张书宇 - 上海交通大学 - 化学化工学院

研究领域

1）以非活泼sp3C-H键活化反应为核心的天然产物及活性药物分子的全合成； 2）涉及多种化学键构建的非活泼sp3C-H键活化新反应的研究； 3）与化学生物学相结合的化学反应方法及仿生合成研究。

近期论文

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S.-Y. Zhang, Q. Li, G. He, W. A. Nack, and G. Chen*Pd-Catalyzed Monoselective ortho-C–H Alkylation of N-Quinolyl Benzamides: Evidence for Stereoretentive Coupling of Secondary Alkyl IodidesJ. Am. Chem. Soc. 2015, 137, 531. S.-Y. Zhang, Q. Li, G. He, W. A. Nack, and G. Chen*Stereoselective Synthesis ofβ-Alkylatedα-Amino Acids via Palladium-Catalyzed Alkylation of Unactivated Methylene C(sp3)-H Bonds with Primary Alkyl HalidesJ. Am. Chem. Soc. 2013, 135, 12135. S.-Y. Zhang,G. He, W. A. Nack, Y. Zhao, Q. Li, and G. Chen*Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)−H Bonds with Alkyl IodidesJ. Am. Chem. Soc. 2013,135, 2124. S.-Y. Zhang, G. He, Y. Zhao, K. Wright, W. A. Nack, and G. Chen*Efficient alkyl ether synthesis via palladium-catalyzed, picolinamide-directed alkoxylation of unactivated C(sp3)-H and C(sp2)-H bonds at remote positionsJ. Am. Chem. Soc. 2012, 134, 7313. S.-Y. Zhang, F.-M. Zhang and Y.-Q. Tu*Direct Sp3α-C-H activation and functionalization of alcohol and etherChem. Soc. Rev. 2011, 40, 1937. S.-Y. Zhang, Y.-Q. Tu,* C.-A. Fan, F.-M. Zhang, and L. ShiIron-Catalyzed C(sp3)-C(sp3) Bond Formationvia sp3C-H Functionalization: A Cross-Coupling Reaction of Alcohols with AlkenesAngew. Chem. Int. Ed. 2009, 48, 8761.