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个人简介

毛华伟,教授、博士生导师,重庆市中青年医学高端人才,中华儿科学会免疫学组青委副组长、亚太免疫缺陷学会临床委员会秘书、美国临床免疫学会员、广东省罕见病学会免疫学组副组长、中国研究型医院学会过敏医学专委会青委、香港过敏医学会委员、深圳市海外高层次人才“孔雀计划”人才,兼香港大学儿童与青少年医学系助理教授、深圳市原发性免疫缺陷病重点实验室副主任等。临床工作主要从事儿童风湿性疾病、原发性免疫缺陷病(PID)、造血干细胞移植、以及PID遗传咨询与产前基因诊断等。开展PID与自身炎症性疾病临床转化研究,是最先采用下一代高通量测序技术研究PID新致病基因与发病机制的研究人员之一,全球首次鉴定了一种全新的PID致病基因,实现了中国在该领域零的突破。主持国家自然科学基金面上项目、香港研究资助局RGC、香港食物卫生署、深圳市发改委以及科创委等研究课题,担任FrontiersinImmunology编委、JournalofImmunologyResearch、Genes&Diseases等期刊审稿人等。近五年在JAllergyClinImmunol,FrontImmunol,JVirol等专业领域权威期刊发表20多篇SCI论文,总影响因子100多,总引用率1000多次。申请国家发明专利两项。获中国原发性免疫缺陷病年度贡献奖、深圳市医管五四“杰出青年”、产业发展与创新人才奖等多项奖励。 成果奖励 1.中国原发性免疫缺陷病年度贡献奖,2019 2.重庆市中青年医学高端人才,2019 3.重庆市医学会风湿病学术年会优秀论文,2019 4.深圳市医管中心五四“杰出青年”,2017 5.深圳市产业发展与创新人才奖,2015、2016、2017 6.深圳市海外高层次人才“孔雀计划”B类人才,2014 7.FirstPrizeforBestPosterPresentation,5thAnnualScientificMeeting,HongKongSocietyforPIID.2012 8.BestPosterAward,17thAnnualScientificMeeting,HongKongSocietyofFlowCytometry.2012 9.BestOralPresentationAward,2010ScientificMeetingofHongKongSocietyforImmunology.2010 10.TravelAward.HongKongSocietyforImmunology.2010

研究领域

原发性免疫缺陷病与自身炎症性疾病的精准医学研究

科研项目 1.国家自然科学基金面上项目:重症联合免疫缺陷病新型致病基因鉴定.2020-2023,55万,主持 2.引进人才基金,2018-2023,100万,主持 3.国家自然科学基金面上项目:全外显子组测序鉴定自身免疫淋巴细胞增生综合征致病基因及其机制研究,2017-2020,58万,主持 4.深圳市发改委未来产业发展专项,2015-2017,500万,共同主持 5.深圳市科创委项目:外显子组测序鉴定多重感染免疫缺陷患儿基因突变,2014-2016,10万,主持 6.香港研究资助局RGC项目:TheeffectsofBTKmutationonTLR3-mediatedtypeIIFNresponseagainstpoliovirusinfectioninX-linkedagammaglobulinemia.2014-2016,68.4万,共同主持 7.香港食物卫生署RFCID项目:ImmuneevasionofNaturalKillerCellsbyInfluenzaVirusinVivo.2011-2013,98.9万,共同主持

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.LukADW,NiK,WuY,LamKT,ChanKW,LeePP,TuW,MaoH#,LauYL#.TypeIandIIIinterferonProductionsareimpairedinX-linkedagammaglobulinemiaPatientsTowardPoliovirusbutnotinfluenzaVirus.FrontiersinImmunology.2018.doi:10.3389/mmu.2018.01826 2.MaoH#,YangW,LatourS,YangJ,WinterS,ZhengJ,NiK,LvM,LiuC,HuangH,Chan,KW,LeePPW,TuW,FischerA,LauYL#.RASGRP1mutationinautoimmunelymphoproliferativesyndrome-likedisease.JAllergyClinImmunol.2018,142(2):595-604.e16 3.MaoH#,LiuY,SiaSF,PeirisJSM,LauYL,TuW#.Avianinfluenzavirusdirectlyinfectshumannaturalkillercellsandinhibitscellactivity.VirologicaSinica.2017;32(2):122-9 4.LeePPW*,MaoH*,YangW,Chan,KW,HoMHK,LeeTL,ChanJFW,WooPCY,TuW,LauYL.PenicilliummarneffeiinfectionandImpairedInterferon-gammaImmunityinhumanswithAutosomalDominantGain-of-phosphorylationSTAT1mutations.JAllergyClinImmunol.2014;133(3):894-896.e5. 5.MaoH,YenHL,LiuY,LauYL,PeirisJSM,TuW.ConservationofTcellepitopesbetweenseasonalinfluenzavirusesandthenovelinfluenzaAH7N9virus.VirologicaSinica.2014;29(3):170-5 6.LiJ*,LiH*,MaoH*,YuM,YangF,FengT,FanY,LuQ,ShenC,YinZ,MaoM,TuW.ImpairedNKcellantiviralcytokineresponseagainstinfluenzavirusinsmall-for-gestational-ageneonates.CellMolImmunol.2013;10(5):437-43. 7.LiJ*,LiH*,MaoH*,YuM,FengT,YangF,FanY,LuQ,ShenC,YinZ,TuW,MaoM.Vγ9Vδ2-Tlymphocyteshaveimpairedantiviralfunctioninsmall-for-gestational-ageandpretermneonates.CellMolImmunol.2013;10(3):253-60. 8.MaoH,YangW,LeePW,HoHK,YangJ,ZengS,ChongCY,LeeTL,TuW,LauYL.ExomesequencingidentifiesnovelcompoundheterozygousmutationsofIL-10receptor1inneonatal-onsetCrohn'sdisease.GenesImmun.2012;13(5):437-42. 9.MaoH,TuW,LiuY,QinG,ZhengJ,ChanPL,LamKT,PeirisM,LauYL.Inhibitionofprimaryhumannaturalkillercellactivitybyinfluenzavirionandhemagglutinin.JVirol.2010;84(9):4148-57. 10.MaoH,TuW,QinG,LawHK,SiaSF,ChanPL,LiuY,LamKT,ZhengJ,PeirisM,LauYL.Influenzavirusdirectlyinfectshumannaturalkillercellsandinducescellapoptosis.JVirol.2009;83(18):9215-22. 11.MaoHW,YangXQ,ZhaoXD.CharacterizationofhumanmetapneumovirusesisolatedinChongqing,China.ChinMedJ.2008;121(22):2254-7. 12.LeePP,Lao-arayaM,YangJ,ChanKW,MaH,PeiLC,KuiL,MaoH,YangW,ZhaoX,TrakultivakornMandLauYL.ApplicationofFlowCytometryintheDiagnosticsPipelineofPrimaryImmunodeficienciesUnderlyingDisseminatedTalaromycesmarneffeiInfectioninHIV-NegativeChildren.Front.Immunol.10:2189.doi:10.3389/fimmu.2019.02189 13.LukADW,LeePP,MaoH,ChanKW,ChenXY,ChenTX,HeJX,KechoutN,SuriD,TaoYB,XuYB,JiangLP,LiewWK,JirapongsananurukO,DaengsuwanT,GuptaA,SinghS,RawatA,AbdulLatiffAH,LeeACW,ShekLP,NguyenTVA,ChinTJ,ChienYH,LatiffZA,LeTMH,LeNNQ,LeeBW,LiQ,RajD,BarboucheMR,ThongMK,AngMCD,WangXC,XuCG,YuHG,YuHH,LeeTL,YauFYS,WongWH,TuW,YangW,ChongPCY,HoMHK,LauYL.Familyhistoryofearlyinfantdeathcorrelateswithearlierageatdiagnosisbutnotshortertimetodiagnosisforseverecombinedimmunodeficiency.FrontImmunol.2017;8:808.doi:10.3389/fimmu.2017.00808 14.LiuY,ZhengJ,LiuY,WenL,HuangL,XiangZ,LamKT,LvA,MaoH,LauYL,TuW.UncompromisedNKcellactivationisessentialforvirus-specificCTLactivityduringacuteinfluenzavirusinfection.CellMolImmunol.2018;15(9):827-37. 15.HanY,LingMT,MaoH,ZhengJ,LiuM,LamKT,LiuY,TuW,LauYL.Influenzavirus-inducedlunginflammationwasmodulatedbycigarettesmokeexposureinmice.PLoSOne.2014;21;9(1):e86166. 16.ChanPL,ZhengJ,LiuY,LamKT,XiangZ,MaoH,LiuY,QinG,LauYL,TuW.TLR5SignalingEnhancestheProliferationofHumanAllogeneicCD40-ActivatedBCellInducedCD4(hi)CD25(+)RegulatoryTCells.PLoSOne.2013;8(7):e67969. 17.DouY,ZhaoY,ZhangZY,MaoHW,TuWW,ZhaoXD.RespiratorysyncytialvirusinfectioninduceshigherToll-likereceptor-3expressionandTNF-αproductionthanhumanmetapneumovirusinfection.PLoSOne.2013;8(9):e73488. 18.LingMT,TuW,HanY,MaoH,ChongWP,GuanJ,LamKT,LawHKW,PeirisJSM,TakahashiK,LauYL.MannosebindinglectincontributestodeleteriousinflammatoryresponseinpandemicH1N1andavianH9N2infection.JInfectDis.2012;205(1):44-53 19.WuY,MaoH,LingMT,ChowKH,HoPL,TuW,LauYL.SuccessiveinfluenzavirusinfectionandStreptococcuspneumoniaestimulationalterhumandendriticcellfunction.BMCInfectDis.2011;11:201 20.HuiKP,LeeSM,CheungCY,MaoH,LaiAK,ChanRW,ChanMC,TuW,GuanY,LauYL,PeirisJS.H5N1influenzavirus-inducedmediatorsupregulateRIG-Iinuninfectedcellsbyparacrineeffectscontributingtoamplifiedcytokinecascades.JInfectDis.2011;204(12):1866-78. 21.QinG,LiuY,ZhengJ,NgIH,XiangZ,LamKT,MaoH,LiH,PeirisJS,LauYL,TuW.Type-1responsesofhumanVgamma9Vdelta2TcellstoinfluenzaAviruses.JVirol.2011;85(19):10109-16 22.TuW,MaoH,ZhengJ,LiuY,ChiuSS,QinG,ChanPL,LamKT,GuanJ,ZhangL,GuanY,YuenKY,PeirisJSM,LauYL.CytotoxicTlymphocytesestablishedbyseasonalhumaninfluenzacross-reactagainst2009pandemicH1N1influenzavirus.JVirol.2010;84(13):6527-35. 23.QinG,MaoH,ZhengJ,SiaSF,LiuY,ChanPL,LamKT,PeirisJS,LauYL,TuW.Phosphoantigen-expandedhumangammadeltaTcellsdisplaypotentcytotoxicityagainstmonocyte-derivedmacrophagesinfectedwithhumanandavianinfluenzaviruses.JInfectDis.2009;200(6):858-65. 24.ZhengJ,LiuY,QinG,ChanPL,MaoH,LamKT,LewisDB,LauYL,TuW.Efficientinductionandexpansionofhumanalloantigen-specificCD8regulatoryTcellsfromnaiveprecursorsbyCD40-activatedBcells.JImmunol.2009;183(6):3742-50. 25.TuW,LauYL,ZhengJ,LiuY,ChanPL,MaoH,DionisK,SchneiderP,LewisDB.Efficientgenerationofhumanalloantigen-specificCD4+regulatoryTcellsfromnaiveprecursorsbyCD40-activatedBcells.Blood.2008;112(6):2554-62. 26.毛华伟.原发性免疫缺陷病分子诊断及新发原发性免疫缺陷病.中国实用儿科杂志,2017,32(7):491-6. 27.毛华伟,赵晓东.进一步加强免疫球蛋白G替代治疗原发性免疫缺陷病.中华儿儿科杂志.2017,55(1):1-3

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