个人简介

Susan G. Komen Postdoctoral Fellow, 2008-2010 Stanford Molecular Imaging Scholar, 2007-2010 Howard Hughes Medical Institute Predoctoral Fellow, 2001-2006 UC Berkeley Outstanding Graduate Instructor, 2002 American Chemical Society Outstanding Graduate, 2001 Appointments Susan G. Komen postdoctoral fellow, Stanford University, 2008-2010

研究领域

Chemical Biology/Organic and Synthetic

The Prescher lab focuses on the development of chemical tools and noninvasive imaging strategies to probe immune function. The immune system comprises a vast network of disease-fighting cells that defend the body against multiple threats, but how these cells communicate over space and time to eliminate pathogens, cancer cells, and other hazards is not completely understood. The Prescher group aims to understand the complex interactions that underlie immune function by visualizing immune cells “in action”. In the lab, researchers utilize a combination of chemical and biological techniques to equip cells with various imaging probes. These probes are then used to track the movements, interactions, and functions of immune cells in whole organisms. Collectively, these studies are bringing chemistry from the test tube into living subjects, and illuminating the mechanisms employed by the immune system to combat disease.

近期论文

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Patterson, D. M.; Nazarova, L. A.; Xie, B. J.; Kamber, D. N.; Prescher, J. A. Functionalized cyclopropenes as bioorthogonal chemical reporters. J. Am. Chem. Soc. 2012, ASAP. McCutcheon, D. C.; Paley, M. A.; Steinhardt, R. C.; Prescher, J. A. Expedient synthesis of electronically modified luciferins for bioluminescence imaging. J. Am. Chem. Soc. 2012, 134, 7604-7607. Prescher, J. A.; Contag, C. H. Imaging mouse models of human cancer. In “Mouse Models for Cancer Research: Generation and Applications for Research and Pre-clinical Testing,” 2011, Eds (Springer): Green, J. and Ried, T. Liu, H.*; Patel, M. R.*; Prescher, J. A.*; Qian, D.; Chang, Y.; Lin, J.; Wen, S.; Shimono, Y.; Dalerba, P. D.; Adorno, M.; Lobo, N.; Dirbas, F. M.; Bueno, J.; Gambhir, S. S.; Contag, C. H.; Clarke, M. F.; Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 18115-18120. .Helms, M. W.; Prescher, J. A.; Thorne, S. H.; Contag, C. H. Educating cytokine-induced killer cells with IL-12 in vivo for breast cancer treatment. Cancer Immunol. Immunother. 2010, 9, 1325-1334. Prescher, J. A.; Contag C. H. Guided by the light: visualizing biomolecular processes in living animals. Curr. Opin. Chem. Biol. 2010, 14, 80-89 Muia, R. P.; Yu, H.; Prescher, J. A.; Hellman, U.; Chen, X.; Bertozzi, C. R.; Campetella, O. Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology 2010, <,i>20, 833-842. Chang, P. V.*; Prescher, J. A.*; Sletten, E. M.; Baskin, J. M.; Miller, I. A.; Agard, N. J.; Lo, A.; Berotzzi, C. R. Copper-free click chemistry in living animals. Proc. Natl. Acad. Sci. U.S.A. 2010, in press. [*these authors contributed equally to this work] Yap, M.; Kostiuk, M. A.; Hak, P.; Anjaiah, S.; Majjigapum, J. R.; Keller, B. O.; Prescher, J. A.; Wu, P.; Bertozzi, C. R.; Falck, J. R.; Berthiaume, L. G. Detection of palmitoylated proteins with an alkynyl-palmitate analogue in vitro, in cultured cells, and in vivo using click chemistry. J. Lipid Res. 2010, in press. Schultz, D. M.; Prescher, J. A.; Kidd, S.; Marona-Lewicka, D.; Nichols, D. E.; Monte, A. ‘Hybrid’ benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines. Bioorg. Med. Chem. 2008, 16, 6242-6251. Martin, D. D. O.; Vila, G. L.; Prescher, J. A.; Rajaiah, G.; Falck, J. R.; Bertozzi, C. R.; Berthiaume, L. G. Rapid detection and identification of new post-translationally myristoylated proteins during apoptosis using a bioorthogonal azido-myristate analogue. FASEB J. 2008, 22, 797-806. Kostiuk, M. A.; Corvi, M. M.; Keller, B. O.; Plummer, G.; Prescher, J. A.; Hangauer, M. J.; Bertozzi, C. R.; Rajaiah, G.; Falck, J. R.; Berthiaume, L. G. Identification of palmitoylated mitochondrial proteins using a bioorthogonal azido-palmitate analogue. FASEB J. 2008, 22, 721-732.