张川 - 上海交通大学 - 化学化工学院

个人简介

Dr. Chuan Zhang got his bachelor and master degree of Chemistry at Tsinghua University, Beijing. After that, he continued his PhD study at Purdue University and obtained the PhD degree in Chemistry in 2011 under supervision of Prof. Chengde Mao. Then he received the postdoctoral training in the group of Prof. Chad A. Mirkin at Northwestern University, USA. He joined the School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University as an Assistant Professor in 2014. His main research interests focus on DNA supramolecular chemistry, DNA-based nanomaterials for biomedical applications, cell-material interactions, and materials engineering for immunomodulation. He has previously received the M. G. Mellon Award in 2010 and “Qiu Shi” Outstanding Young Scholar Award in 2014.

研究领域

Our Researches focus on DNA nanotechnology, Supramolecular self-assembly, Exosome, and the Engineered Nanomaterials for biomedical applications, including: 1) Nucleoside analogue based nanomedicine 2) DNA nanostructure based biomacromolecule delivery system 3) Exosome-based biodiagnosis and therapy

近期论文

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Xihui Gao, Sha Li, Fei Ding, Xinlong Liu, Yijing Wu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Virus-Mimicking Nucleic Acid Nanogel Reprograms the Microglia and Macrophage for Glioblastoma Therapy”, Adv. Mater., 2020, in press. Xiangang Huang, Ru Zheng, Fei Ding, Jiapei Yang, Miao Xie, Xinlong Liu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Efficient Delivery of mRNA Using Crosslinked Nucleic Acid Nanogel as A Carrier”, ACS Mater. Lett., 2020, in press. Dongbo Guo, Yu Huang, Xin Jin*, Chuan Zhang, Xinyuan Zhu*, “A Redox-Responsive, In-Situ Polymerized Polyplatinum(IV)-Coated Gold Nanorod as An Amplifier of Tumor Accumulation for Enhanced Thermo-Chemotherapy”, Biomaterials, 2020, 266, 120400. Yan Liu, Jin Cheng, Sisi Fan, Huan Ge, Tao Luo, Linlin Tang, Bin Ji, Chuan Zhang, Daxiang Cui, Yonggang Ke, Jie Song*, “Modular Reconfigurable DNA Origami: from 2D to 3D”, Angew. Chem. Int. Ed., 2020, https://doi.org/10.1002/anie.202010433 Qiushuang Zhang, Fei Ding, Xinlong Liu, Jian Shen*, Yue Su, Jiwen Qian, Xinyuan Zhu*, Chuan Zhang*, “Nanobody-guided targeted delivery of microRNA via nucleic acid nanogel to inhibit the tumor growth”, Journal of Controlled Release, 2020, in press. Sisi Fan, Jin Cheng, Yan Liu, Dongfang Wang, Tao Luo, Bin Dai, Chuan Zhang, Daxiang Cui, Yonggang Ke, Jie Song*, “Proximity-Induced Pattern Operations in Reconfigurable DNA Origami Domino Array”, J. Am. Chem. Soc., 2020, https://doi.org/10.1021/jacs.0c06061. Lijuan Zhu, Yuanyuan Guo, Qiuhui Qian, Deyue Yan, Yuehua Li, Xinyuan Zhu, Chuan Zhang*, “Carrier-Free Delivery of Precise Drug-Chemogene Conjugates for Synergistic Treatment of Drug-Resistant Cancer”, Angew. Chem. Int. Ed., 2020, DOI: 10.1002/anie.202006895. Yushuang Ren, Yuanyuan Guo, Xueyi Liu, Jie Song, Chuan Zhang*, “Platinum(IV) prodrug-grafted phosphorothioate DNA and its self-assembled nanostructure for targeted drug delivery”, Chemical Research in Chinese Universities, 2020, in press. Yuanyuan Guo, Jiao Zhang, Gaifang Pan, Chung Hang Jonathan Choi, Ping Wang, Yuehua Li, Xinyuan Zhu, Chuan Zhang*, “Grafting Multi-Maleimides on Antisense Oligonucleotide to Enhance Its Cellular Uptake and Gene Silencing Capability”, Chemical Communications, 2020, 56, 7439-7442. Jiao Zhang, Yuanyuan Guo, Gaifang Pan, Ping Wang, Yuehua Li*, Xinyuan Zhu, Chuan Zhang*, “Injectable Drug-Conjugated DNA Hydrogel for Local Chemotherapy to Prevent Tumor Recurrence”, ACS Appl. Mater. Interfaces, 2020, 12, 21441-21449. Huan Ge, Dongya Wang, Yue Pan, Yuanyuan Guo, Hongyu Li, Fan Zhang, Xinyuan Zhu, Yuehua Li, Chuan Zhang*, Ling Huang*, “Sequence-Dependent DNA Functionalization of Upconversion Nanoparticles and Their Programmable Assemblies”, Angew. Chem. Int. Ed., 2020, 59, 8133-8137. Fei Ding, Xihui Gao, Xiangang Huang, Huan Ge, Miao Xie, Jiwen Qian, Jie Song, Yuehua Li*, Xinyuan Zhu, Chuan Zhang*, “Polydopamine-coated nucleic acid nanogel for siRNA-mediated low-temperature photothermal therapy”, Biomaterials, 2020, 245, 119976. Sha Li, Yijing Wu, Fei Ding, Jiapei Yang, Jing Li, Xihui Gao*, Chuan Zhang*, Jing Feng*, “Engineering macrophage-derived exosomes for targeted chemotherapy of triple-negative breast cancer”, Nanoscale, 2020, 12, 10854-10862. Travis A. Meyer, Chuan Zhang, Gang Bao, Yonggang Ke*, “Programmable Assembly of Iron Oxide Nanoparticles Using DNA Origami”, Nano Lett., 2020, 20, 2799-2805. Dongbo Guo, Shuting Xu, Wumaier Yasen, Chuan Zhang*, Jian Shen*, Yu Huang, Dong Chen, Xinyuan Zhu*, “Tirapazamine-embedded polyplatinum (IV) complex: a prodrug combo for hypoxia-activated synergistic chemotherapy”, Biomaterials Science, 2020, 8, 694-701. Gaifang Pan, Yuan Ma, Jiao Zhang, Yuanyuan Guo, Fei Ding, Huan Ge, Qifeng Li, Xinyuan Zhu, Chuan Zhang*, “Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery”, Chemical Research in Chinese Universities, 2019, 36, 274-280. Gaifang Pan, Quanbing Mou, Yuan Ma, Fei Ding, Jiao Zhang, Yuanyuan Guo, Xiangang Huang, Qifeng Li, Xinyuan Zhu, Chuan Zhang*, “pH-Responsive and Gemcitabine-Containing DNA Nanogel to Facilitate the Chemodrug Delivery”, ACS Appl. Mater. Interfaces, 2019, 11, 41082-41090. Fei Ding, Xiangang Huang, Xihui Gao, Miao Xie, Gaifang Pan, Qifeng Li, Jie Song, Xinyuan Zhu, Chuan Zhang*, “A Non-cationic Nucleic Acid Nanogel for the Delivery of CRISPR/Cas9 Gene Editing Tool”, Nanoscale, 2019, 11, 17211-17215 . Jiao Zhang, Yuanyuan Guo, Fei Ding, Gaifang Pan, Xinyuan Zhu, and Chuan Zhang*, “Camptothecin-Grafted DNA Tetrahedron as Precise Nanomedicine to Inhibit the Tumor Growth”, Angew. Chem. Int. Ed., 2019, 58, 13794-13798. Yuan Ma, Quanbing Mou, Lijuan Zhu, Yue Su, Xin Jin, Jing Feng, Deyue Yan, Xinyuan Zhu, and Chuan Zhang*, “Polygemcitabine nanogel with accelerated drug activation for cancer therapy”, Chemical Communications, 2019, 55, 6603-6606. Xihui Gao, Sha Li, Fei Ding, Hongjia Fan, Leilei Shi, Lijuan Zhu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Rapid Detection of Exosomal microRNAs Using Virus-Mimicking Fusogenic Vesicles”, Angew. Chem. Int. Ed., 2019, 58, 8719-8723.