Rychnovsky, Scott - University of California, Irvine

个人简介

Academic Distinctions Arthur C. Cope Scholar Award Fresenius Award Zeneca Chemistry Award Searle Scholar Fellow Camille and Henry Dreyfus Foundation Teacher-Scholar Eli Lilly Fellow Pfizer Research Award in Synthetic Organic Chemistry Alfred P. Sloan Fellow National Science Foundation Presidential Young Investigator Award S. T. Li Prize for Achievements in Science and Technology Associate Editor for The Journal of Organic Chemistry Fellow of the American Association for the Advancement of Science Fellow of the American Chemical Society Royal Society of Chemistry Pedler Award Appointments NIH Postdoctoral Fellow, Harvard University Faculty member at the University of Minnesota from 1988-1995 Joined UCI faculty in 1995

研究领域

Organic Chemistry, Synthesis and Structure Determination, Chemical Biology

近期论文

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“Total Synthesis and Structure Revision of (–)-Illisimonin A, a Neuroprotective Sesquiterpenoid from the Fruits of Illicium simonsii”Burns, A. S.; Rychnovsky, S. D. J. Am. Chem. Soc., 2019, Article ASAP. “Biosynthesis-Inspired Approach to Kujounin A2 Using A Stereoselective Tsuji-Trost Alkylation”Burtea, A.; Rychnovsky, S. D.; Org. Lett., 2018, 20, 5849–5852. “Second-Generation Synthesis of (+)-Fastigiatine Inspired by Conformational Studies”DeForest, J. C.; Samame, R. A.; Suryn, G.; Burtea, A.; Rychnovsky, S. D.; J. Org. Chem., 2018, 83 (16), 8914-8925. “Catalytic Enantioselective Allylations of Acetylenic Aldehydes via 2-Propanol-Mediated Reductive Coupling”Brito, G. A.; Della-Felice, F.; Luo, G.; Burns, A. S.; Pilli, R. A.; Rychnovsky, S. D.; Krische, M. J.; Org. Lett., 2018, 20 (13), 4144-4147. “Development of a Novel Sulfoxide-Containing MS-Cleavable Homobifunctional Cysteine-Reactive Cross-Linker for Studying Protein–Protein Interactions”Gutierrez, C. B.; Block, S. A.; Yu, C.; Soohoo, S. M.; Huszagh, A. S.; Rychnovsky, S. D.; Huang, L.; Anal. Chem., 2018, 90 (12), 7600-7607. DOI: 10.1021/acs.analchem.8b01287 “Heteroatom-Directed Acylation of Secondary Alcohols To Assign Absolute Configuration”Burns, A.; Ross, C.; Rychnovsky, S.; J. Org. Chem., 2018, 83, 2504-2515. “The Proteasome-Interacting Ecm29 Protein Disassembles the 26S Proteasome in Response to Oxidative Stress”Xiaorong Wang, Ilan E. Chemmama, Clinton Yu, Alexander Huszagh, Yue Xu, Rosa Viner, Sarah Ashley Block, Peter Cimermančič, Scott D. Rychnovsky, YiHong Ye, Andrej Sali and Lan Huang, J. Biol. Chem. 2017, ASAP. DOI: 10.1074/jbc.M117.803619 “Determination of the Absolute Configuration of Cyclic Amines with Bode’s Chiral Hydroxamic Esters Using the Competing Enantioselective Conversion Method”Burtea, A.; Rychnovsky, S. D. Org. Lett. 2017, 19 (16), 4195–4198. “Determination of the Absolute Configuration of β-Chiral Primary Alcohols Using the Competing Enantioselective Conversion Method”Burns, A. S.; Wagner, A. J.; Fulton, J. L.; Young, K.; Zakarian, A.; Rychnovsky, S. D. Org. Lett. 2017, 19 (11), 2953-2956. “Developing a Multiplexed Quantitative Cross-linking Mass Spectrometry Platform for Comparative Structural Analysis of Protein Complexes”Clinton Yu, Alexander Huszagh, Rosa Viner, Eric J. Novitsky, Scott Rychnovsky, Lan Huang, Anal. Chem. 2016, 88, 10301–10308. “Generation, Stability, and Utility of Lithium 4,4′-Di-tert-butylbiphenylide (LiDBB)”Hill, R. R.; Rychnovsky, S. D. J. Org. Chem. 2016, 81 (22), 10707–10714. “Distinct mechanisms underlying cholesterol protection against alcohol-induced BK channel inhibition and resulting vasoconstriction”Shivantika Bisen, Olga Seleverstov, Jitendra Belani, Scott Rychnovsky, Alex M. Dopico, Anna N. Bukiya, Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids 2016, 1861, 1756–1766. “Developing a Novel Acidic Residue Reactive and Sulfoxide-containing MS-cleavable Homobifunctional Cross-linker for Probing Protein-Protein Interactions”Craig B. Gutierrez, Clinton Yu, Eric J. Novitsky, Alex S. Huszagh, Scott Rychnovsky, Lan Huang, Anal. Chem. 2016, 88, 8315–8322. “Route to Highly Substituted Pyridines”Hilf, J. A.; Holzwarth, M. S.; Rychnovsky, S. D. J. Org. Chem. J. Org. Chem. 2016, 81, 10376–10382. “Nanomole-Scale Assignment and One-Use Kits for Determining the Absolute Configuration of Secondary Alcohols”Wagner, A. J.; Miller, S. M.; King, R. P.; Rychnovsky, S. D. J. Org. Chem., 2016, 81, 6253–6265. “Stereoselection in Intramolecular Diels–Alder Reactions of 2-Cyano-1-azadienes: Indolizidine and Quinolizidine Synthesis”Tay, G. C.; Sizemore, N.; Rychnovsky, S. D. Org. Lett. 2016, 18, 3050. “Concise Synthesis of (+)-Fastigiatine”Renzo A. Samame, Christina M. Owens and Scott D. Rychnovsky, Chem. Sci. 2016, 7, 188-190. “Gln40 Deamidation Blocks Structural Reconfiguration and Activation of SCF Ubiquitin Ligase Complex by Nedd8”Yu, C.; Mao, H.; Novitsky, E. J.; Tang, X.; Rychnovsky, S. D.; Zheng, N.; Huang, L. Nat. Commun. 2015, 6, 10053. “Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis”Jinqiang Liu, Clinton Yu, Xichan Hu, Jin-Kwang Kim, Jan C. Bierma, Hyun-Ik Jun, Scott D. Rychnovsky, Lan Huang, Feng Qiao, Cell Reports 2015, 12, 2169–2180. “Design of CID-cleavable protein cross-linkers: identical mass modifications for simpler sequence analysis”Kandur, W. V.; Kao, A.; Vellucci, D.; Huang, L.; Rychnovsky, S. D. Org. Biomol. Chem. 2015, 13, 9793–9807. “Generation, structure and reactivity of tertiary organolithium reagents”Perry, M. A.; Rychnovsky, S. D. Nat. Prod. Rep. 2015, 32, 517–533.