个人简介

Biosketch: Vy Dong was born in Big Spring, Texas and spent early childhood in west Texas before moving with family to Anaheim, California. She graduated magna cum laude from UC Irvine where she majored in chemistry and completed an honor's project with Larry Overman. After graduation, she joined David MacMillan's group at UC Berkeley, and then moved with his group to Caltech to complete her doctoral studies. Her Ph.D. thesis featured variants of the zwitterionic-Claisen rearrangement and a total synthesis of erythronolide B. As an NIH postdoctoral fellow, Vy pursued training in organometallic and supramolecular chemistry with Robert Bergman and Kenneth Raymond at Berkeley. She began her independent academic career at the University of Toronto, where she was promoted with tenure and named the Adrian Brook Professor. After six years in Canada, Vy returned to the United States to assume a professorship at her alma mater, UC Irvine. Professor Dong's research team is interested in new reaction methods, enantioselective catalysis, and natural product synthesis. Honors and Awards: The Society of Synthetic Organic Chemistry, Japan, 2013 Lectureship Japan Society for the Promotion of Science Fellowship (2013) Novartis Chemistry Lecturer (2012-2013) Eli Lilly Grantee Award (2011-2012) Roche Excellence Award in Chemistry (2011) ACS Arthur C. Cope Scholar Award (2010) Adrian Brook Distinguished Professor (2011) Early Researcher Award (2010) Amgen Young Investigator (2010) AstraZeneca Award in Chemistry (2010-2012) Alfred P. Sloan Research Fellowship (2009-2011) Inaugural Eli Lilly Young Investigator Lecturer at the University of Wisconsin-Madison (2009) CNC-IUPAC Travel Award (2009) Boehringer Ingelheim (Canada) Young Investigator Award for Organic Chemistry (2008-2011) Ontario Research Fund (2008-2011) Connaught New Staff Matching Grant (2007) Merck Frosst Young Investigator Award (2007) Thieme Synlett/Synthesis Journal Award (2007) Ruth L. Kirschstein National Institutes of Health Postdoctoral Fellowship (2004-06) National Science Foundation Graduate Research Fellowship (1999-2003) Anna Louise Hoffman Award for Graduate Research from Iota Sigma Pi (2002) American Chemical Society Poster Award Winner, Pacifichem ACS Conference (2000) Don L. Bunker Honor’s Thesis Prize, UC Irvine, (1998) Chancellor’s Award for Excellence in Undergraduate Research, UC Irvine (1998) Phi Beta Kappa (1998) Pfizer Organic Chemistry Fellowship (1997) Brookhaven National Lab Nuclear and Radiochemistry Fellowship (1997) Scientific and Editorial Advisory Boards: Associate Editor for Chemical Science (2015-present) Corvinus Chemicals (2014-present) Cambridge Major Laboratories (2014) Organometallics Advisory Board (2013-2015) Beilstein Journal of Organic Chemistry Associate Editor (2012-2015) Journal of Organic Chemistry Editorial Advisory Board (2012-2016) Asian Journal of Organic Chemistry International Advisory Board (2012 to 2016) Organic Letters Editorial Advisory Board (2011-2014) Advanced Synthesis and Catalysis Academic Advisory Board (2011-2016)

研究领域

Organic and Synthetic Chemistry

New reaction methods, enantioselective catalysis, and natural product synthesis.

近期论文

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Chen, Q. A.; Cruz, F. A.; Dong, V. M. "Alkyne Hydroacylation: Switching Regioselectivity by Tandem Ruthenium Catalysis." J. Am. Chem. Soc. ASAP. Murphy, S. K.; Park, J.-W.; Cruz, F. A.; Dong, V. M. "Rh-catalyzed C-C bond cleavage by transfer hydroformylation." Science 2015, 2, 56. Thanks to Clark Landis for the perspective in Science. Read the highlight from C&E News. Read the highlight in Korean from Dong-A Science. Whittaker, A. M.; Dong, V. M. "Ni-Catalyzed Dehydrogenative Cross-Coupling: Direct Transformation of Aldehydes to Esters and Amides." Angew. Chem. Int. Ed. 2015, 54, 1312. Murphy, S. K.; Bruch, A.; Dong, V. M. "Mechanistic Insights into Hydroacylation with Non-chelating Aldehydes and 2-Vinylphenols." Chem. Sci. 2015, 6, 174. Edge Article. Oldenhuis, N. J.; Dong, V. M.; Guan, Z. "From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination." J. Am. Chem. Soc. 2014, 136, 12548. Kou, K. G. M.; Le, D. N.; Dong, V. M. "Rh(I)-Catalyzed Intermolecular Hydroacylation: Enantioselective Cross-Coupling of Aldehydes and Ketoamides." J. Am. Chem. Soc. 2014, 136, 9471. Chen, I.-H.; Kou, K. G. M.; Le, D. N.; Rathbun C. M.; Dong, V. M. "Recognition and Site-Selective Transformation of Monosaccharides Using Copper(II) Catalysis." Chem. Eur. J. 2014, 20, 5013. Read the highlight from SYNFACTS. Chen, Q. A.; Kim, D. K.; Dong, V. M. "Regioselective Hydroacylation of 1,3-Dienes by Cobalt-Catalysis." J. Am. Chem. Soc. 2014, 136, 3772. Murphy, S. K.; Bruch, A.; Dong, V. M. "Substrate-Directed Hydroacylation: Rh-Catalyzed Coupling of Vinyl Phenols and Non-Chelating Aldehydes." Angew. Chem. Int. Ed. 2014, 53, 2455. Dornan, P. K.; Kou, K. G. M.; Houk K. N.; Dong, V. M. "Dynamic Kinetic Resolution of Allylic Sulfoxides by Rh-Catalyzed Hydrogenation: A Combined Theoretical and Experimental Mechanistic Study." J. Am. Chem. Soc. 2014, 136, 291. Murphy, S. K.; Dong, V. M. "Enantioselective Ketone Hydroacylation using Noyori's Transfer Hydrogenation Catalyst." J. Am. Chem. Soc. 2013, 135, 5553. von Delius, M.; Le, C. M.; Dong, V. M. "Rhodium-Phosphoramidite Catalyzed Alkene Hydroacylation: Mechanism and Octaketide Natural Product Synthesis." J. Am. Chem. Soc. 2012, 134, 15022. Murphy, S. K.; Coulter, M. M.; Dong, V. M. "β-Hydroxy Ketones Prepared by Regioselective Hydroacylation." Chem. Sci. 2012, 3, 355. Murphy, S. K.; Petrone, D. A.; Coulter, M. M.; Dong, V. M. "Catalytic Hydroacylation as an Approach to Homoaldol Products." Org. Lett. 2011, 13, 6216. Yeung, C. S.; Hsieh, T. H. H.; Dong, V. M. "Ru-catalyzed Activation of sp3 C–O Bonds: O- to N-Alkyl Migratory Rearrangement in Pyridines and Related Heterocycles." Chem. Sci. 2011, 2, 544. Top ten most accessed articles in December 2010. Khan, H. A.; Kou, K. G. M.; Dong, V. M. "Nitrogen-directed Ketone Hydroacylation: Enantioselective Synthesis of Benzoxazepinones and Benzoxazecinones." Chem. Sci. 2011, 2, 407. Featured on the cover with artwork by Peter Dornan. Top ten most accessed articles in December 2010. Zhao, X.; Dong, V. M. "Carbon-Sulfur Reductive Elimination from Pd(IV) Sulfinate Complexes." Angew. Chem. Int. Ed. 2011, 50, 932. Coulter, M. M.; Kou, K. G. M.; Galligan, B.; Dong, V. M. "Regio- and Enantioselective Intermolecular Hydroacylation: Substrate-Directed Addition of Salicylaldehydes to Homoallylic Sulfides." J. Am. Chem. Soc. 2010, 132, 16330. Phan, D. H. T.; Kou, K. G. M.; Dong, V. M. "Enantioselective Desymmetrization of Cyclopropenes by Hydroacylation." J. Am. Chem. Soc. 2010, 132, 16354. Coulter, M. M.; Dinglasan, J.; Goh, J. B.; Nair, S.; Anderson, D. J.; Dong, V. M. "Preparing Water-Dispersed Palladium Nanoparticles via Polyelectrolyte Nanoreactors." Chem. Sci. 2010, 1, 772. Read the highlight from Chemical Science Blog. Yeung, C. S.; Zhao, X.; Borduas, N.; Dong, V. M. "Pd-Catalyzed ortho-Arylation of phenylacetamides, benzamides, and anilides with simple arenes using sodium persulfate." Chem. Sci. 2010, 1, 331. Top ten most accessed articles in August 2010. Zhao, X.; Yeung, C. S.; Dong, V. M. "Palladium-Catalyzed Ortho-Arylation of O-Phenylcarbamates with Simple Arenes and Sodium Persulfate." J. Am. Chem. Soc. 2010, 132, 5837. Li, Y.; Jardine, K. J.; Tan, R.; Song, D.; Dong, V. M. "Palladium-Catalyzed Intramolecular Carboesterification of Olefins: A Formal [3+2] Cycloaddition." Angew. Chem. Int. Ed. 2009, 48, 9690. Selected by the editors as a "Hot Paper". Phan, D. H. T.; Kim, B.; Dong, V. M. "Phthalides by Rhodium-Catalyzed Ketone Hydroacylation." J. Am. Chem. Soc. 2009, 131, 15608. Read the highlight from SYNFACTS. Read the highlight in Angewandte by Michael Willis. Coulter, M. M.; Dornan, P. K.; Dong, V. M. "Rh-Catalyzed Intramolecular Olefin Hydroacylation: Enantioselective Synthesis of Seven- and Eight-Membered Heterocycles." J. Am. Chem. Soc. 2009, 131, 6932. Read the highlight from SYNFACTS. Zhao, X.; Dimitrijević, E.; Dong, V. M. "Palladium-Catalyzed C–H Bond Functionalization with Arylsulfonyl Chlorides." J. Am. Chem. Soc. 2009, 131, 3466. Shen, Z.; Dornan, P. K.; Khan, H. A.; Woo, T. K.; Dong, V. M. "Mechanistic Insights into the Rhodium-Catalyzed Intramolecular Ketone Hydroacylation." J. Am. Chem. Soc. 2009, 131, 1077. Shen, Z.; Dong, V. M. "Benzofurans Prepared by C-H Bond Functionalization with Acylsilanes." Angew. Chem. Int. Ed. 2009, 48, 784. Read the highlight from SYNFACTS. Yeung, C. S.; Dong, V. M. "Beyond Aresta’s Complex: Ni- and Pd-Catalyzed Organozinc Coupling to CO2." J. Am. Chem. Soc. 2008, 130, 7826. Read the highlight from SYNFACTS. Read the highlight in Angewandte by Martin and Correa. Li, Y.; Song, D.; Dong, V. M. "Palladium-Catalyzed Olefin Dioxygenation." J. Am. Chem. Soc. 2008, 130, 2962. Read the highlight from SYNFACTS. Shen, Z.; Khan, H. A.; Dong, V. M. "Rh-Catalyzed Carbonyl Hydroacylation: An Enantioselective Approach to Lactones." J. Am. Chem. Soc. 2008, 130, 2916. See the highlight in Chemistry World featuring this work: James Mitchell Crow, "Rhodium fast tracks route to lactones." Oldenhuis, N. J.; Dong, V. M.; Guan, Z. "Catalytic acceptorless dehydrogenations: Ru-Macho catalyzed construction of amides and imines." Tetrahedron 2014, 70, 4213. [Sarah Reisman] Invited contribution in honor of Sarah Reisman. Phan, D. H. T.; Dong, V. M. "Silver-catalyzed ring-opening of cyclopropenes: preparation of tertiary α-branched allylic amines." Tetrahedron 2013, 69, 5726. [Melanie Sanford] Invited contribution in honor of Melanie Sanford. Dornan, P. K.; Leung, P. L.; Dong, V. M. "Synthesis of C3- and C2-symmetric tris- and bis-sulfoxide ligands by asymmetric oxidation." Tetrahedron 2011, 67, 4378. [Dean Toste] Invited contribution in honor of Dean Toste. Borduas, N.; Lough, A. J.; Dong, V. M. "Cyclopalladation of N-Phenylbenzamides: Synthesis and Structure of Bimetallic Palladium(II)-Complexes." Inorg. Chem. Acta. 2011, 369, 247. [Robert Bergman] Invited contribution in honor of Robert Bergman. Yeung, C. S.; Dong, V. M. "Pd-catalyzed ortho-Arylation of N-Aryloxazolidinones with Simple Arenes Using Sodium Persulfate." Synlett. 2011, 7, 974. [Xiyan Lu] Invited contribution in honor of Xiyan Lu and Li-Xin Dai. Hsieh, T. H. H.; Dong, V. M. "Indole Synthesis: Palladium-Catalyzed C–H Bond Amination via Reduction of Nitroalkenes with Carbon Monoxide." Tetrahedron 2009, 65, 3062. [Justin Du Bois] Invited contribution in honor of Justin Du Bois's Young Investigator Award. Highlights and Reviews Murphy, S. K.; Dong, V. M. "Catalytic Enantioselective hydroacylation of olefins with rhodium catalysts." Chem. Commun. 2014, 50, 13645. Yeung, C. S.; Dong, V. M. "Catalytic Making C-C Bonds from Carbon Dioxide via Transition-Metal Catalysis." Topics in Catalysis. 2014, 57, 1342. Coulter, M. M.; Dong, V. M. "Transition Enantioselective Synthesis of Lactones via Rh-Catalyzed Ketone Hydroacylation" in Asymmetric Synthesis II: More Methods and Applications, M. Christmann; S. Brase; Wiley-VCH: New York, 2012; Chapter 35. Gladysz, J.; Ball, Z. T.; Bertrand, G.; Blum, S. A.; Dong, V. M.; Dorta, R.; Hahn, F. E.; Humphrey, M. G.; Jones, W. D.; Klosin, J.; Manners, I.; Marks, T. J.; Mayer, J. M.; Rieger, B.; Ritter, J. C.; Sattelberger, A. P.; Schomaker, J. M.; Yam V. W. "Organometallics Roundtable 2011." Organometallics 2012, 31, 1. Yeung, C. S.; Dong, V. M. "Catalytic Dehydrogenative Cross-Coupling: Forming Carbon-Carbon Bonds by Oxidizing Two Carbon-Hydrogen Bonds." Chem. Rev. 2011, 111, 1215. Yeung, C. S.; Dong, V. M. "New Direction in Enantioselective Catalysis: Scaffolding Ligands in Olefin Hydroformylation", Highlight article, Angew. Chem. Int. Ed. 2011, 50, 809. Yeung, C. S.; Dornan, P. K.; Dong, V. M. "Transition Metal Catalyzed Approaches to Lactones Involving C-O Bond Formation" in Catalyzed Carbon-Heteroatom Bond Formation, A. K. Yudin; Wiley-VCH: New York, 2010; Chapter 2.