个人简介
徐克花，女，教授，博士生导师。
1984年毕业于曲阜师范大学，分配到山东师范大学任教。1991年获山东医科大学理学硕士学位。2007年获山东师范大学博士学位。主要研究方向是荧光探针合成及细胞成分分析。已在 Chem. Sci., Anal. Chem., Chem. Eur. J, Chem. Commun., ChemBioChem., FEBS J.等重要刊物发表论文46篇, 均被SCI收录；2009－2010年在美国俄亥俄大学访问期间利用质谱研究巯基小肽及蛋白的标记工作，其研究成果发表在美国分析化学上。主持国家及省自然科学基金5项；参与国家重点项目、重大研究计划项目及973课题多项。是973课题主要骨干成员之一。相关研究获得2008年山东省自然科学一等奖（第三位），山东高等学校优秀科研成果二等奖（第一位）及2006年山东高等学校优秀科研成果一等奖(第二位)。2012年获山东高等学校优秀科研成果一等奖（第一位）。
近期论文
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Kehua Xu, Mingming Qiang, Wen Gao, Ruixian Su, Na Li, Yan Gao, Yanxia Xie, Fanpeng Kong and Bo Tang*, A near-infrared reversible fluorescent probe for real-time imaging of redox status changes in vivo,Chem. Sci., 4, 1079, 2013.
Kehua Xu, Feng Wang, Xiaohong Pan, Renpu Liu, Jing Ma, Fanpeng Kong and Bo Tang*, High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor,Chem. Commun., 49, 2554,2013.
Kehua Xu, Shuxia Sun, Jing Li, Lu Li, Mingming Qiang and Bo Tang, A near-infrared fluorescent probe for monitoring ozone and imaging in living cells,Chem. Commun.,48, 684–686, 2012.
Kehua Xu,Lulu Wang, Mingming Qiang, Liyong Wang, Ping Li, Bo Tang, A selective near-infrared fluorescent probe for singlet oxygen in living cells,Chem. Commun., 47, 7386–7388,2011.
Kehua Xu, Huachao Chen, Huixia Wang, Jiangwei Tian, Jing Li, Qingling Li, Na Li, Bo Tang, A nanoprobe for nonprotein thiols based on assembling of QDs and 4-amino-2,2,6,6- tetramethylpiperidine oxide,Biosensors and Bioelectronics,26, 4632– 4636,2011.
Kehua Xu,Fen Liu, Jing Ma, Bo Tang, A new specific fullerene-based fluorescent probe for trypsin,Analyst, 136, 1199,2011
Kehua Xu, Huachao Chen, Jiangwei Tian, Baiyu Ding, Yanxia Xie, Mingming Qiang, Bo Tang, A near-infrared reversible fluorescent probe for peroxynitrite and imaging of redox cycles in living cells,Chem. Commun., 47, 9468–9470,2011.
Wen Gao, Lifei Ji, Lu Li, Guanwei Cui,Kehua Xu, Ping Li, Bo Tang*, Bifunctional combined Au-Fe2O3 nanoparticles for induction of cancer cell-specific apoptosis and real-time imaging.Biomaterials, 33, 3720-3728,2012.
Wen Gao,Kehua Xu, Ping Li, Bo Tang*. Functional roles of superoxide and hydrogen peroxide generated by mitochondrial DNA mutation in regulating tumorigenicity of HepG2 cells.Cell Biochem Funct, 400–407,2011
Xinyuan Zhang, Qingling Li, Zhenzhen Chen, Hongmin Li,Kehua Xu, Lisheng Zhang and Bo Tang*. Electrokinetic gated injection-based microfluidic system for quantitative analysis of hydrogen peroxide in individual HepG2 cells.Lab Chip, 11, 1144-1150,2011.
Dongmei Chen, Zhenzhen Chen,Kehua Xu, and Bo Tang*. Studies on the Supramolecular Interaction between Dimethomorph and Disulfide Linked β-Cyclodextrin Dimer by Spectrofluorimetry and Its Analytical Application,J. Agric. Food Chem, 59, 4424–4428,2011.
Wen Gao,Kehua Xu, Lifei Ji,Bo Tang*.Effect of gold nanoparticles on glutathione depletion-induced hydrogen peroxide generation and apoptosis in HL7702 cells.Toxicology Letters, 205, 86-95,2011.
Kehua Xu, Yun Zhang, Bo Tang, Julia Laskin, Patrick J. Roach, Hao Chen, Study of Highly Selective and Efficient Thiol Derivatization Using Selenium Reagents by Mass Spectrometry,Anal. Chem.2010, 82, 6926–6932.
Zhenzhen Chen, Qingling Li, Xu Wang, Zhiyuan Wang, Ruirui Zhang, Miao Yin, Lingling Yin,Kehua Xu, and Bo Tang*, Potent Method for the Simultaneous Determination of Glutathione and Hydrogen Peroxide in Mitochondrial Compartments of Apoptotic Cells with Microchip Electrophoresis-Laser Induced Fluorescence.Anal.Chem. 82, 2006–2012,2010.
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