Chamberlin, A. Richard - University of California, Irvine

个人简介

Fellow, American Association for the Advancement of Science Eli Lilly Grantee UCI Physical Sciences, Distinguished Teaching Award NIH Career Development Award in neuroscience

研究领域

Chemical Biology/Organic and Synthetic

近期论文

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Kaitocephalin Antagonism of Glutamate Receptors Expressed in Xenopus Oocytes Limon, A.; Reyes-Ruiz, J. M.; Vaswani, R. G.; Chamberlin, A. R.; Miledi, R. ACS Chem. Neurosci. 2010, 1, 175–181 Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (–)-kaitocephalin Vaswani, R. G.; Limon, A.; Reyes-Ruiz, J. M.; Miledi, R.; Chamberlin, A. R. Bioorg. Med. Chem. Lett. 2009, 19, 132–135 Methods for the Chemical Synthesis of Noncoded a-Amino Acids Found in Natural Product Peptides Habay, S. A.; Park, S. S.; Kennedy, S. M.; Chamberlin, A. R., Amino Acids, Peptides and Proteins in Organic Chemistry:Vol1-Origins and Synthesis of Amino Acids, Andrew B. Hughes (ed.), Wiley-VCH, 2009, pp. 163-244. Stereoselective Synthesis of Chiral IBR2 Analogues Qiu, X. L.; Zhu, J.; Wu, G.; Lee, W. H.; Chamberlin, A. R. J. Org. Chem. 2009, 74, 2018–2027 Synthesis and Biological Evaluation of a Series of Novel Inhibitor of Nek2/Hec1 Analogues Qiu, X. L.; Li, G.; Wu, G.; Zhu, J.; Zhou, L.; Chen, P. L.; Chamberlin, A. R.; Lee, W. H. J. Med Chem. 2009, 52, 1757–1767 Synthesis and pharmacological in vitro and in vivo profile of SHA 68 (3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide), a selective antagonist of the Neuropeptide S receptor Okamura, N.; Habay, S. A.; Zeng, J.; Chamberlin, A. R.; Reinscheid, R. K. Journal of Pharmacology and Experimental Therapeutics, 2008, 325(3), 893-901. Activation of Protein Phosphatase 1 by a Small Molecule Designed to Bind to the Enzyme's Regulatory Site Tappan, E.; Chamberlin, A.R. Chemistry and Biology, 2008, 15, 167-174. Stereocontrolled Total Synthesis of (-)-Kaitocephalin Vaswani, R.G.; Chamberlin, A.R. J. Org. Chem., 2008, 73(5), 1661-1681. Diastereoselective Synthesis of Glutamate-Appended Oxolane Rings: Synthesis of (S)-(+)-Lycoperdic Acid. Cohen, J.L.; Chamberlin, A.R. J. Org. Chem., 2007, 72(24), 9240-9247. Synthesis of the dysiherbaine tetrahydropyran core employing a tethered aminohydroxylation reaction. Cohen, J.L.; Chamberlin, A.R. Tet. Lett., 2007, 48, 2533-2536 Design, synthesis, and biological evaluation of chicoric acid analogs as inhibitors of HIV-1 integrase. Charvat, T. T.; Lee, D. J.; Robinson, W. E.; Chamberlin, A. R. Bioorg. Med. Chem., 2006, 14(13), 4552-4567 Pharmacophore Identification: The Case of the Ser/Thr Protein Phosphatase Inhibitors. Colby, D.A.; Chamberlin, A.R. Mini-Reviews in Medicinal Chemistry, 2006, 6(6), 657-665. A Central Strategy for Converting Natural Products into Fluorescent Probes. Alexander, M. D.; Burkart, M. D.; Leonard, M.l S.; Portonovo, P.; Liang, B.; Ding, X.; Joullie, M. M.; Gulledge, B.M.; Aggen, J. B.; Chamberlin, A. R.; Sandler, J.; Fenical, W.; Cui, J.; Gharpure, S. J.; Polosukhin, A.; Zhang, H.; Evans, P. A.; Richardson, A. D.; Harper, M. K.; Ireland, C.M.; Vong, B. G.; Brady, T. P.; Theodorakis, E. A.; La Clair, J. J. ChemBiochem., 2006, 7(3), 409-416. Design, Synthesis and Biological Evaluation of a Scaffold for iGluR Ligands Based on the Structure of (-)-Dysiherbaine. Cohen, J.L.; Limon, A.; Miledi, R.; Chamberlin, A.R. Bioorg. Med. Chem. Lett., 2006, 16(8), 2189-2194. The substituted aspartate analogue L-B-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3. Esslinger, C. S.; Agarwal, S.; Gerdes, J.; Wilson, P. A.; Davis, E. S.; Awes, A. N.; O'Brien, E.; Mavencamp, T.; Koch, H. P.; Poulsen, D.J.; Rhoderick, J. F.; Chamberlin, A. R.; Kavanaugh, M.P.; Bridges, R. J. Neuorpharmacology, 2005, 49(6), 850-861. Fluorescent Profiling of Natural Product Producers. Sandler, J.S., Fenical, W., Gulledge, B.M., Chamberlin, A.R., La Clair, J.J. J. Am. Chem. Soc. 2005, 127, 9320-9321. Indole- and indoline-based kainate analogues with antagonist activity at ionotropic glutamate receptors. Shou, X., Miledi, R., Chamberlin, A.R. Bioorg. Med. Chem. Lett. 2005, 15, 3942-3947. Modified norcantharidins synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity. Hart, M.E., Chamberlin, A.R., Walkom, C., Sakoff, J.A., McCluskey, A. Bioorg. Med. Chem. Lett. 2004, 14, 1969-1973. Ligands for kainate subtype glutamate receptors. Shou, X., Chamberlin, A.R. Expert Opinion on Therapeutic Patents 2004, 14, 471-486. Bridging the Synthetic and Biopolymer Worlds with Peptide-Drug Conjugates Weiss, G.A.; Chamberlin, R. Chem. Biol., 2003, 10(3), 201-202. 'Linearized' and Truncated Microcystin Analogues as Inhibitors of PP1 and PP2A. Gulledge B.M., Aggen J.B., Huang H.-B., Nairn A.C., Chamberlin A.R. Bioorg. Med. Chem. Lett. 2003, 13, 2903-2906.