陈建新 - 山西师范大学 - 有机化学研究所

研究领域

1.有机硅化学方面：合成新的有机硅化合物—氨甲酰基硅烷. 氨甲酰基硅烷就是利用硅基团活化了酰基碳原子，使其具有与一般羰基化合物相反的性能即亲核性能，因而可作为一种以亲核性特征带入酰基的试剂，与一些亲电中心发生反应，使分子结构中带入酰基片段，实现某些化合物的合成, 建立新的合成路线. 它与碳-氮双键加成可生成氨基酸衍生物; 与醛酮反应可生成羟基酰胺; 与酰卤反应可生成羰基酰胺; 与卤代烃反应可发生交叉偶联, 把氨酰基代入分子. 2.仿生有机合成方面：模拟四氢叶酸辅酶结构与功能合成模型化合物，实现取代一碳单元的转移反应。合成出四氢叶酸辅酶各种模型化合物，实现两个碳单元以及多个碳单元的半转移反应和全转移反应, 建立新的仿生合成路线. 3.新药的合成及生理活性研究：哌嗪类化合物在临床上已有应用，并且结构不同，具有多种治疗作用，我们合成各种结构新的哌嗪化合物，并确定其结构，通过生物活性实验发现活性较高的结构，然后做进一步的筛选和药学分析。

近期论文

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Guo W. Y. and Chen J. X.* “Novel method for stereoselective synthesis of α-aminoamide compounds”, Chin. Chem. Bull., 2013, 76 (9), 843-848. Ma F. and Chen J. X.* “Novel method for synthesis of unsymmetrical –organyl-α-hydroxymalonamide derivatives”, Acta Chim. Sinica, 2013, 71(8), 1118-1120. Guo W. Y., Yao Y., Chen X. J. and Chen J. X.* “Asymmetric synthesis of α-aminoamides derivatives”, Chinese. J. Medici. Chem., 2013, 23(3), 197-202. Chen X. J. and Chen J. X.* “Synthesis of 2-hydroxymalonamides from carbamoylsilane and α-ketocarboxamides”, Mendeleev Commun., 2013, 23(2), 106-107. Zhao Y. Q. and Chen J. X.* “Groups transfer reaction of imidazolinium salts as tetrahydrofolate model compounds”, Chem. J. Chinese Universities, 2012, 33(12), 2670-2675. Chen J. X.*and Wen X. S. “Reaction of carbamoylsilane with nitrone and tautomerism of product”, Acta Chimica Sinica, 2009, 64(14), 1709-1711. Cunico R. F. *, Pandey R. K., Chen J. X. and Motta A. R. “Copper(II) trifluor methanesalfonate catalyzed addition of a carbamoylsilane to aldehyde imines”, SynLett , 2005, 20, 3157-3159. Chen J. X. and Cunico R. F.* “Diastereoselectivity of α-aminoamides from carbamoylsilanes and aldehydeimines”, Tetrahedron Asymmetry, 2005, 16(5), 941-947. Chen J. X. and Cunico R. F. “Synthesis of α-ketoamides from a carbamoylsilane and an acid chloride”, J.Org.Chem. 2004, 69(16), 5509-5511. Chen J. X. and Cunico R. F.* “α-Aminoamides from a carbamoylsilane and aldehydeimines”, Tetrahedron Lett., 2003, 44(43), 8025-8027. Cunico R. F.* and Chen J. X. “On the preparation of carbamoylsilanes”, Synth. Commun. 2003, 33(11), 1963-1968. Chen J. X. and Cunico R. F.* “α-(Dimethylamino) amides from a carbamoylsilane and iminium salts”, Tetrahedron Lett., 2002, 43(47), 8595-8597. Xia C. Z., Chen J. X., Zhao B. J., Wang H. X., Kang C. M. and Zhou P. W.* “Aminolysis of 1,2-dimethyl-3-arylsulfonyl-4,5-dihydroimidazolium iodides with aromatic amines”, Synth. Commun. 2002, 32 (7), 1129-1134. Xia C. Z., Wang H. X., Zhao B. J., Kang C. M., Chen J. X. and Zhou P. W.* “A convenient synthesis of imidazolium salts and trisubstituted ethylenediamine derivatives”, Synth. Commun. 2002, 32 (9), 1447-1455. Chen J. X.* and Xia C. Z. “Synthesis of β-carboline alkaloids with the tetrahydrofolic model compound”, Chinese. J. Medici. Chem., 2001, 11(4), 230-232. Xia C. Z., Kang C. M., Zhao B. J., Chen J. X., Wang H. X. and Zhou P. W.* “A convenient synthesis of N, N, N'-trisubstituted ethylenediamine derivatives from 2-methyl-2– imidazoline”, Synth. Commun. 2000, 30(18), 3307-3315. Zhou P. W., Zhao B. J., Chen J. X., Wang H. X., Kang C. M. and Xia C. Z.* “Reactions of 1,2-dimethyl-3-arylsulfonyl-4,5-dihydroimidazolium iodides with bifunctional nucleophiles”, Heterocycles, 2000, 53(2), 433-439. Chen J. X.*, Hao J. S., Guo W. and Xia C. Z. “Rearrangement of hydrolysis products of tetrahydrofolate model compound”,Chinese Chem. Lett. 1999, 10(9), 727-728. Du H. W., Chen J. X., Hao J. S, Pan J. G. and Xia C. Z.* “Stereoselective synthesis of L-threo-dihydrophingosines”, Chem. J. Chinese Universities, 1999, 20(4), 590-592. Chen J. X.*, Pan J. G., Xia C. Z. and Cheng J. P. “Mimicking of structure and properties of tetrahydrofolic coenzyme and study on their substituted one-carbon unit transfer reactions”, Acta Chim. Sinica, 1998, 56(8), 819-826.