Ghosh, Arun K. - Purdue University - Department of Chemistry

个人简介

2009-Present Ian P. Rothwell Distinguished Professor, Purdue University 2005-2009 Professor, Dept. of Chemistry, Purdue University, West Lafayette, IN 1999-2005 Professor, Dept. of Chemistry, University of Illinois at Chicago, Chicago, IL 1997-1999 Associate Professor, Dept. of Chemistry, University of Illinois at Chicago, Chicago, IL 1994-1997 Assistant Professor, Dept. of Chemistry, University of Illinois at Chicago, Chicago, IL 1988-1994 Research Fellow, Merck Research Laboratories, West Point, PA. 1985-1988 Post-doctoral fellow (Professor E. J. Corey), Harvard University, Cambridge, MA 1981-1985 Ph.D. Organic Chemistry, Dept. of Chemistry, University of Pittsburgh. 1979-1981 M.Sc. Organic Chemistry, Indian Institute of Technology, Kanpur, India. 1979 B.Sc. (Hons), Calcutta University, India.

近期论文

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“Organic Carbamates in Drug Design and Medicinal Chemistry" A. K. Ghosh and M. Brindisi. J. Med. Chem. 2015, ASAP. “Enantioselective Synthesis of Dioxatriquinane Structural Motifs for HIV-1 Protease Inhibitors Using a Cascade Radical Cyclization” A. K. Ghosh; C-X. Xu; H. L. Osswald. Tetrahedron Lett. 2015, ASAP. “A Novel Tricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor, GRL-0739, Effectively Inhibits the Replication of Multi-Drug-Resistant HIV-1 Variants and Has a Desirable Central Nervous System (CNS) Penetration Property In Vitro.” M. Amano; Y. Tojo; P. M. Salcedo-Gómez: G. I. Parham; P. Nyalapatla;. D. Das; A. K. Ghosh; H. Mitsuya. Antimicrob Agents Chemother. 2015, ASAP. “Insights into the Mechanism of Inhibition of CXCR4: Identification of Piperidinylethanamine Analogs as Anti-HIV Inhibitors” Das, D., Maeda, K., Hayashi, Y., Gavande, N., Desai,D. V., Chang, S. B., Ghosh, A. K., and Mitsuya, H. Antimicrob. Agents Chemother. 2015, ASAP. “Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-?ACP reductase (FabI)" S. Mehboob, J. Songs, K. E. Hevner, P-C. Su, T. Boci, L. Brubaker, L. Truong, T. Mistry,J. Deng, J. L. Cook, B. D. Santarsiero, A. K. Ghosh, M. E. Johnson. Bioorg. Med. Chem. Lett. 2015, 25, 1292-1296. “Structure-based design, synthesis and biological evaluation of novel b-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand” A. K. Ghosh, M. Brindisi, Y-C, Yen, X. Xu, X. Huang, T. Devasamudram, G. Bilcer, H. Lei, G. Koelsch, A. D. Mesecar, J. Tang. Bioorg. Med. Chem. Lett. 2015, 25, 668-672. “Design of Gem-difluoro-bis-Tetrahydrofuran as P2-Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation” A. K. Ghosh, S. Yashchuk, A. Mizuno, N. Chakraborty, J. Agniswamy, Y.-F. Wang, M. Aoki, P. M. Salcedo Gomez, M. Amano, I. T. Weber, H. Mitsuya ChemMedChem 2015, 10, 107-115. "Characterization of a Drosophila Ortholog of the Cdc7 Kinase: A Role for Cdc7 in Endoreplication Independent of Chiffon" R. Stephenson; M. R. Hosler; N. S. Gavande; A. K. Ghosh; V. M. Weake. J. Biol. Chem. 2015, 290, 1332-1347 “Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.” H. Hayashi, N. Takamune, T. Nirasawa, M. Aoki, Y. Morishita, D. Das, Y. Koh, A. K. Ghosh, S. Misumi and H. Mitsuya, Proc. Natl. Acad. Sci. USA, 2014, 79, 5697-5709. Structure-based Design of Drugs and Other Bioactive Molecules- Tools and Strategies, A. K. Ghosh and S. Gemma, Wiley-VCH, 2014, 475 pp. "Enantioselective Synthesis of Spliceostatin E and Evaluation of Biological Activity" A. Ghosh, A. M. Veitschegger, V. R. Sheri, K. A. Effenberger, M. S. Jurrica. Organic Letters 2014, 16, 6200-6203. “An enantioselective synthesis of a MEM-protected aetheramide A derivative.” A. K. Ghosh, K. V. Rao, S. Akasapu, Tetrahedron Lett. 2014, 55, 5191-5194. “Coronaviruses Resistant to a 3C-like Protease Inhibitor Are Attenuated for Replication and Pathogenesis Revealing a Low Genetic Barrier but High Fitness Cost of Resistance” Xufang Deng, Sarah E. St. John, Heather L. Osswald, Amornrat O’Brien, Bridget S. Banach, Katrina Sleeman, Arun K. Ghosh, Andrew D. Mesecar, and Susan C. Baker J. Virol. 2014, 88, 11886-11898. “A convergent synthesis of carbocyclic sinefungin and its C5 epimer.” A. K. Ghosh, Kai Lv Eur. J. Org. Chem. 2014, 6761-6768. "Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands." A. K. Ghosh, G. E. Schiltz, L. N. Rusere, H. L. Osswald, D. E. Walters, M. Amano, H. Mitsuya Org. Biomol. Chem. 2014, 12, 6842–6854. "FeCl3-catalyzed tandem Prins and Friedel–Crafts cyclization: a highly diastereoselective route to polycyclic ring structures” A. K. Ghosh, C, Keyes, A. M. Veitschegger Tetrahedron Lett. 2014, 55, 4251–4254. “Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives”A. K. Ghosh, Z.-H, Chen, K. A. Effenberger, M. S. Jurica J. Org. Chem.2014, 79, 5697–5709. “Total Synthesis of GEX1Q1, Assignment of C5 Stereoconfiguration and Evaluation of Spliceosome Inhibitory Activity” A. K. Ghosh, N. Ma Effenberger, K. A.; Jurica, M. S. Org. Lett. 2014, 16, 3154-3157. “An intramolecular cascade cyclization of 2-aryl indoles: efficient methods for the construction of 2,3-functionalized indolines and 3-indolinones.” A. K. Ghosh; Z.-H, Chen Org. Biomol. Chem. 2014, 12, 357-3571. “BACE1 inhibitors (β-secretase) for the treatment of Alzheimer's Disease,” A. K. Ghosh and H. L. Osswald. Chem. Rev. 2014, 43, 6765-6813.