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研究领域

(1)高分子生物材料(生物降解高分子、聚乳酸、聚己内酯、脂肪族聚酯) (2)生物高分子(聚氨基酸或聚肽、糖聚合物、糖蛋白缀合物) (3)纳米生物材料与纳米医学(自组装纳米结构、响应性纳米医学、诊断治疗剂) (4)药物控释体系与组织工程(靶向药物释放、多重响应性药物释放、可注射水凝胶)

近期论文

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Gang Liu, Linzhu Zhou, Yue Su and Chang-Ming Dong*,An NIR-responsive and sugar-targeted polypeptide composite nanomedicine for intracellular cancer therapy, Chem Comm 2014,50,12538-12541. Gang Liu , Linzhu Zhou , Yanfei Guan , Yue Su , Chang-Ming Dong *, Multi-Responsive Polypeptidosome: Characterization, Morphology Transformation,and Triggered Drug Delivery, Macromol. Rapid Commun. 2014, 35,1673-1678. Xiao Chang, Lisha Liu, Yanfei Guan, Chang-Ming Dong*, Disulfide-Centered Star-Shaped Polypeptide-PEO Block Copolymers for Reduction-Triggered Drug Release, J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 2000-2010. Lin Sun, Bangshang Zhu, Yue Su and Chang-Ming Dong*,Light-responsive linear-dendritic amphiphiles and their nanomedicines for NIR-triggered drug release, Polym. Chem., 2014, 5, 1605-1613. Xiao Chang, Chang-Ming Dong*,"Synthesis of Hyperbranched Polypeptide and PEO Block Copolymer by Consecutive Thiol-Yne Chemistry", Biomacromolecules 2013, 14, 3329−3337. Gang Liu, Wei Liu, Chang-Ming Dong*, “UV- and NIR-Responsive Polymeric Nanomedicines for On-Demand Drug Delivery”, Polym. Chem., 2013, 4,3431-3443(Invited review). Dong-Lin Liu, Xiao Chang, Chang-Ming Dong*, “Reduction- and thermo-sensitive star polypeptide micelles and hydrogels for on-demand drug delivery”, Chem Comm 2013, 49, 1229-1231. Chang-Ming Dong*, Gang Liu, “Linear-Dendritic Biodegradable Block Copolymers: From Synthesis To Application In Bionanotechnology”, Polym. Chem., 2013, 4, 46-52 (Invited Minireview, 6# of Top 10 Most Read article in Septemper, 2012). Lin Sun,Xiaofei Ma, Chang-Ming Dong*, Bangshang Zhu*, Xinyuan Zhu, 'NIR-Responsive and Lectin-Binding Doxorubicin-Loaded Nanomedicine from Janus-Type Dendritic PAMAM Amphiphiles', Biomacromolecules, 2012, 13, 3581-3591. (Most Read Articles: 6# of Top 20 in October 2012) Gang Liu, Chang-Ming Dong*, "Photoresponsive Poly(S-(o-nitrobenzyl)-L-cysteine)-b-PEO from a LCysteine N-Carboxyanhydride Monomer: Synthesis, Self-Assembly, and Phototriggered Drug Release", Biomacromolecules, 2012, 13, 1573-1583. (Most Read Articles: Top 20 in April-May 2012) Ye Liao, Chang-Ming Dong*, "Synthesis, Conformation Transition, Liquid Crystal Phase, and Self-Assembled Morphology of Thermosensitive Homopolypeptide",J Polym Sci Part A: Polym Chem 2012,50,1834–1843. Yu-Jing Wang, Chang-Ming Dong*, "Bioreducible and Core-Crosslinked Hybrid Micelles from Trimethoxysilyl-Ended Poly(e-caprolactone)-S-S-Poly(ethylene oxide) Block Copolymers: Thiol-Ene Click Synthesis and Properties", J Polym Sci Part A: Polym Chem 2012,50,1645–1656. You-Cui Xu, Chang-Ming Dong*, "Dendron-Like Poly(e-benzyloxycarbonyl-L-lysine)/Linear PEO Block Copolymers: Synthesis, Physical Characterization, Self-Assembly, and Drug-Release Behavior", J Polym Sci Part A: Polym Chem 2012, 50,1216–1225. Lin Sun, Wei Liu, Chang-Ming Dong*, "Bioreducible Micelles and Hydrogels with Tunable Properties from Multi-Armed Biodegradable Copolymer", Chem Comm 2011, 47,11282-11284. Lin Sun, Yang Yang, Chang-Ming Dong*, Yen Wei, "Two-Photon-Sensitive and Sugar-Targeted Nanocarriers from Degradable and Dendritic Amphiphiles", Small 2011, 7, 401-406. Wei Liu, Chang-Ming Dong*, "Versatile Synthesis of Asymmetrical Dendron-Like/Dendron-Like Poly(Caprolactone)-b-Poly(Benzyl-L-Glutamate) Block Copolymers", J. Polym. Sci. Polym. Chem. 2011, 49, 3491-3498. Wei Liu, Chang-Ming Dong*, “Versatile Strategy for the Synthesis of Hyperbranched Poly(e-caprolactone)s and Polypseudorotaxanes Thereof", Macromolecules 2010, 43, 8447-8455. Lin Sun, Lin-Jing Shen, Ming-Qiang Zhu, Chang-Ming Dong*, Yen Wei, “Synthesis, Self-Assembly, Drug-Release Behavior, and Cytotoxicity of Triblock and Pentablock Copolymers Composed of Poly(e-caprolactone),Poly(L-lactide), and Poly(ethylene glycol)”, J Polym Sci Polym Chem 2010, 48, 4583-4593. Yi Chen, Xiao-Hui Pang, Chang-Ming Dong*, “Dual Stimuli-Responsive Supramolecular Polypeptide-Based Hydrogel and Reverse Micellar Hydrogel Mediated by Host-Guest Chemistry”, Adv Funct Mater 2010, 20, 579-586. Yi Chen, Chang-Ming Dong*, "pH-Sensitive Supramolecular Polypeptide-Based Micelles and Reverse Micelles Mediated by Hydrogen-Bonding Interactions or Host-Guest Chemistry: Characterization and In Vitro Controlled Drug Release", J. Phys. Chem. B 2010, 114, 7461–7468.

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