Das, Chittaranjan - Purdue University - Department of Chemistry

个人简介

Ph.D. Indian Institute of Science (2001); Postdoctoral fellow (2001-2006) Harvard Medical School and Brandeis University.

近期论文

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Shrestha RK, Ronau JA, Davies CW, Guenette R, Strieter E, Paul LN and Das C* Insights into the mechanism of deubiquitination by JAMM deubiquitinases from co-crystal structures of enzyme with substrate and product Biochemistry 2014 (in press) Hussain S, Feldman A, Das C, Ziesmer S, Stephen Ansell and Galardy PJ* The ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4 mediated ubiquitination of raptor. Molecular Cell Biology 2013 33 1188-1197 DeWalt EL, Begue VJ, Ronau JA, Sullivan SZ, Das C, Simpson GJ* Polarization-resolved second harmonic generation microscopy as a method to visualize protein crystal domains Acta Crystallographica D 2013 D69 74-81 Davies CW, Paul LN and Das C* Mechanism of recruitment and activation of the endosome-associated deubiquitinase AMSH Biochemistry 2013 52 7818-7829 Morrow M, Kim M, Ronau JA, Chaney J, Rhiannon, W, Sheedlo M, Paul LN, Lill M, Artavanis-Tsakonas K, and Das C* Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity Biochemistry 2013 52 3564-3578 Arnst JL, Davies CW, Raja, SM, Das C, and Natarajan A* High-throughput compatible FRET-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity. Analytical Biochemistry 2013 440 71-77 Madden JT, Toth SJ, Dettmar C, Newman J, Oglesbee, R, Hedderich H, Everly M, Becker M, Ronau JA, Buchanan SK, Cherezov V, Morrow M, Shenglan X, Ferguson D, Makarov, Das C, Fischetti RF and Simpson. GJ* Integrated SONICC Microscope for On-axis Crystal Detection and Centering at a Synchrotron Beamline. Journal of Synchrotron Radiation 2013 20 531-540 Ronau JA, Paul LN, Fuchs, JE, Corn I, Wagner K, Liedl, KR, Abu-Omar M and Das C* An additional substrate binding site in a bacterial phenylalanine hydroxylase European Journal of Biophysics 2013 42 691-708 Davies CW and Das C* HHARI is One HECT of a RING. Structure 2013 21 872-874 Tsou W, Sheedlo MJ, Morrow ME, Blount J, McGregor KM, Das C, Todi SV* Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes. PloS ONE 2012 7 43112 Todi SV*, Das C Should Deubiquitinating Enzymes be Targeted for Therapy? Editorial in: Clinical Pharmacology & Biopharmaceutics 2012 1 1-3 Davies CW, Chaney J, Korbel, G, Ringe, D, Ploegh, H, Petsko GA and Das C* The co-crystal Structure of Ubiquitin Carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK) Bioorganic and Medicinal Chemistry Letters 2012 22 3900-3904 Boudreaux D, Chaney J, Maiti T and Das C* Contribution of active-site glutamine to rate enhancement in ubiquitin carboxy terminal hydrolases FEBS Journal 2012 279 1106-1118 Maiti, T. K.;Permaul, M.;Boudreaux, D. A.;Mahanic, C.;Mauney, S.;Das, C. Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme Febs Journal 2011 278 24 4917-4926 Davies CW, Paul LN, Kim M and Das C* Structural and Thermodynamic Comparison of the Catalytic Domain of AMSH and AMSH-LP: Nearly Identical Fold but Different Stability Journal of Molecular Biology 2011 413 416-29 Andersson FI, McMorran L, Werrell EF, Crone WJ, Das C, Hsu SD and Jackson SE The Effect of Parkinson’s Disease Associated Mutations on the Stability, Structure and Dynamics of the Deubiquitinating Enzyme UCH-L1 Journal of Molecular Biology 2011 407 261-271 Boudreaux, D. A.;Maiti, T. K.;Davies, C. W.;Das, C. Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation Proceedings of the National Academy of Sciences of 2010 107 20 9117-9122 Das, C.; Hoang, Q.Q.; Kreinbring, C.A.; Luchansky, S.J.; Meray, R.K. Ray, S.S.; Lansbury, P.T. Ringe, D.; Petsko, G.A. Structural basis of conformational plasticity of the Parkinson’s disease- associated ubiquitin hydrolase UCH-L1 Proceedings of the National Academy of Sciences USA 2006 103 - 4675-4680 Kornilova A.Y.; Bihel, F.; Das, C.; Wolfe, M.S. The initial substrate-binding site of gamma-secretase is located on presenilin near the active site Proceedings of the National Academy of Sciences USA 2005 102 - 3230-3235. Bihel F, Das C, Bowman MJ, Wolfe MS. Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 47 - 3931-3933