郝健 - 上海大学

研究领域

氟化学（包括金属催化/促进的二氟甲基官能团化、氟烷基化与反应机理、二氟亚甲基在靶向药物中的应用等）、特种含氟功能材料（包括OLED发光材料、导电高分子材料、电磁损耗材料、超疏水涂料、高化学耐腐涂料、高效海洋防污涂料等）

近期论文

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含氟b-氨基酸及其衍生物的合成进展, 彭荣达，郝健, 有机化学，2005, 25, 485-495. Grignard Cyclization Reaction of Fluorinated N-Aryl I_midoyl Chlorides. A Novel and Facile Access to the 2-Fluoroalkyl Indoles, Ge, F.; Wang, Z.; Wan, W.; Hao, J.* Synlett, 2007, 447-450. https://www.thieme-connect.com/ejournals/abstract/synlett/doi/10.1055/s-2007-967950 One-pot synthesis of 2-trifluoromethyl and 2-difluoromethyl substituted benzo-1,3-diazoles, Ge,F.; Wang, Z.; Wan, W.; Lu, W.; Hao, J.* Tetrahedron Lett. 2007, 48, 3251-3254. http://dx.doi.org/10.1016/j.tetlet.2007.03.015 5,5,5-Trifluoro-N-(4-fluorophenyl)-4-hydroxypentana_mide, Wan, W.; Ma, G.; Yuan, Z.; Li, M.; Hao, J.* Acta Cryst. 2007, E63, o1685–o1686. Fluorinated N-[2-(haloalkyl)phenyl]i__midoyl chloride, a key intermediate for the synthesis of2-fluoroalkyl substituted indole derivatives via Grignard cyclization process, Wang, Z.; Ge, F.; Wan, W.; Jiang,H.; Hao, J.* J. Fluorine Chem. 2007, 128, 1143-1152. http://dx.doi.org/10.1016/j.jfluchem.2007.04.023 3-Chloro-1,1,1-trifluoro-3-(triphenylphosphoranylidene)propan-2-one, Wang, Z.; Jiang, H.; Wan, W.; Ge,F.; Hao, J.* Acta Cryst. 2007, E63, o3152. Recent Progress in One-pot Synthesis of Fluorinated Building Blocks, Ren, X.; Wan, W.; Jiang, H.; Hao, J.* Mini-Rev. in Org. Chem. 2007, 4, 330-337. http://www.bentham.org/mroc/contabs/mroc4-4.htm#6 One-pot Cyclization of 2-Aminophenethyl Alcohols: A Novel and Direct Approach to the Synthesis of N-Acyl Indolines, Wang, Z.; Wan, W.; Jiang, H.; Hao, J.* J. Org. Chem. 2007, 72, 9364-9367. http://pubs.acs.org/doi/abs/10.1021/jo701566v 14-Androsta-5,15-dien-3-ol-17-one, Zheng, C.; Yao, S.; Wan, W.; Hao, J.* Acta Cryst. 2007, E63, o2651. Fluoroalkyl Substituted (Z)-Dehydro α-Amino Ester as a Building Block for the Fluorine-containing Cyclopropyl α-Amino Esters and Dihydrooxazole, Wan, W.; Gao, Y.; Jiang, H.; Hao, J.* J. Fluorine Chem. 2008, 129, 510-514. http://dx.doi.org/10.1016/j.jfluchem.2008.03.008 Synthesis and _characterization of triphenylene derivatives containing two terminal functional grous atthe periphery, Wan, W.*; Wang, P.; Jiang, H.; Hao, J. Mol Cryst Liq Cryst. 2008, 482, 42-56. Synthesis and _characterisation of nematic liquid crystalscontaining a trans-decalin ring, Wan, W.* Yang, C.; Jiang, H.; Wang, J. Hao, J. Liq. Cryst. 2008, 35, 665-673. Ethyl 2-phenyl-5-trifluoromethyl-1,3-thiazole-4-carboxylate, Jiang, H.; Wan, W.; Shao, M.; Hao, J.* Acta Cryst. 2008, E64, o2004. Concise Synthesis of ω-Fluoroalkylated Ketoesters. A Building Block for the Synthesis of 6-, 7-, and8-Membered Fluoroalkyl Substituted 1,2-Diaza-3-One Heterocycles, Wan, W.; Hou, J.;Jiang, H.; Wang,Y.; Zhu, S.; Deng, H.; Hao, J.* Tetrahedron, 2009, 65, 4214-4219. http://dx.doi.org/10.1016/j.tet.2009.03.029 Recent Progress on the Synthesis of Trifluoromethylated Heterocyclic Compounds Based on ethyl 4,4,4-trifluoroacetoacetate and its Derivatives, Zhu, S.Z.; Song, L.P.; Jin, G.F; Dai, B.F.;Hao, J. Current Org. Chem. 2009, 13, 1015-1027. http://www.bentham.org/coc/contabs/coc13-10.htm Reductive Amination/Cyclization of ω-Trifluoromethyl Ketoesters. Synthesis of Trifluoromethylated δ-Amino Alcohols and Lactams, Wan, W.; Hou, J.; Jiang, H.; Yuan, Z.; Ma, G.; Zhao, G.; Hao, J.* Eur. J. Org. Chem. 2010, 9, 1778-1786. http://www3.interscience.wiley.com/journal/123278435/abstract p-TsOH Promoted Fischer Indole Synthesis of Multi-Substituted 2-Trifluoromethyl Indole Derivatives, Jiang, H.; Wang, Y.; Wan, W.; Hao, J.* Tetrahedron, 2010, 66, 2746-2751. http://dx.doi.org/10.1016/j.tet.2010.01.080 Bromotriphenylphosphonium Salt Promoted Tandem One-Pot Cyclization to the Optically Active 2-Aryl-1,3-Oxazolines, Jiang, H.; Yuan, S.; Wan, W.; Yang, K.; Deng, H.; Hao, J.* Eur. J. Org. Chem. 2010, 9, 4227-4236. http://www3.interscience.wiley.com/journal/123525760/abstract C-9 Fluorenyl Substituted Anthracenes：A Promising New Family of Blue Luminescent Materials, Jing Wang, Wen Wan,* Haizhen Jiang, Yan Gao, Xueyin Jiang, Huaping Lin, Weiming Zhao and Jian Hao* Org. Lett. 2010, 12, 3874-3877. http://pubs.acs.org/doi/abs/10.1021/ol101553a A Facile One-pot Synthesis of 2-Fluoroalkyl 1,3-I_midazolines and 1,3-Oxazolines through I__midoyl Halide Intermediates, Haizhen Jiang*, Shijie Yuan, Yeshan Cai, Wen Wan, Shizheng Zhu and Jian Hao*, Tetrahedron, 2012, 68, 2858-2863. http://dx.doi.org/10.1016/j.tet.2012.01.086