涂永强 - 上海交通大学 - 化学化工学院

个人简介

涂永强1982年兰州大学化学系有机化学专业毕业，1985和1989年在兰州大学分别获得硕士(有机碘杂环化学)和博士(天然产物化学)学位，导师黄文魁教授和陈耀祖教授；1993年1月在澳大利亚昆士兰大学作博士后研究(天然产物化学)，合作导师William Kitching教授。1995年10月回国后在兰州大学任教授；1996-1998年任兰州大学化学系副主任；1999年获得国家自然科学基金委资助的杰出青年基金；2005年受聘教育部“长江学者特聘教授”；2001-2010年任功能有机分子化学国家重点实验室主任；2009年当选中国科学院院士；2014年作为双聘教授加盟上海交通大学，并于2018-2022年任上海交通大学化学化工学院院长。2012-2018年任英国皇家化学会杂志Chem. Commun.副主编。现任中国化学会常务理事，中国化学会会士，英国化学会会士。曾获中国化学会“青年化学奖”、“有机合成奖”和“手性化学奖”，国家教委科技进步二等奖，香港求是基金会“杰出青年学者奖”，三次省部级科技进步及自然科学一等奖，美国礼来公司“礼来科研成就奖”。2012年被授予“全国优秀科技工作者”称号。2016年获“国家自然科学二等奖”。2022年获何梁何利“科学与技术进步奖”。已在国际著名期刊发表研究论文260多篇。总引用25830次，H指数74(截至2022年12月)。

研究领域

主要从事有机合成方法、天然产物合成和金属有机化学领域的研究。

近期论文

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Total Synthesis of the Hexacyclic Sesterterpenoid Niduterpenoid B via Structural Reorganization Strategy Yuan Xue, Si-Hua Hou*, Xiang Zhang, Fu-Min Zhang, Xiao-Ming Zhang and Yong-Qiang Tu* J. Am. Chem. Soc. 2024, , 10.1021/jacs.4c09555. CCC Pincer Ru Complex-Catalyzed C-H Vinylation/6π-E-Cyclization of Aldimines for Constructing 4H-Pyrido[1,2-a]pyrimidines Heng Cai, Yong Qiang Tu,* Qiang Niu, Wen-Ping Xie, Bin Wang, Lu Ka, Zi-Hao Li, Fu-Min Zhang and Xiao-Ming Zhang Chem. Sci. 2024, , 10.1039/D4SC05067C. Organo-cation catalyzed enantioselective α-hydroxylation of pyridinone-fused lactones: asymmetric synthesis of SN-38 and irinotecan Jin-Rui Tian, Yu-Hao Qiao, Qing-Bo Zhuang, Rong Fan, Zhen Li, Xiao-Ming Zhang*, Fu-Min Zhang and Yong-Qiang Tu* Chem. Commun. 2024, , 10.1039/D4CC03580A. Expansion of Structure Property in Cascade Nazarov Cyclization and Cycloexpansion Reaction to Diverse Angular Tricycles and Total Synthesis of Nominal Madreporanone Kun Fang, Bao-Heng Dou, Fu-Min Zhang, Yun-Peng Wang, Zi-Rui Shan, Xiao-Yu Wang, Si-Hua Hou, Yongqiang Tu* and Tong-Mei Ding Angew. Chem. Int. Ed. 2024, , 10.1002/anie.202412337. Asymmetric Intramolecular Amination Catalyzed with Cp*Ir-SPDO via Nitrene Transfer for Synthesis of Spiro-Quaternary Indolinone Shi-Qiang Wei, Zi-Hao Li, Shuang-Hu Wang, Hua Chen, Xiao-Yu Wang, Yun-Zhou Gu, Ye Zhang, Hong Wang, Tong-Mei Ding, Shu-Yu Zhang* and Yong-Qiang Tu* J. Am. Chem. Soc. 2024, 146, 18841. Atroposelective synthesis of biaxial bridged eight-membered terphenyls via a Co/SPDO-catalyzed aerobic oxidative coupling/desymmetrization of phenols Shuang-Hu Wang, Shi-Qiang Wei, Ye Zhang, Xiao-Ming Zhang, Shu-Yu Zhang, Kun-Long Dai, Yong-Qiang Tu, Ka Lu and Tong-Mei Ding Nat. Commun. 2024, 15, 4591. Ni-Catalyzed Enantioselective Reductive Cross- and Homo-Coupling of Aryl Electrophiles: Synthesis of Axially Chiral Diaryl Dicarboxylates Ye Zhang, Yun-Zhou Gu, Ka Lu, Yun-Peng Wang, Ai-Fang Wang, Shuang-Hu Wang, Shi-Qiang Wei, Fu-Min Zhang, Xiao-Ming Zhang, Ai-Jun Ma, Jin-Bao Peng and Yong-Qiang Tu CCS Chem. 2024, , 10.31635/ccschem.024.202404027. Catalytic Asymmetric Synthesis of Vicinal Quaternary Stereocenters Enabled by Alkylation of α,α-Disubstituted Aldehydes with 3-Bromooxindoles Long-Jun Dong, Qi Wang, Jing-Feng Zhang, Zhen Li, Dao-Yong Zhu, Xiao-Ming Zhang*, Yong-Qiang Tu, and Shao-Hua Wang* Org. Lett. 2024, 26, 3086. Regioselective 1,n-Diborylation of Alkylidenecyclopropanes Enabled by Catalysis with a Spirocyclic NHC Ir(III) Pincer Complex Wei-Feng Wang, Ka Lu, Peng-Rui Liu, Hui-Hui Zeng, Li-Miao Yang, Ai-Jun Ma, Yong-Qiang Tu*, and Jin-Bao Peng* ACS Catal. 2024, 14, 5156. Catalytic Asymmetric Polycyclization of Tertiary Enamides with Silyl Enol Ethers: Total Synthesis of (−)-Cephalocyclidin A Zhuang, Q.-B.; Tian, J.-R.; Lu K.; Zhang, X.-M.*; Zhang, F.-M.; Tu, Y.-Q.*; Fan, R.; Li, Z.-H. and Zhang, Y.-D. J. Am. Chem. Soc. 2023, 145, 26550. Enantioselective synthesis of 2,3,3a,8a-tetrahydrofuro[2,3-b]benzofuran scaffolds enabled by Cu(II)/SPDO-catalyzed [3+2] cycloaddition of 2,3-dihydrofuran and quinone esters. Zhu, J.-X., Tian, J.-M., Chen, Y.-Y., Hu, X.-J., Han, X., Chen, W.-C., Yang, Z.-K., Bao, X.-Z., Ye, X.-Y., Chen, H., Zhang, F.-M., Wang, H.*, and Tu, Y.-Q.* J. Org. Chem. 2023, 88, 14670. Catalytic enantioselective alkylation of aldehydes with 3‑bromooxindoles. Li, Z., Zhang, X.-M.*, Zhang, F.-M., Tu, Y.-Q. Org. Lett. 2023, 25, 7252. NiH-Catalyzed Regio- and Enantioselective Hydroalkylation for the Synthesis of β- or γ-Branched Chiral Aromatic N-Heterocycles Yang, J.-S., Lu, K., Li, C.-X., Zhao, Z.-H., Zhang, F.-M.*, Zhang, X.-M., Tu, Y.-Q.* J. Am. Chem. Soc. 2023, 145, 22122. Total Syntheses of Polycyclic Diterpenes Phomopsene, Methyl Phomopsenonate, and iso-Phomopsene via Reorganization of C–C Single Bonds Yin, J.-J., Wang, Y.-P., Xue, J., Zhou, F.-F., Shan, X.-Q., Zhu, R., Fang, K., Shi, L.*, Zhang, S.-Y., Hou, S.-H.*, Xia, W.-J., Tu, Y.-Q.* J. Am. Chem. Soc. 2023, 145, 21170. Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems Wang, A.-F., Tian, J.-M., Zhao, X.-J., Li, Z.-H., Zhang, Y., Lu, K., Wang, H., Zhang, S.-Y.*, Tu, Y.-Q.*, Ding, T.-M., and Xie, Y.-Y. Angew. Chem. Int. Ed. 2023, 62, e202308858.. Catalytic Asymmetric Syntheses of 2,5-Diketopiperazine (DKP) Frameworks Yang, J.-S., Zhang, F.-M.*, Ma, A.-J., Peng, J.-B., Zhang, K., Zhang, X.-M.*, and Tu, Y.-Q.* Asian J. Org. Chem. 2023, 12, e202300177. Aromatic and olefinic C-H alkenylation by catalysis with spirocyclic NHC Ru(IV) pincer complex. Cai, H., Tu, Y.-Q.*, Lu, K., Chen, Q.-L., Zhang, F.-M., Zhang, X.-M., Pan, Y.-J., and Yan, Z.-B. Sci China Chem 2023, 66, 2791. Synthesis and characterization of Ir(III) complexes with highly nucleophilic spirocyclic 6-membered ring's NHC ligands. Yan, Z.-B.; Peng, M.; Xie, W.-P.; Wang, H.; Lu, K.; Peng, J.-Q.; Cai, H.; Dai, K.-L.; Zhang, F.-M.; Zhang, X.-M.; Tu, Y.-Q.* Sci Scn Chim 2023, 53, 516. Catalytic enantioselective Steglich-type rearrangement of enol lactones: Asymmetric synthesis of spirocyclic 1,3-diketones. Zhang, X.-Y., Lu, K., Guo, B.-K., Shao, Y.-P., Wang, H., Zhang, F.-M., Tu, Y.-Q., and Zhang, X.-M.* J. Org. Chem 2022, 87, 15031. 246. Cu(II)/SPDO complex catalyzed asymmetric Baeyer–Villiger oxidation of 2-arylcyclobutanones and its application for the total synthesis of eupomatilones 5 and 6. Zhang, C.-S., Shao, Y.-P., Zhang, F.-M.,* Han, X., Zhang, X.-M., Zhang, K., and Tu, Y.-Q.* Chem. Sci 2022, 13, 8429. An efficient approach to angular tricyclic molecular architecture via Nazarov-like cyclization and double ring-expansion cascade. Wang, Y.-P.#, Fang, K.#, Tu, Y.-Q.*, Yin, J.-J., Zhao, Q., and Ke, T. # = contributed equally. Nat. Commun. 2022, 13, 2335. Chiral 1,2,3-triazolium salt catalyzed asymmetric mono- and dialkylation of 2,5-diketopiperazines with the construction of tetrasubstituted carbon centers. Yang, J.-S.; Lu, K.; Li, C.-X.; Zhao, Z.-H.; Zhang, X.-M.; Zhang, F.-M.*; Tu, Y.-Q*. Angew. Chem. Int. Ed. 2022, 61, e202114129. . Facile benzylic alkylation of arenes with alcohols by catalysis with spirocyclic NHC Ir Dai, K.-L., Chen, Q.-L., Xie, W.-P., Lu, K., Yan, Z.-B., Peng, M., Li, C.-K., Tu, Y.-Q.*, and Ding, T.-M. Angew. Chem. Int. Ed. 2022, , e202206446.. Copper-Nitrene-Catalyzed Desymmetric Oxaziridination/1,2-Alkyl Rearrangement of 1,3-Diketones toward Bicyclic Lactams Han, X.; Shan, L.-X.; Zhu, J.-X.; Zhang, C.-S.; Zhang, X.-M.; Zhang, F.-M.*; Wang, H.; Tu, Y.-Q.*; Yang, M.; Zhang, W.-S. Angew. Chem.Int. Ed. 2021, 60, 22688. Enantioselective Synthesis of 3,3′-Disubstituted 2-Amino-2′-hydroxy-1,1′-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling Zhao, X.-J.; Li, Z.-H.; Ding, T.-M.; Tian, J.-M.*; Tu, Y.-Q.*; Wang, A.-F.; Xie, Y.-Y. Angew. Chem. Int. Ed. 2021, 60, 7061. An effective and versatile strategy for the synthesis of structurally diverse heteroarylsilanes via Ir(iii)-catalyzed C–H silylation Yan, Z.-B.; Peng, M.; Chen, Q.-L.; Lu, K.; Tu, Y.-Q.*; Dai, K.-L.; Zhang, F.-M.; Zhang, X.-M. Chem. Sci. 2021, 12, 9748. Recent development and applications of semipinacol rearrangement reactions Zhang, X.-M.; Li, B.-S.*; Wang, S.-H.*; Zhang, K.; Zhang, F.-M.; Tu, Y.-Q. Chem. Sci. 2021, 12, 9262. Catalytic enantioselective synthesis of chiral spirocyclic 1,3-diketones via organo-cation catalysis Zhang, X.-Y.; Shao, Y.-P.; Guo, B-K.; Zhang, K.; Zhang, F.-M.; Zhang, X.-M.*; Tu, Y.-Q.* Chem. Commun. 2021, 57, 11233. Oxyallyl cation promoted dearomative semipinacol rearrangement: a facile stereodivergent synthesis of spiro-indolines with contiguous quaternary centers Xie, Y.-Y.; Wang, Y.-P.; Zhao, X.-J.; Wang, A.-F.; Chen, Z.-M.*; Tu, Y.-Q.* Chem. Commun. 2021, 57, 6632. Remote asymmetric conjugate addition catalyzed by a bifunctional spiro-pyrrolidine-derived thiourea catalyst Xu, M.-H.; Yuan, Y.-H.; Liang, D.-D.; Zhang, X.-M.*; Zhang, F.-M.; Tu, Y.-Q.*; Ma, A.-J.; Zhang, K.; Peng, J.-B. Org. Chem. Front. 2021, 8, 3292. Construction of the tetracyclic core of the Lycopodium alkaloid annotinolide C Guo, X.; Li, Y.-Y.; Wang, S.-H.; Zhang, F.-M.*; Li, B.-S.*; Tu, Y.-Q.*; Zhang, X.-M. Org. Chem. Front. 2021, 8, 2510. Enantioselective construction of 2-aryl-2,3-dihydrobenzofuran scaffolds using Cu/SPDO-catalyzed [3+2] cycloaddition. Jing, Z.-R.; Liang, D.-D.; Tian, J.-M.*; Zhang, F.-M.*; Tu, Y.-Q.* Org. Lett. 2021, 23, 1258.