Overman, Larry E. - University of California, Irvine

个人简介

2011 UCI Medal, University of California, Irvine, American Chemical Society, Herbert C. Brown Award for Creative Research in Synthetic Methods, 2010, Tetrahedron Prize for Creativity in Organic Chemistry, 2008, The Nagoya Medal of Organic Chemistry, 2007, International Society of Heterocyclic Chemistry Senior Award, 2005, Ta-shue Chou Lectureship Award, 2004, American Chemical Society Arthur C. Cope Award, 2003, U.C. Irvine Distinguished Faculty Lectureship Award for Research, 2002-2003, Yamada Prize, 2002, 2000 Japan Society for the Promotion of Science Fellowship, 1999 S. T. Li Prize for Achievements in Science and Technology, Earlham College Distinguished Faculty Award 1999, Centenary Medal, Chemical Society, U.K., 1997, American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 1995, Guggenheim Fellowship, 1993-1994, C.S. Hamilton Award, University of Nebraska, 1993, Javits Neuroscience Investigator Award, 1985-1992; 1992-1999, American Chemical Society Arthur C. Cope Scholar Award, 1989, Visiting Miller Research Fellow, U.C. Berkeley, 1989, Alexander von Humboldt U.S. Senior Scientist Award, 1985-1987, Camille and Henry Dreyfus Teacher-Scholar Award, 1976-1981, U.C. Irvine School of Physical Sciences Distinguished Teaching Award, 1981, U.C. Irvine Alumni Association Distinguished Research Award, 1979, Alfred P. Sloan Foundation Fellow, 1975-1977

研究领域

Chemical Biology/Inorganic and Organometallic/Organic and Synthetic

近期论文

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"Constructing Quaternary Stereogenic Centers Using Tertiary Organocuprates and Tertiary Radicals. Total Synthesis of trans-Clerodane Natural Products" Müller, D. S.; Untiedt, N. L.; Dieskau, A. P.; Lackner, G. L.; Overman, L. E. J. Am. Chem. Soc. 2015, 137, 660—663. "Catalytic enantioselective synthesis of quaternary carbon stereocentres" Quasdorf, K. W.; Overman, L. E. Nature, 2014, 516, 181—191. "The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure–activity relationships" Shaghafi, M. B.; Barrett, D. G.; Willard, F. S.; Overman, L. E. Bioorganic & Medicinal Chemistry Letters 2014, 24, 1031—1036. "Direct Construction of Quaternary Carbons from Tertiary Alcohols via Photoredox-Catalyzed Fragmentation of tert-Alkyl N-Phthalimidoyl Oxalates" Gregory L. Lackner, Kyle W. Quasdorf, Larry E. Overman. Journal of the American Chemical Society 2013, 135, 15342—15345. "Enantioselective Synthesis of Angularly Substituted 1-Azabicyclic Rings: Coupled Dynamic Kinetic Epimerization and Chirality Transfer" Zachary D. Aron, Tatsuya Ito, Tricia L. May, Larry E. Overman, and Jocelyn Wang. Journal of Organic Chemistry 2013, 78, 9929—9948. "Enantioselective Total Synthesis of Plectosphaeroic Acids B and C" Salman Y. Jabri and Larry E. Overman. Journal of Organic Chemistry 2013, 78, 8766—8788. "Enantioselective Total Synthesis of Plectosphaeroic Acid B" Salman Y. Jabri and Larry E. Overman. Journal of the American Chemical Society 2013, 135, 4231—4234. "General Approach for Preparing Epidithiodioxopiperazines from Trioxopiperazine Precursors: Enantioselective Total Syntheses of (+)-and (−)-Gliocladine C, (+)-Leptosin D, (+)-T988C, (+)-Bionectin A, and (+)-Gliocladin A" John E. DeLorbe, David Horne, Richard Jove, Steven M. Mennen, Sangkil Nam, Fang-Li Zhang, and Larry E. Overman. Journal of the American Chemical Society 2013, 135, 4117—4128. "Origins of Stereoselectivities of Dihydroxylations of cis-Bicyclo[3.3.0]octenes" Hao Wang, Philipp Kohler, Larry. E. Overman, and K. N. Houk. Journal of the Americal Chemical Society 2012, 134, 16054—16058. "A Concise Synthesis of (—)-Aplyviolene Facilitated by a Strategic Tertiary Radical Conjugate Addition" Martin J. Schnermann, Larry E. Overman. Angewandte Chemie International Edition 2012, 51, 9576—9580. "Forming Tertiary Organolithium and Organocuprates from Nitrile Precursors and their Bimolecular Reactions with Carbon Electrophiles to Form Quaternary Carbon Stereocenters" Martin J. Schnermann, Nicholas L. Untiedt, Gonzalo Jimenez-Oses, Kendall N. Houk, Larry E. Overman. Angewandte Chemie International Edition 2012, 57, 9581—9586. "Total Synthesis of (+)-Sieboldine A: Evolution of A Pinacol-Terminated Cyclization" Stephen M. Canham, David J. France, Larry E. Overman. Journal of Organic Chemistry 2012, 78, 9—34. "Palladium(II)-Catalyzed Enantioselective Synthesis of 2-Vinyl Oxygen Heterocycles" Jeffrey S. Cannon, Angela C. Olson, Larry E. Overman, Nicole S. Solomon Journal of Organic Chemistry, 2012, 1961–1973. "Palladacyclic Imidazoline-Naphthalene Complexes: Synthesis and Catalytic Performance in Pd(II)-Catalyzed Enantioselective Reactions of Allylic Trichloroacetimidates" Jeffrey S. Cannon, James H. Frederich, and Larry E. Overman Journal of Organic Chemistry 2012, 1939–1951. "Is There No End to the Total Syntheses of Strychnine? Lessons to be Learned for Strategy and Tactics in Total Synthesis" Jeffrey S. Cannon and Larry E. Overman Angewandte Chemie, International Edition 2012, 51, Early View. "Enantioselective Total Synthesis of Aplyviolene" Larry E. Overman and Martin J. Schnermann Journal of the American Chemical Society 2011, 133, 16425–16427 "Divergent Synthesis and Chemical Reactivity of Bicyclic Lactone Fragments of Complex Rearranged Spongian Diterpenes" Martin J. Schnermann, Christopher M. Beaudry, Nathan E. Genung, Stephen M. Canham, Nicholas L. Untiedt, Breanne D. W. Karanikolas, Christine Sütterlin and Larry E. Overman Journal of the American Chemical Society 2011, 133, 17494–17503 "Identification of an Unexpected 2-Oxonia[3,3]sigmatropic Rearrangement/Aldol Pathway in the Formation of Oxacyclic Rings. Total Synthesis of (+)-Aspergillin PZ" Stephen M. Canham, Larry E. Overman and Paul S. Tanis Tetrahedron 2011, 67, 9837–9843 "Enantioselective Total Synthesis of (+)-Gliocladin C and (+)-Gliocladine C. A Convergent Construction of Cyclotryptamine-Fused Polyoxopiperazines and a General Approach for Preparing Epidithiodioxopiperazines from Trioxopiperazine Precursors" J. E. DeLorbe, S. Y. Jabri, S. M. Mennen, L. E. Overman and F-L Zhang Journal of the American Chemical Society 2011, 133, 6549–6552 "Total Synthesis of (+)-Condylocarpine (+)-Isocondylocarpine, and (+)-Tubotaiwine" C. L. Martin, S. Nakamura, R. Otte and L. E. Overman Organic Letters 2011, 13, 138–141: PMCID: PMC3014433 "Total Synthesis of (+)-Nankakurines A and B and (±)-5-epi-Nankakurine A" R. A. Altman, B. L. Nilsson, L. E. Overman, J. Read de Alaniz, J. M. Rohde and V. Taupin Journal of Organic Chemistry 2010, 75, 7519–7534: PMCID: PMC3038189 "Mechanism of the Cobalt Oxazoline Palladacycle (COP)-Catalyzed Asymmetric Synthesis of Allylic Esters" J. S. Cannon, S. F. Kirsch, L. E. Overman and H. F. Sneddon Journal of the American Chemical Society 2010, 132, 15192–15203: PMCID: PMC 2967776 "Catalytic Asymmetric Synthesis of Chiral Allylic Esters" J. S. Cannon, S. F. Kirsch and L. E. Overman Journal of the American Chemical Society 2010, 132, 15185–15191: PMCID: PMC 2966826 "Terminating Catalytic Asymmetric Heck Cyclizations by Stereoselective Intramolecular Capture of h3-Allylpalladium Intermediates: Total Synthesis of (–)-Spirotryprostatin B and Three Stereoisomers" L. E. Overman and M. D. Rosen Tetrahedron 2010, 66, 6514–6525: PMCID: PMC 2921616 "Total Synthesis of (+)-Sieboldine A" S. M. Canham, D. J. France and L. E. Overman Journal of the American Chemical Society 2010, 132, 7876–7877: PMCID: PMC 2885033 "Enantioselective Synthesis of Angularly Substituted 1-Azabicyclic Ring Systems: Dynamic Kinetic Resolution Using Aza-Cope Rearrangements" T. Ito, L. E. Overman and J. Wang, Journal of the American Chemical Society 2010, 132, 3272–3273: PMCID: PMC2858009 "Golgi Modifying Properties of Macfarlandin E and the Synthesis and Evaluation of Its 2,7-Dioxabicyclo[3.2.1]octan-3-one Core" M. J. Schnermann, C. M. Beaudry, A. V. Egorova, R. S. Polishchuk, C. Suetterlin and L. E. Overman Proceedings of the National Academy of Science (USA), 2010, 107, 6158–6163: PMCID: PMC 2851978