研究领域
不对称催化及生物正交化学
主要从事不对称催化和生物正交化学反应研究。
近期论文
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Nan Li, Carlo P. Ramil, Reyna K. V. Lim, and Qing Lin*, A Genetically Encoded Alkyne Directs Palladium-Mediated Protein Labeling on Live Mammalian Cell Surface. ACS Chem. Biol., 2014, In Press.
Nan Li, Reyna K. V. Lim, Selvakumar Edwardraja, Qing Lin*, Copper-Free Sonogashira Cross-Coupling for Functionalization of Alkyne-Encoded Proteins in Aqueous Medium and in Bacterial Cells. J. Am. Chem. Soc., 2011. 133. 15316-15319 (Highlighted in ChemBioChem. 2012, 13, 1728-1731).
Nan Li, Xiao-Hua Chen, Shi-Ming Zhou, Shi-Wei Luo, Jin Song, Lei Ren and Liu-Zhu Gong* Asymmetric Amplification in Phosphoric Acid Catalyzed Reactions. Angew Chem Int Ed., 2010, 49, 6378-6381. (Highlighted in Synfacts. 2010, 10, 1189-1189).
Nan Li, Jin Song, Xi-Feng Tu, Bin Liu, Xiao-Hua Chen and Liu-Zhu Gong*, Organocatalytic Asymmetric Intramolecular [3+2] Cycloaddition: A Straightforward Approach to Access Multiply Substituted Hexahydrochromeno[4,3-b]pyrrolidine Derivatives in High Optical Purity. Org. Biomol. Chem., 2010, 8, 2016-2019.
Nan Li, Xiao-Hua Chen, Jin Song, Shi-Wei Luo*, Wu Fan and Liu-Zhu Gong*, Highly Enantioselective Organocatalytic Biginelli and Biginelli-Like Condensations: Reversal of the Stereochemistry by Tuning the 3,3′-Disubstituents of Phosphoric Acids. J. Am. Chem. Soc., 2009. 131. 15301-15310.
Reyna K.V. Lim, Nan Li, Carlo P. Ramil and Qing Lin*, Fast and sequence-specific palladium-mediated cross-couping reaction identified from phage display. ACS Chem. Biol., 2014, 9, 2139-2148.
Gang Cheng, Reyna K. V. Lim, Nan Li, Qing Lin*, Storable Palladacycles for Selective Functionalization of Alkyne-Containing Proteins. Chem. Commun., 2013. 49. 6809-6811.
Avinash Muppidi, Hongtao Zhang, Francesca Curreli, Nan Li, Asim K. Debnath and Qing Lin*, Design of antiviral stapled peptides containing a biphenyl cross-linker. Bioorg. Med. Chem. Lett., 2014, 24, 1748-1751.