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有机污染物毒性的分子机理的研究

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Zhang, X.-Y.; Bishop, A. C. Engineered Inhibitor Sensitivity in the Activation Loop of a Protein Tyrosine Phosphatase. Biochemistry 2008, 47, 4491. Zhang, X.-Y.; Bishop, A. C. Site-Specific Incorporation of Allosteric-Inhibition Sites in a Protein Tyrosine Phosphatase. J. Am. Chem. Soc. 2007, 129, 3812-3813. Bishop, A. C.; Zhang, X.-Y.; Lone, A. M. Generation of Inhibitor-Sensitive Protein Tyrosine Phosphatases via Active-Site Mutations. Methods 2007, 42, 278-288. Zhang, X.-Y.; Elfarra, A. A. Characterization of 1,2,3,4-Diepoxybutane–2¢-Deoxyguanosine Cross-Linking Products Formed at Physiological and Non-Physiological Conditions. Chem. Res. Toxicol. 2006, 19, 547-555. Zhang, X.-Y.; Elfarra, A. A. Reaction of 1,2,3,4-Diepoxybutane with 2¢-Deoxyguanosine: Initial Products and Their Stabilities and Decomposition Patterns under Physiological Conditions. Chem. Res. Toxicol. 2005, 18, 1316-1323. Zhang, X.-Y.; Elfarra, A. A. Characterization of the Reaction Products of 2¢-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts. Chem. Res. Toxicol. 2004, 17, 521-528. Zhang, X.-Y.; Elfarra, A. A. Identification and Characterization of a Series of Nucleoside Adducts Formed by the Reaction of 2¢-Deoxyguanosine and 1,2,3,4-Diepoxybutane under Physiological Conditions. Chem. Res. Toxicol. 2003, 16, 1606-1615.

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