-2010.07 武昌理工学院生物工程学士 主要荣誉 湖北省楚天学子2020 湖北省东湖高新技术开发区3551青年人才2021

研究领域

血液肿瘤的发生、发展及靶向治疗 血液肿瘤耐药机制研究 细胞治疗过程中的免疫细胞功能重编程

近期论文

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Long Chen#, Anqi Ren#, Hangyu Chen, Qifang Wu, Yuan Zhao, Zijian zhang, Tongcun Zhang, Wu Zhong*, Jian Lin*, Haichuan Zhu*,Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL,J Hematol Oncol,2023,Accept. Zhijie Zhang#, JiangzhouShi#, Qifang Wu, Zijian Zhang, Xiaoyan Liu, Anqi Ren, GuanlinZhao, Ge Dong, HanWu, Jiaxuan Zhao,Yuan Zhao1, Jia Hu,HuiLi,Tongcun Zhang*, Fuling Zhou*, Haichuan Zhu*. JUN mediates Glucocorticoid Resistance by stabilizing HIF1a in T-Cell Acute Lymphoblastic Leukemia.2023,iScience. Zijian Zhang,Qifang Wu,Anqi Ren,Qian Chen,Jiangzhou Shi,Jiapeng Li,Xiyu Liu,Zhijie Zhang,Yuzhe Tang,Yuan Zhao,Ningning Yao,Xiaoyu Zhang,Changpeng Liu,Ge Dong,Jiaxuan Zhao,Meijun Xu,Yunqiang Yue,Jia Hu,Fan Sun,Yu Liu,Qilin Ao,Fuling Zhou,Hong Wu,Tongcun Zhang*,Haichuan Zhu* .ATF4 renders human T-cell acute lymphoblastic leukemia cell resistanceto FGFR1 inhibitors through amino acid metabolic reprogramming."Acta Pharmacologica Sinica(2023): 1-14. Jie Chen#, Jinxin Yan#, Jiangzhou Shi#, Ying Liu, Yuzhe Li, Lina Zhao, Yinglin Zhou, Tongcun Zhang, Qiangfeng Cliff Zhang, Xinxiang Zhang*, HaichuanZhu*, Peng Jiang*. Upregulation of fumarate hydrase is critical for CD8+ T cell activation and enhances CAR T cell antitumour efficacy, Cell Metabolism,2023,35,1-18. .Anqi Ren#,Xiqin Tong#,Na Xu,Tongcun Zhang,Fuling Zhou*,Haichuan Zhu*.(2023). CAR T-Cell Immunotherapy Treating T-ALL: Challenges and Opportunities.Vaccines,11(1), 165. Ren, Anqi#, Yuan Zhao#, and Haichuan Zhu*. "T-ALL Cells as Tool Cells for CAR T Therapy."Vaccines11.4 (2023): 854. Shangkun Zhang#, Chaojiang Gu#, Lifang Huang#, Han Wu#, Jiangzhou Si, Zijian Zhang, Yong Zhou, Jingjiao Zhou, Yang Gao, Jiaxing Liu; Yingqi Leng, Xiyu Liu,Qinxing Zhang, Liang Huang, Xiqin Tong, Ken H. Young; Jiapeng Li; Haichuan Zhu*;Tongcun Zhang*. The third-generation anti-CD30 CAR T-cells specifically homing to the tumor and mediating powerful antitumor activity. Scientific reports, 2022, 12.1: 1-12. HaichuanZhu#,BingjieDong# ,YingchiZhang#,MeiWang,JiananRao,BowenCui,YuLiu,QianJiang,WeitaoWang,LuYang,AnqiYu,ZongruLi,ChaoLiu,LepingZhang,XiaojunHuang*,XiaofanZhu*,HongWu*, Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia.Blood Science, 2022, 4.1: 16-28. Jiangzhou Shi#, Zijian Zhang#, Hong Cen#, Han Wu, Shangkun Zhang, Jiaxing Liu, Yingqi Leng, Anqi Ren, Xiyu Liu, Zhijie Zhang, Xiqin Tong, Jinjue Liang, Zhe Li, Fuling Zhou, Liang Huang, You Qin, Kunyu Yang, Tongcun Zhang*, Haichuan Zhu*. CAR T cells targeting CD99 as an approach to eradicate T-cell acute lymphoblastic leukemia without normal blood cells toxicity.J Hematol Oncol14,162 (2021). Hang yu Chen#; Xiao Xiao LI#; Chao Li#; Hai chuan Zhu#; Li feng Chen#; Jun Chen; Hong yan Hou; BoZhang; Li ming Cheng; Hui Hu; Zhong xin Lu; Jia xing Liu; Ze ruo Yang; Lei Zhang; Nuo Xu; Long Chen; Chuan He; Chao ran Dong*; Qing gang Ge*; Jian Lin*.CHEN, Hang-yu, et al. 5-Hydroxymethylcytosine Signatures in Circulating Cell-Free DNA as Early Warning Biomarkers for COVID-19 Progression and Myocardial Injury.Frontiers in cell and developmental biology, 2021, 9. Lu Yang#, Fenglin Chen#, Haichuan Zhu#, Yang Chen, Bingjie Dong, Minglei Shi, Weitao Wang, QianJiang, Leping Zhang, Xiaojun Huang*, Michael Qi Zhang*, Hong Wu*, 3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia.Nature Communications,2021,12(1), 1-12. Yilin Wu#, Haichuan Zhu#, Hong Wu*, PTEN in Regulating Hemato-poiesis andLeukemogenesis. Cold Spring Harbor perspectives in medicine.2019:a036244. Haichuan Zhu,Liuzhen Zhang, Yilin Wu, Bingjie Dong, Weilong Guo, Mei Wang, Lu Yang, Xiaoying Fan, Yuliang Tang, Ningshu Liu, Xiaoguang Lei, Hong Wu*, T-ALL leukemia stem cell'stemness' is epigenetically controlled by the master regulator SPI1. Elife. 2018;7:e38314). Wu Zhong#, Haichuan Zhu#,Fugeng Sheng, Yonglu Tian, Jun Zhou, Yingyu Chen, Song Li*, Jian Lin*, Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells. Autophagy. 2014;10(7):1285-300. Hongtao Shen #, Haichuan Zhu#, Mowei Song, Yonglu Tian, Yafei Huang, Hui Zheng, Ruiyuan Cao, Jian Lin, Zhenggang Bi*, Wu Zhong*, A selenosemicar-bazone complex with copper efficiently down-regulates the90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells. BMC cancer. 2014 ;14 (1):629. Qifang Wu #, Jiaxing Liu#, Zhijie Zhang, Anqi Ren, Xiyu Liu, Leyuan Bao*, Tongcun Zhang*, and Haichuan Zhu*. Salmon-Easy: An alignment-free RNA-seq quantitative strategy based on partial genome indexing. In:2022 14th International Conference on Bioinformatics and Biomedical Technology. 2022. p. 55-64.

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