Cooks, R. Graham - Purdue University - Department of Chemistry

个人简介

B.Sc. University of Natal, South Africa 1961 M.S. University of Natal, South Africa 1963 Ph.D. University of Natal, South Africa (Frank L. Warren, advisor) 1965 Ph.D. Cambridge University, Great Britain (Peter Sykes, advisor) 1967 Professional Experience and Visiting Positions Post-doctoral Fellow, Cambridge University (Dudley H. Williams, advisor) 1967-1968 Assistant Professor, Chemistry Dept., Kansas State Univ. 1968-1971 Co-Director of Mass Spectrometry Center, Purdue Univ. 1971-1973 Director of Mass Spectrometry Center, Purdue University 1973-1986 Associate Professor of Chemistry, Purdue University 1975-1979 Professor of Chemistry, Purdue University 1980-present Fulbright Senior Fellow, University of Warwick 1981 Adjunct Professor, Beijing Institute of Technology 1987-present Head, Analytical Division, Purdue University 1989-1996, 2006-2009 Adjunct Professor, Beijing Institute of Technology 1987-2000 Henry Bohn Hass Distinguished Professor of Chemistry, Purdue University 1990-present Guest Professor, Jilin University, Changchun, China, 2002–2003 Honorary Professor, Jilin University, 2003-2007 Guest Professor, Chemistry Dept., Tsinghua University, Beijing, China, 2004-2007 Co-Director, Center for Analytical Instrumentation Development, Purdue University, 2008-present Distinguished Professor, Indian Institute of Technology Madras, Chennai, India, 2013-present Honorary Professor, East China Institute of Techonology, Nanchang, China, 2016-present Guest Professor, Nanjing, China, 2018-present

研究领域

Accelerated Reactions in Confined Volumes The rate of many reactions can be dramatically increased in microdroplets and thin films compared with bulk phase. This is thought to occur through increased reagent concentration due to desolvation, pH extrema, Le Chatilier's principle, as well as decreased reaction activation energy at the partially desolvated droplet/thin film surface. Brain Cancer Diagnostics Molecular measurements by mass spectrometry in the surgical suite allow for rapid identification of tissue types, estimation of tumor infiltration, and recognition of the presence of prognostic mutations by monitoring of oncometabolites and phospholipids. MRM-Profiling for Lipidomics and Metabolomics Multiple reaction monitoring (MRM)-profiling searches for metabolites with precursor and neutral loss scans in a representative sample and uses these transitions to discriminate samples between healthy and diseased. High Throughput Synthesis and Analysis High-throughput mixture anaylsis arrays using desorption eelectrospray ionziation allow for on-line process rate that approach 104 reactions per hour. Data are analyzed automatically by MS using in-house software to produce intensity plots in standard array format. Ion Trap Developments Novel ion trap scanning methodologies to allow for data-independent analysis of complex mixtures in a single linear quadrupole ion trap mass analyzer with applications in miniature mass spectrometry. Ambient Pressure Ion Manipulation and Ion Mobility Spectrometry Rapid prototyping methods are used to fabricate lens systems and produce devices for ion focusing, separation, and detection at ambient pressure. Forensic and Public Safety Applications of Ambient Ionization Application of ambient ionzation and mass spectrometry to current problems in analytical chemistry, including detection of drugs, explosives, and chemcial warfare agents. Mass Spectrometry in the Undergraduate Laboratory Development of novel, mass-spectrometry based laboratory excercises for undergraduate students.

近期论文

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Kai-Hung Huang, Zhenwei Wei, and R. Graham Cooks “Accelerated Reactions of Amines with Carbon Dioxide Driven by Superacid at the Microdroplet Interface” Chem. Sci. (2020) DOI: 10.1039/D0SC05625A Rong Chen, Zhenwei Wei, and R. Graham Cooks “Collection and Characterization by Mass Spectrometry of the Neutral Serine Octamer Generated upon Sublimation” Anal. Chem. (2020) DOI: 10.1021/acs.analchem.0c04107 H. Samuel Ewan, Shruti A. Biyana, Jaycie DiDomenico, David Logsdon, Tiago J.P. Sobreira, Larisa Avramova, and R. Graham Cooks “Aldol Reactions of Biorenewable Triacetic Acid Lactone Precursor Evaluated Using Desorption Electrospray Ionization Mass Spectrometry High-Throughput Experimentation and Validated by Continuous Flow Synthesis” ACS Comb. Sci. (2020) DOI: 10.1021/acscombsci.0c00119 Madison E. Edwards, Thomas De Luca, Christina Ferreira, Kimberly S. Collins, Eric A. Benson, Tiago J.P. Sobreira, and R. Graham Cooks “Multiple reaction monitoring profiling as an analytical strategy to investigate lipids in extracellular vesicles” J. Mass. Spectrom. (2020) DOI: 10.1002/jms.4681 Yangjie Li, Tsdale Mehari, Zhenwei Wei, Yong Liu, and R. Graham Cooks “Reaction Acceleration at Solid/Solution Interfaces: Katritzky Reaction Catalyzed by Glass Particles” Angew. Chem. Int. Ed. (2020) DOI: 10.1002/anie.202014613 David L. Logsdon, Yangjie Li, Tiago J. P. Sobreira, Christina R. Ferreira, David H. Thompson, and R. Graham Cooks “High Throughput Screening of Reductive Amination Reactions using Desorption Electrospray Ionization (DESI) Mass Spectrometry” Org. Process Res. Dev. (2020) DOI: 10.1021/acs.oprd.0c00230 Nicolás M. Morato, Dylan T. Holden, and R. Graham Cooks “High Throughput Label-Free Enzymatic Assays using Desportion Electrospray Ionization Mass Spectrometry” Angew. Chem. Int. Ed. (2020) DOI: 10.1002/anie.202009598 Pallab Basuri, L. Edwin Gonzalez, Nicolas M. Morato, Thalappil Pradeep, and R. Graham Cooks “Accelerated Microdoplet Synthesis of Benzimidazoles by Nucleopilic Addition to Protonated Carboxylic Acids” Chem. Sci. (2020) DOI: 10.1039/D0SC02467H Robert L. Schrader, Brett M. Marsh, and R. Graham Cooks “Temporal distribution of ions in ambient pressure drift tubes with turns” IJMS (2020) DOI: 10.1016/j.ijms.2020.116391 Yangjie Li, Yanyang Hu, David L. Logsdon, Yong Liu, Yuejie Zhao, and R. Graham Cooks “Accelerated Forced Degradation of Theraputic Peptides in Levitated Micrdoplets” Pharmaceutical Research (2020) DOI: 10.1007/s11095-020-02868-y Tiago J. P. Sobreira, Larisa Avramova, Botond Szilagyi, David L. Logsdon, Bradley P. Loren, Zinia Jaman, Ryan T. Hilger, Richard S. Hosler, Christiana R. Ferreira, Andy Koswara, David H. Thompson, R. Graham Cooks, and Zoltan K. Nagy “High-throughput screening of organic reactions in microdroplets using desorption electrospray ionzation mass spectrometry (DESI-MS): hardware and software implementation” Anal. Meth. (2020) DOI: 10.1039/D0AY00072H Lucas J. Szalwinski, Dylan T. Holden, Nicolás M. Morato, and R. Graham Cooks “2D MS/MS Spectra Recorded in the Time Domain using Repettitive Frequency Sweeps in Linear Quadrupole Ion Traps” Anal. Chem (2020) DOI: 10.1021/acs.analchem.0c01719 Yangjie Li, Tsdale F. Mehari, Zhenwei Wei, Yong Liu, and R. Graham Cooks “Reaction Acceleration at Air-Solution Interfaces: Anisotropic Rate Constants for Katritzky Transamination” J. Mass. Spectrom. (2020) DOI: 10.1002/jms.4585 Namita Narendra, Xingshuo Chen, Jinyin Wang, James Charles, R. Graham Cooks, and Tillmann Kubis “Quantum Mechanical Modeling of Reaction Rate Acceleration in Microdroplets” J. Phys. Chem. A (2020) DOI: 10.1021/acs.jpca.0c032254 Zhenwei Wei, Yangjie Li, R. Graham Cooks, and Xin Yan “Accelerated Reaction Kinetics in Microdroplets: Overview and Recent Developments” Ann. Rev. Phys. Chem. (2020) DOI: 10.1146/annurev-physchem-121319-110654 Lucas J. Szalwinski, Dalton T. Snyder, Mitch Wells, and R. Graham Cooks “Triple Resonance Methods to Improve Performance of Ion Trap Precursor and Neutral Loss Scans” J. Am. Soc. Mass Spectrom. (2020) DOI: 10.1021/jasms.0c00048 Nicolás M. Morato and R. Graham Cooks “Cutting-edge developments in mass spectrometry: A hands-on workshops” Int. J. Mass Spectrom. (2020) DOI: 10.1016/j.ijms.2020.116337 Patrick W. Fedick, Nicolás M. Morato, Fan Pu, and R. Graham Cooks “Raman spectroscopy coupled with ambient ionization mass spectrometry: A forensic laboratory investigation into rapid and simple dual instrumental analysis techniques” Int. J. Mass Spectrom. (2020) DOI: 10.1016/j.ijms.2020.116326 Zinia Jaman, David L. Logsdon, Botond Szilágyi, Tiago J. P. Sobreira, Deborah Aremu, Larisa Avramova, R. Graham Cooks, and David H. Thompson “High-Throughput Experimentation and Continuous Flow Evaluation of Nucleophilic Aromatic Substitution Reactions” ACS Comb. Sci. (2020) DOI: 10.1021/acscombsci.9b00212 Robert L. Schrader, Brett M. Marsh, and R. Graham Cooks “Fourier Transform Ion Mobility Linear Ion Trap Mass Spectrometer using Frequency Encoding for Recognition of Related Compounds in a Single Acquisition” Anal. Chem. (2020) DOI: 10.1021/acs.analchem.9b05507